Results 11 to 20 of about 827 (152)
Neural Regeneration Research, 2023 The mitochondrial permeability transition pore is a nonspecific transmembrane channel. Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling, calcium overload, and axonal degeneration ...
Yang Yang +12 more
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Cyclophilins and cyclophilin inhibitors in nidovirus replication
Virology, 2018 Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs, which can also block the replication of nidoviruses (arteriviruses and coronaviruses).
Adriaan H. de Wilde +3 more
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Cyclophilin‐B is an abundant protein whose conformation is similar to cyclophilin‐A [PDF]
FEBS Letters, 1994 Cyclophilin‐B (bCyP‐20) was isolated in a relatively high quantity from calf brain and spleen tissues consecutively applying weak cation exchange, chromatofocusing and strong cation exchange chromatographies. Edman degradation yielded the N‐terminal sequence NH2‐DEKKKGPKVTVK‐VYFDLRIGDEDIGRVVIGLFGKTVPKTVDNFVAL.
Galat, Andrzej, Bouet, Françoise
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Gene Therapy Strategies to Exploit TRIM Derived Restriction Factors against HIV-1
Viruses, 2014 Restriction factors are a collection of antiviral proteins that form an important aspect of the innate immune system. Their constitutive expression allows immediate response to viral infection, ahead of other innate or adaptive immune responses.
Emma Chan, Greg J. Towers, Waseem Qasim
doaj +1 more source
Cyclophilin A‐mediated mitigation of coronavirus SARS‐CoV‐2
Bioengineering & Translational Medicine, 2023 Human cyclophilin A (hCypA) is important for the replication of multiple coronaviruses (CoVs), and cyclosporine A inhibitors can suppress CoVs. The emergence of rapidly spreading severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants has ...
Simranjeet Singh Sekhon +8 more
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CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Science-Business eXchange, 2011 In vitro studies suggest cyclosporine A derivatives could help treat coronaviruses such as SARS.
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Non‐Immunosuppressive Cyclophilin Inhibitors
Angewandte Chemie International Edition, 2022 AbstractCyclophilins, enzymes with peptidyl‐prolyl cis/trans isomerase activity, are relevant to a large variety of biological processes. The most abundant member of this enzyme family, cyclophilin A, is the cellular receptor of the immunosuppressive drug cyclosporine A (CsA).
Cordelia Schiene‐Fischer +2 more
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Biotechnology & Biotechnological Equipment, 2019 The aim of this study was to investigate the effects of cyclophilin B on MC3T3-E1 cells and the underlying mechanism. CCK-8 assay was used to evaluate the cell activity, polymerase chain reaction to verify the overexpression of cyclophilin B, western ...
Fan Mei, Yanhong Tu
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Genome-Wide Analysis of Cyclophilin Proteins in 21 Oomycetes
Pathogens, 2019 Cyclophilins (CYPs), a highly-conserved family of proteins, belong to a subgroup of immunophilins. Ubiquitous in eukaryotes and prokaryotes, CYPs have peptidyl-prolyl cis−trans isomerase (PPIase) activity and have been implicated as virulence ...
Yan Zhang +4 more
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