Results 111 to 120 of about 35,749 (233)

Serum Angptl2 and CyPA Levels in Acute Myocardial Infarction and In-Stent Restenosis After Percutaneous Coronary Intervention: A Single-Center Retrospective Case-Control Study

Vascular Health and Risk Management
Pimo Zhou, Tai Yang, Hua Huang, Fang Tang, Peng Jin, Bo Zhou Department of Cardiovascular Medicine, Zhejiang Provincial People’s Hospital Bijie Hospital, Bijie City, Guizhou Province, People’s Republic of ChinaCorrespondence: Bo Zhou, Department of ...
Zhou P, Yang T, Huang H, Tang F, Jin P, Zhou B   +5 more
doaj  

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

PhD

, 2008
dissertationThe human protein, Cyclophilin A, is a member of a family of enzymes, known as peptidyl-prolyl isomerases, which catalyze cis-trans isomerization of proline peptide bonds. Because proline isomerization is a rate limiting step in the refolding
Vajdos, Felix Francis.
core  

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Crystallisation and preliminary X-ray diffraction studies of cyclophilin-tetrapeptide and cyclophilin-cyclosporin complexes

, 1990
Recombinant human cyclophilin has been co-crystallised with a number of peptides to give crystals suitable for X-ray analysis. The crystal complexes for which heavy-atom derivatives have been prepared and X-ray data collected are: cyclophilin with N ...
Gaston Pfluegl, Mikol, Vincent, Joerg Kallen, Pfluegl, Gaston, Vincent Mikol, Malcolm D. Walkinshaw, Mauro Zurini, Kallen, Joerg, Johan N. Jansonius, Zurini, Mauro, Jansonius, Johan N., Walkinshaw, Malcolm D.   +11 more
core   +1 more source

Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

eLife, 2017
RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I interferons (IFNs) against RNA virus infection. In this study, we found that cyclophilin A (CypA), a peptidyl-prolyl cis/trans isomerase, functioned as a ...
Wei Liu, Jing Li, Weinan Zheng, Yingli Shang, Zhendong Zhao, Shanshan Wang, Yuhai Bi, Shuang Zhang, Chongfeng Xu, Ziyuan Duan, Lianfeng Zhang, Yue L Wang, Zhengfan Jiang, Wenjun Liu, Lei Sun   +14 more
doaj   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

Cyclophilin polymorphism and virus infection

Current Opinion in Virology, 2015
Viruses are obligate intracellular parasites. All stages of their replication cycle depend on support by host-encoded factors. However, sequence variation also exists in host factors mostly in the form of single nucleotide polymorphisms (SNPs). Several coding and non-coding genetic variants in the PPIA gene encoding for CypA have been described, but ...
von Hahn, Thomas, Ciesek, Sandra
openaire   +2 more sources

The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi

, 1998
A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of
Antony P Page, Taylor, Paul, Page, Antony P., Holger Husi, Kontopidis, George, Husi, Holger, Paul Taylor, Walkinshaw, Malcolm D, Page, Antony P, Malcolm D Walkinshaw, Walkinshaw, Malcolm D., George Kontopidis   +11 more
core   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar, Amanda de Oliveira Matos, Daniel Francisco de Sousa, Jefferson do Carmo Dietz, Eugenio Damaceno Hottz, Marcelle Figueira Marques da Silva‐Sales, Helioswilton Sales‐Campos   +6 more
wiley   +1 more source