Results 21 to 30 of about 49,424 (197)
Dental Research Journal, 2016 Background: To evaluate the effect of Cyclosporin A (CsA) and angiotensin II (Ang II) on cytosolic calcium levels in cultured human gingival fibroblasts (HGFs).
Ajitkumar Supraja +4 more
doaj +1 more source
Cyclosporine Nephrotoxicity [PDF]
Toxicologic Pathology, 1986 Cyclosporine (CSA) is a new immunosuppressant which has selectivity for the immune system and is without systemic side effects at therapeutic doses. In contrast to the cytotoxic class of immunosuppressants, no myelotoxic, teratogenic, mutagenic, or carcinogenic effects were observed.
B, Ryffel, M J, Mihatsch
openaire +2 more sources
Advanced Science, EarlyView.The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen +9 more
wiley +1 more source
Advanced Science, EarlyView.Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su +7 more
wiley +1 more source
Therapeutic Advances in Gastroenterology, 2020 The therapeutic management of patients with severe steroid-refractory ulcerative colitis still represents a critical clinical challenge. In this setting, cyclosporin is an effective and rapidly acting induction treatment that is applied in combination ...
Ingo Ganzleben +10 more
doaj +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Management of cerebral vasculopathy in sickle cell anemia (SCA) includes standard‐care, that is, chronic transfusion (CT) or hydroxyurea, and hematopoietic cell transplantation (HCT). DREPAGREFFE‐1 (December 2010/June 2013), a French multicenter trial, was the first prospective trial comparing standard‐care to match sibling donor (MSD)‐HCT in ...
Francoise Bernaudin +40 more
wiley +1 more source
Pathogens, 2019 As the prognosis of invasive aspergillosis remains unacceptably poor in patients undergoing hematopoietic stem cell transplantation (HSCT), there is a growing interest in the adoptive transfer of antifungal effector cells, such as Natural Killer (NK ...
Stanislaw Schmidt +3 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan +6 more
wiley +1 more source
Suppression of Coronavirus Replication by Cyclophilin Inhibitors
Viruses, 2013 Coronaviruses infect a variety of mammalian and avian species and cause serious diseases in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS), feline infectious peritonitis (FIP), mouse hepatitis, and avian infectious ...
Takashi Sasaki +2 more
doaj +1 more source
Lessons to Learn From Low-Dose Cyclosporin-A: A New Approach for Unexpected Clinical Applications
Frontiers in Immunology, 2019 Cyclosporin-A has been known and used for a long time, since its “fast track” approval in the early 80's. This molecule has rapidly demonstrated unexpected immunosuppressive properties, transforming the history of organ transplantation. Cyclosporin's key
Camila Flores +10 more
doaj +1 more source