Results 121 to 130 of about 35,749 (233)
Cyclophilin inhibitors as antiviral agents
Bioorganic & Medicinal Chemistry Letters, 2013 Cyclophilins (Cyps) are ubiquitous proteins that effect the cis-trans isomerization of Pro amide bonds, and are thus crucial to protein folding. CypA is the most prevalent of the ~19 human Cyps, and plays a crucial role in viral infectivity, most notably for HIV-1 and HCV.
Peel, Michael, Scribner, Andrew
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Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
, 1992 SUMMARY Autoantibodies against cyclophilin, a cyclosporin A binding protein, were detected in sera of 29 of 46 (63%) patients with systemic lupus erythematosus and 14 of 40 (35%) Lyme disease patients.
J CRAFT +4 more
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Progress of CypA and Lung Cancer-related Research
Chinese Journal of Lung Cancer, 2010 CypA is the most important member of Cyclophilins. It is a widely expressed protein in nature possessing PPIase and chaperone activities which help the precise folding of protein. Also, it is involved in immunosuppression, inflammation and the balance of
Zhe QIAN, Wentao YUE, Baolan LI
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BMC Research Notes, 2012 Background Hyperelastosis cutis is an inherited autosomal recessive connective tissue disorder. Affected horses are characterized by hyperextensible skin, scarring, and severe lesions along the back. The disorder is caused by a mutation in cyclophilin B.
Boudko Sergei P +5 more
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, 2023 The data in the article indicate cyclophilin A (CypA) as an adverse pro-inflammatory factor that negatively affects fetal development and is associated with pregnancy ...
Kalinina, A. +4 more
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Calmodulin, Cyclophilin, and Cyclosporin A [PDF]
Science, 1986 W N, Hait +2 more
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Cyclophilin A as negative regulator of apoptosis by sequestering cytochrome c.
, 2010 International audienceThe release of cytochrome c from the mitochondrial intermembrane space is a decisive event in programmed cell death. Once in the cytoplasm, cytochrome c is involved in the formation of the macromolecular complex termed apoptosome ...
Rio, Maguy Del +15 more
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Localization of cyclophilin A and cyclophilin C mRNA in murine kidney using RT-PCR
, 1994 Localization of cyclophilin A and cyclophilin C mRNA in murine kidney using RT-PCR. Cyclosporin A (CsA), which is widely used as an immunosuppressant, has a nephrotoxic side effect.
Otsuka, Masakazu +5 more
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Cyclophilin A in Cardiovascular Homeostasis and Diseases
The Tohoku Journal of Experimental Medicine, 2015 Vascular homeostasis is regulated by complex interactions between many vascular cell components, including endothelial cells, vascular smooth muscle cells (VSMCs), adventitial inflammatory cells, and autonomic nervous system. The balance between oxidant and antioxidant systems determines intracellular redox status, and their imbalance can cause ...
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HeliyonIntroduction: No markers have been used to diagnose historical peritoneal dialysis (PD)-related peritonitis. Cyclophilin A (CypA) is associated with glucose toxicity and inflammation.
Shang-Feng Tsai +3 more
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