Results 31 to 40 of about 827 (152)

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities

Biomolecules, 2017
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
doaj   +1 more source

Cyclophilin A Impairs Efferocytosis and Accelerates Atherosclerosis by Overexpressing CD 47 and Down-Regulating Calreticulin

Cells, 2021
Impairment of efferocytosis in apoptotic macrophages is a known determinant of the severity of atherosclerosis and the vulnerability of plaques to rupture. The precise mechanisms involved in impaired efferocytosis are unclear.
Vinitha Anandan, Thushara Thulaseedharan, Aishwarya Suresh Kumar, Karthika Chandran Latha, Amjesh Revikumar, Ajit Mullasari, Chandrasekharan C. Kartha, Abdul Jaleel, Surya Ramachandran   +8 more
doaj   +1 more source

Cyclophilin A and viral infections

Biochemical and Biophysical Research Communications, 2012
Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A. A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc ...
Zhou, Daijun, Mei, Qiang, Li, Jintao, He, Haiyang   +3 more
openaire   +2 more sources

The Arabidopsis Cyclophilin Gene Family [PDF]

Plant Physiology, 2004
AbstractDatabase searching has allowed the identification of a number of previously unreported single and multidomain isoform members of the Arabidopsis cyclophilin gene family. In addition to the cyclophilin-like peptidyl-prolyl cis-trans isomerase domain, the latter contain a variety of other domains with characterized functions.
Patrick G N, Romano, Peter, Horton, Julie E, Gray   +2 more
openaire   +2 more sources

Cyclophilin B serum levels present variations across the menstrual cycle

Scientific Reports, 2023
Cyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participates in hypoxia ...
Rebeca Alvariño, Cristina Gil-Mouce, Manuel A. Botana, Sandra Gegunde, Jesús González-Jartín, Mercedes R. Vieytes, Amparo Alfonso, Luis M. Botana   +7 more
doaj   +1 more source

Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B

Journal of General Virology, 2017
Feline coronavirus (FCoV) causes the fatal disease feline infectious peritonitis, which is currently incurable by drug treatment, and no effective vaccines are available. Cyclosporin A (CsA), a cyclophilin (Cyp) inhibitor, inhibits the replication of FCoV in vitro and in vivo as well as the replication of human and animal coronaviruses.
Tanaka, Yoshikazu, Sato, Yuka, Sasaki, Takashi   +2 more
openaire   +2 more sources

Isoform-Specific Inhibition of Cyclophilins [PDF]

Biochemistry, 2009
Cyclophilins belong to the enzyme class of peptidyl prolyl cis-trans isomerases which catalyze the cis-trans isomerization of prolyl bonds in peptides and proteins in different folding states. Cyclophilins have been shown to be involved in a multitude of cellular functions like cell growth, proliferation, and motility.
Sebastian, Daum, Michael, Schumann, Sebastian, Mathea, Tobias, Aumüller, Molly A, Balsley, Stephanie L, Constant, Boris Féaux, de Lacroix, Fabian, Kruska, Manfred, Braun, Cordelia, Schiene-Fischer   +9 more
openaire   +2 more sources

Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections

Viruses
Cyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the context of many viral infections including chronic hepatitis B and C.
Jennifer Molle, Sarah Duponchel, Jennifer Rieusset, Michel Ovize, Alexander V. Ivanov, Fabien Zoulim, Birke Bartosch   +6 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

Cell Reports, 2021
Summary: There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of ∼3,000 drugs.
Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Elisha Segrist, Minghua Li, Brinda Kamalia, Lauren Castellana, Kasirajan Ayyanathan, Fabian L. Cardenas-Diaz, Edward E. Morrisey, Rachel Truitt, Wenli Yang, Kellie Jurado, Kirandeep Samby, Holly Ramage, David C. Schultz, Sara Cherry   +16 more
doaj   +1 more source