Results 101 to 110 of about 35,749 (233)
Insights into the Roles of Cyclophilin A During Influenza Virus Infection
Viruses, 2013 Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the
Wenjun Liu, Zhendong Zhao, Xiaoling Liu
doaj +1 more source
Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury
The Journal of Physiology, EarlyView.Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich +5 more
wiley +1 more source
Study of Cyclophilin A Polymorphism in Women Patients with Cytomegalovirus Infections
Medical Journal of BabylonBackground: Cyclophilin A (CypA) is a highly conserved protein that is expressed in a wide range of tissues and cell types and plays roles in inflammation, oxidative stress, and viral infection.
Hawraa Ahmed Ali +2 more
doaj +1 more source
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
Functional Analysis of Interactions of Rotavirus NSP4 with Caveolin-1, Cyclophilin A, Cyclophilin 40, Heat Shock Protein 56, and Cholesterol [PDF]
, 2016 The rotavirus enterotoxin, NSP4, is responsible for early secretory diarrhea associated with rotavirus infection and is critical for RV replication and morphogenesis.
Yakshe, Krystle Ann
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Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability
The Journal of Physiology, EarlyView.Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi +12 more
wiley +1 more source
Cyclophilin A cooperates with MIP-2 to augment neutrophil migration
, 2011 Shannon J Heine1, Denise Olive1, Ji-Liang Gao2, Philip M Murphy2, Michael I Bukrinsky1, Stephanie L Constant11Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA; 2Laboratory of Molecular ...
Murphy PM +5 more
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Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis +5 more
wiley +1 more source
, 2018 Ming Zhang,1 Jingjing Tang,1 Jiafeng Yin,2 Xiaoying Wang,3 Xiangli Feng,1 Xia Yang,1 Hu Shan,1 Qiuhong Zhang,1 Jie Zhang,1 Yali Li1 1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University,
Yang X +9 more
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Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
, 2017 Cyclophilin inhibition has been a target for the treatment of hepatitis C and other diseases, but the generation of potent, drug-like molecules through chemical synthesis has been challenging.
Linos Lazarides (1494268) +22 more
core +2 more sources