Results 1 to 10 of about 49,424 (197)
Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology
Cells, 2021 Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade.
Ryan D. Readnower +4 more
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Hypereosinophilic Syndrome: A Case of Diagnostic and Therapeutic Difficulty
Sri Lanka Journal of Medicine, 2022 Hypereosinophilic syndrome (HES) is a condition with a diverse clinical presentation and prognosis. Due to its rarity, it is often under-recognized. We present a 48-year-old female patient who presented with eosinophilic pneumonia and bullous pemphigoid;
B. D. Alahakoon +4 more
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Immunosuppressive therapy as a risk factor for new-onset diabetes after transplantation
Терапевтический архив, 2020 Aim.To analyze the modes of immunosuppressive therapy as a risk factor for new-onset diabetes after transplantation (NODAT) in kidney recipients. Materials and methods.The retrospective analysis included data from 1367 recipients (755 men and 612 ...
S. S. Allazova +3 more
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Clinics in Dermatology, 1989 Cyclosporine A (CsA) is a neutral lipophilic compound that was first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide that consists of 11 amino acids and that has a molecular weight of 1202 daltons.1 It was found to have potent immunosuppressive properties and was initially used in the late 1970s to
Gupta, Aditya K. +7 more
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The genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster. [PDF]
PLoS Genetics, 2013 The ascomycete fungus Tolypocladium inflatum, a pathogen of beetle larvae, is best known as the producer of the immunosuppressant drug cyclosporin. The draft genome of T.
Kathryn E Bushley +12 more
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Immunosupressive therapy of aplastic anemia patients: successes and failures (single center experiment 2007–2016) [PDF]
Терапевтический архив, 2020 Treatment programs for patients with acquired aplastic anemia include two main therapeutic options: allogeneic bone marrow transplantation and combined immunosuppressive therapy (IST).
E. A. Mikhaylova +13 more
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Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Since arthritis induced by Mycobacterium products (adjuvant) in rats is considered to be immunologically driven, the objective of the present study was to determine if the immunosuppressor drug cyclosporin could affect hindpaw edema and joint ...
J.N. Francischi +2 more
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CYCLOSPORIN A (SANDIMMUN NEORAL) IN THERAPY FOR PSORIASIS AND PSORIATIC ARTHRITIS
Современная ревматология, 2010 The involvement of immune mechanisms in the pathogenesis of psoriatic arthritis (PA) is noted to give grounds to use immunoactive compounds (disease- modifying agents - basic anti-inflammatory drugs -BAIDs), such as cyclosporin A (CsA), in this disease ...
Yulia Leonodovna Korsakova
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CYCLOSPORIN A IN THERAPY FOR JUVENILE ARTHRITIS
Современная ревматология, 2010 The paper describes approaches to using cyclosporin A (CsA) in juvenile arthritis (JA). It shows the benefits of combination basic therapy with CsA and methotrexate included into a treatment regimen mainly for systemic JA and JA involving the eye ...
E S Fedorov, Svetlana Olegovna Salugina
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Pteridines, 2002 We examined the effect of immunosuppressant cyclosporin A (CsA) on the synthesis of tetrahydrobiopterin (BH4), which is a cofactor for nitric oxide synthase (NOS), during treatment with lipopolysaccharide (LPS) in mouse brain microvascular endothelial ...
Ishii Masakazu +5 more
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