Results 91 to 100 of about 154,825 (291)

Clinical factors associated with pneumocystis pneumonia despite its primary prophylaxis: When to stop prophylaxis?

Arthritis &Rheumatology, Accepted Article.
Objective Although previous studies show that primary prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is effective in patients with rheumatic diseases receiving immunosuppressive treatment, there is limited evidence regarding the optimal timing for prophylaxis withdrawal.
Ju Yeon Kim, Se Rim Choi, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Jun Won Park   +5 more
wiley   +1 more source

Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs

Molecular Therapy: Nucleic Acids, 2013
MGH2.1 is a herpes simplex virus type 1 (HSV1) oncolytic virus that expresses two prodrug-activating transgenes: the cyclophosphamide (CPA)-activating cytochrome P4502B1 (CYP2B1) and the CPT11-activating secreted human intestinal carboxylesterase (shiCE).
Kazue Kasai, Hiroshi Nakashima, Fang Liu, Samantha Kerr, Jiang Wang, Mitch Phelps, Philip M Potter, William B Goins, Soledad A Fernandez, E Antonio Chiocca   +9 more
doaj   +1 more source

Organ toxicities associated with diet‐induced obesity in rats: Investigation of changes in activities selected enzymes

Biotechnology and Applied Biochemistry, EarlyView.
Abstract Obesity stands out as one of the most significant health problems in the modern world. The prevalence of high‐calorie diets (HCDs) globally exacerbates this condition. Throughout history, plants and plant‐derived food products have been utilized for medicinal purposes, demonstrating their efficacy in the treatment and prevention of various ...
Bedia Bati
wiley   +1 more source

Protective Effects of Galbanum Essential Oil on Histomorphometric Changes in Placenta of Cyclophosphamide Treated Rat

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2016
BACKGROUND AND OBJECTIVE: Cyclophosphamide is a drug widely used to treat cancer, skin diseases and immune system disorders. Since cyclophosphamide passes placenta during pregnancy and causes disorders in fetus, this study was conducted to assess the ...
Z Rezaei, T Mohammadi, M Khaksarimahabadi, H Najafzadeh   +3 more
doaj  

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Influence of Renal Function on Phosphoramide Mustard Exposure: A Nonlinear Mixed‐Effects Analysis

The Journal of Clinical Pharmacology, Volume 63, Issue 1, Page 135-142, January 2023., 2023
Abstract Phosphoramide mustard (PM) is the final cytotoxic metabolite formed from the parent compound cyclophosphamide through a complex metabolic pathway, primarily through hepatic metabolism. Little is known about the effect of renal elimination on the disposition of PM.
Mutaz M. Jaber, Takuto Takahashi, Mark N. Kirstein, Mahmoud Al‐Kofahi, Pamala A. Jacobson, Richard C. Brundage   +5 more
wiley   +1 more source

Cyclophosphamide in Hodgkin's Disease and Related Disorders [PDF]

, 1960
J. Q. Matthias, J J Misiewicz, R. B. Scott   +2 more
openalex   +1 more source

Reduced exercise capacity is associated with left ventricular systolic dysfunction in long‐term survivors of allogeneic hematopoietic stem‐cell transplantation

Journal of Clinical Ultrasound, Volume 51, Issue 1, Page 5-15, January 2023., 2023
Exercise intolerance is a common complication in long‐term survivors of allogeneic hematopoietic stem‐cell transplantation. In this study, we found reduced oxygen uptake (VO2peak) by cardio‐pulmonary exercise tests to be associated with left ventricular systolic dysfunction by echocardiography.
Richard John Massey, Ole Henrik Myrdal, Phoi Phoi Diep, Marta Maria Burman, Lorentz Brinch, Lars Lysgaard Gullestad, Ellen Ruud, Svend Aakhus, Jan Otto Beitnes   +8 more
wiley   +1 more source

The Production of Tolerance to Human Erythrocytes in the Rat with Cytosine Arabinoside or Cyclophosphamide [PDF]

, 1969
Robert O. Gordon, Maclyn E. Wade, Malcolm S. Mitchell   +2 more
openalex   +1 more source

Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumors [PDF]

, 1969
John J. Costanzi, Charles A. Coltman, Lt Col   +2 more
openalex   +1 more source