Results 71 to 80 of about 31,607 (207)

Gene diversity explains variation in biological features of insect killing fungus, Beauveria bassiana

Scientific Reports, 2021
Beauveria bassiana is a species complex whose isolates show considerable natural genetic variability. However, little is known about how this genetic diversity affects the fungus performance.
Laila Gasmi, Sehyeon Baek, Jong Cheol Kim, Sihyeon Kim, Mi Rong Lee, So Eun Park, Tae Young Shin, Se Jin Lee, Bruce L. Parker, Jae Su Kim   +9 more
doaj   +1 more source

Physical and functional interactions of cyclophilin B with neuronal actin and peroxiredoxin-1 are modified by oxidative stress.

, 2009
International audiencePresynaptic actin was identified as a new Torpedo cyclophilin B partner captured in pull-down experiments and by coimmunoprecipitation.
Morot-Gaudry-Talarmain, Yvette
core   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis

Frontiers in Immunology, 2020
Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy.Objective: To demonstrate whether IgM ...
Rita Carsetti, Rita Carsetti, Antonio Di Sabatino, Maria Manuela Rosado, Simona Cascioli, Eva Piano Mortari, Cinzia Milito, Ola Grimsholm, Alaitz Aranburu, Ezio Giorda, Francesco Paolo Tinozzi, Federica Pulvirenti, Giuseppe Donato, Francesco Morini, Pietro Bagolan, Gino Roberto Corazza, Isabella Quinti   +16 more
doaj   +1 more source

Human cellular restriction factors that target HIV-1 replication

BMC Medicine, 2009
Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell ...
Jeang Kuan-Teh, Luban Jeremy, Strebel Klaus   +2 more
doaj   +1 more source

Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin

Journal of Biological Chemistry, 1993
Calcineurin (CaN), a Ca2+/calmodulin-dependent serine/threonine phosphatase, has been shown to be inhibited by the complex of the immunosuppressant cyclosporin A (CsA) and its receptor, cyclophilin (CyP), but not by either alone. In the current study, the topological relationship between cyclophilin and the subunits of CaN has been explored using ...
W, Li, R E, Handschumacher
openaire   +2 more sources

Cyclophilin B Is a Functional Regulator of Hepatitis C Virus RNA Polymerase [PDF]

Molecular Cell, 2005
Viruses depend on host-derived factors for their efficient genome replication. Here, we demonstrate that a cellular peptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B (CyPB), is critical for the efficient replication of the hepatitis C virus (HCV) genome.
Watashi, Koichi, Ishii, Naoto, Hijikata, Makoto, Inoue, Daisuke, Murata, Takayuki, Miyanari, Yusuke, Shimotohno, Kunitada   +6 more
openaire   +2 more sources

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

Crystallisation and preliminary X-ray diffraction studies of cyclophilin-tetrapeptide and cyclophilin-cyclosporin complexes

, 1990
Recombinant human cyclophilin has been co-crystallised with a number of peptides to give crystals suitable for X-ray analysis. The crystal complexes for which heavy-atom derivatives have been prepared and X-ray data collected are: cyclophilin with N ...
Gaston Pfluegl, Mikol, Vincent, Joerg Kallen, Pfluegl, Gaston, Vincent Mikol, Malcolm D. Walkinshaw, Mauro Zurini, Kallen, Joerg, Johan N. Jansonius, Zurini, Mauro, Jansonius, Johan N., Walkinshaw, Malcolm D.   +11 more
core   +1 more source

The impact of Epstein‐Barr virus latent membrane protein 2A on the production of B cell activating factor of the tumor necrosis factor family (BAFF), APRIL and their receptors

Immunity, Inflammation and Disease, 2022
Introduction Epstein‐Barr virus (EBV) establishes a lifelong infection in human B cells where the virus consistently expresses Latent Membrane Protein 2A (LMP2A) to promote B cell survival.
Kevin Madayag, Ryan Incrocci, Michelle Swanson‐Mungerson   +2 more
doaj   +1 more source