Results 131 to 140 of about 35,749 (233)

Nmr-studies of [u-c-13]cyclosporin-a Bound To Cyclophilin - Bound Conformation and Portions of Cyclosporine Involved In Binding

, 1991
Cyclosporin A (CsA), a potent immunosuppressant, is known to bind with high specificity to cyclophilin (CyP), a 17.7 kDa protein with peptidyl-prolyl isomerase activity.
M. JACKSON, R. HELFRICH, R. T. GAMPE, H. L. EATON, E. T. OLEJNICZAK, G. GEMMECKER, D. A. EGAN, R. EDALJI, J. HOCHLOWSKI, S. W. FESIK, R. SIMMER, NERI, Placido, T. F. HOLZMAN   +12 more
core   +1 more source

NMR assignments of mitochondrial cyclophilin Cpr3 from Saccharomyces cerevisiae

, 2016
Cyclophilins regulate protein folding, transport and signalling through catalysis of proline isomerization, and are ubiquitously expressed in both prokaryotes and eukaryotes.
TRIVEDI, D, KUMAR, A, HOSUR, RV, SHUKLA, VK, SINGH, JS   +4 more
core   +1 more source

Cyclophilin [PDF]

, 2016
Suchismita Roy, Prabhjeet Singh, Sneh Lata Singla-Pareek, Ashwani Pareek   +3 more
openaire   +1 more source

The activity of amyloid beta binding alcohol dehydrogenase in Alzheimer's disease

, 2012
The mitochondria are a vibrant hub for many problems that occur in Alzheimer’s disease. The enzyme amyloid-ß binding alcohol dehydrogenase (ABAD) and Cyclophilin D (CypD) are two key mitochondrial proteins that have essential functions in Alzheimer’s ...
Allen, Zoe Eleanor
core  

Molecular Characterization of Cyclophilin Protein Gene in Skin Normal Microflora: Malassezia furfur

Iranian Journal of Public Health, 2009
Background: Malassezia are dimorphic, lipid-dependent yeasts, which are responsible for causing several cutaneous and sys­temic conditions. Although cyclophilins (CyPs) are highly conserved cytosolic proteins that catalyze the peptidyl-prolyl cis-trans ...
M Moazeni , F Noorbakhsh, F Zaini , P Kordbacheh , J Hashemi , B Mousavi , L Andonian , S Rezaie   +7 more
doaj  

Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B

JCI Insight
Pathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit collagen synthesis have potential as antifibrotic agents.
Hope A. Flaxman, Maria-Anna Chrysovergi, Hongwei Han, Farah Kabir, Rachael T. Lister, Chia-Fu Chang, Robert Yvon, Katharine E. Black, Andreas Weigert, Rajkumar Savai, Alejandro Egea-Zorrilla, Ana Pardo-Saganta, David Lagares, Christina M. Woo   +13 more
doaj   +1 more source

Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa [PDF]

, 1988
Cyclophilin (cyclosporin A-binding protein) has a dual localization in the mitochondria and in the cytosol of Neurospora crassa. The two forms are encoded by a single gene which is transcribed into mRNAs having different lengths and 5' termini ...
Tropschug, Maximilian, Pfanner, Nikolaus, Hartl, Franz-Ulrich, Wachter, Elmar, Neupert, Walter, Köhler, Helmut, Nicholson, Donald W.   +6 more
core  

A yeast cyclophilin gene essential for lactate metabolism at high temperature

, 1992
The cyclophilins are a family of ubiquitous eukaryotic proteins first identified by high affinity for cyclosporin A (CsA). The immunosuppressant and cytotoxic effects of CsA are thought to result from formation of a toxic complex between cyclophilin and ...
Hall, M. N., Davis, E. S., Brennan, M. B., Becker, A., Heitman, J.   +4 more
core  

Cyclophilin [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Cyclophilin D at the Heart of Neonatal Hypoxia. [PDF]

JACC Basic Transl Sci
Gordon JW.
europepmc   +1 more source