Results 51 to 60 of about 31,607 (207)

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Role of Cyclophilin B in Activation of Interferon Regulatory Factor-3 [PDF]

Journal of Biological Chemistry, 2005
IRF-3 is a member of the interferon regulatory factors (IRFs) and plays a principal role in the induction of interferon-beta (IFN-beta) by virus infection. Virus infection results in the phosphorylation of IRF-3 by IkappaB kinase epsilon and TANK-binding kinase 1, leading to its dimerization and association with the coactivators CREB-binding protein ...
Yoko, Obata, Kazuo, Yamamoto, Masanobu, Miyazaki, Kunitada, Shimotohno, Shigeru, Kohno, Toshifumi, Matsuyama   +5 more
openaire   +2 more sources

Proteomic Alterations in B Lymphocytes of Sensitized Mice in a Model of Chemical-Induced Asthma. [PDF]

PLoS ONE, 2015
The role of B-lymphocytes in chemical-induced asthma is largely unknown. Recent work demonstrated that transferring B lymphocytes from toluene diisocyanate (TDI)-sensitized mice into naïve mice, B cell KO mice and SCID mice, triggered an asthma-like ...
Steven Haenen, Jeroen A J Vanoirbeek, Vanessa De Vooght, Liliane Schoofs, Benoit Nemery, Elke Clynen, Peter H M Hoet   +6 more
doaj   +1 more source

Involvement of cyclophilin B in the replication of Japanese encephalitis virus

Virology, 2011
Japanese encephalitis virus (JEV) is a mosquito-borne RNA virus that belongs to the Flaviviridae family. In this study, we have examined the effect of cyclosporin A (CsA) on the propagation of JEV. CsA exhibited potent anti-JEV activity in various mammalian cell lines through the inhibition of CypB.
Kambara, Hiroto, Tani, Hideki, Mori, Yoshio, Abe, Takayuki, Katoh, Hiroshi, Fukuhara, Takasuke, Taguwa, Shuhei, Moriishi, Kohji, Matsuura, Yoshiharu   +8 more
openaire   +2 more sources

Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype [PDF]

Journal of Molecular Cell Biology, 2020
Abstract Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition (pEMT), proliferation, and further redifferentiation into specialized tubule epithelial cells (TECs).
Eduard Sarró, Mónica Durán, Ana Rico, Diana Bou-Teen, Vanesa Fernández-Majada, Anthony J Croatt, Karl A Nath, Maria Teresa Salcedo, Justin H Gundelach, Daniel Batlle, Richard J Bram, Anna Meseguer   +11 more
openaire   +4 more sources

Lack of Cyclophilin B in Osteogenesis Imperfecta with Normal Collagen Folding [PDF]

New England Journal of Medicine, 2010
Osteogenesis imperfecta is a heritable disorder that causes bone fragility. Mutations in type I collagen result in autosomal dominant osteogenesis imperfecta, whereas mutations in either of two components of the collagen prolyl 3-hydroxylation complex (cartilage-associated protein [CRTAP] and prolyl 3-hydroxylase 1 [P3H1]) cause autosomal recessive ...
Aileen M, Barnes, Erin M, Carter, Wayne A, Cabral, MaryAnn, Weis, Weizhong, Chang, Elena, Makareeva, Sergey, Leikin, Charles N, Rotimi, David R, Eyre, Cathleen L, Raggio, Joan C, Marini   +10 more
openaire   +2 more sources

The Bursaphelenchus xylophilus effector BxML1 targets the cyclophilin protein (CyP) to promote parasitism and virulence in pine

BMC Plant Biology, 2022
Background Bursaphelenchus xylophilus is the causal agent of pine wilt disease (PWD) that has caused enormous ecological and economic losses in China. The mechanism in the interaction between nematodes and pine remains unclear. Plant parasitic nematodes (
Yan Zhang, Tong-Yue Wen, Xiao-Qin Wu, Long-Jiao Hu, Yi-Jun Qiu, Lin Rui   +5 more
doaj   +1 more source

Aberrant B Cell Receptor Signaling in Naïve B Cells from Patients with Idiopathic Pulmonary Fibrosis

Cells, 2021
Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease in which an impaired healing response to recurrent micro-injuries is thought to lead to fibrosis.
Stefan F. H. Neys, Peter Heukels, Jennifer A. C. van Hulst, Jasper Rip, Marlies S. Wijsenbeek, Rudi W. Hendriks, Odilia B. J. Corneth   +6 more
doaj   +1 more source

Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B. [PDF]

Proceedings of the National Academy of Sciences, 1992
The Ca(2+)- and calmodulin-dependent protein phosphatase calcineurin is inhibited by the immunosuppressant drug cyclosporin A in the presence of cyclophilin A or B. Of the two isoforms, cyclophilin B is more potent by a factor of 2-5 when either the phosphoprotein [32P]casein or the [32P]phosphoserine [Ser(32P)] form of the 19-residue bovine cardiac ...
S K, Swanson, T, Born, L D, Zydowsky, H, Cho, H Y, Chang, C T, Walsh, F, Rusnak   +6 more
openaire   +2 more sources

Receptor‐Mediated Transcytosis of Cyclophilin B Through the Blood—Brain Barrier [PDF]

Journal of Neurochemistry, 1999
Abstract: Cyclophilin B (CyPB) is a cyclosporin A (CsA)‐binding protein mainly located in intracellular vesicles and secreted in biological fluids. In previous works, we demonstrated that CyPB interacts with T lymphocytes and enhances in vitro cellular incorporation and activity of CsA.
Carpentier, Mathieu, Descamps, Laurence, Allain, Fabrice, Denys, Agnés, Durieux, Sandrine, Fenart, Laurence, Kieda, Claudine, Cecchelli, Roméo, Spik, Geneviève   +8 more
openaire   +3 more sources