Results 101 to 110 of about 203,753 (294)

Shengxian decoction alleviates cyclophosphamide-induced immunosuppression via improving B cell-mediated immune responses

Frontiers in Pharmacology
BackgroundChemotherapy is a prevalent and extensively utilized cancer treatment modality. However, it can result in immunosuppression. Shengxian Decoction (SXD) is a Traditional Chinese Medicine formula that has been demonstrated to improve ...
Chengyu Yang, Chengyu Yang, Ya Xu, Ya Xu, Fenfang Gong, Fenfang Gong, Silu Li, Silu Li, Huang Zhan, Huang Zhan, Zhixuan Huang, Zhixuan Huang, Maolin Wang, Maolin Wang, Hui Li, Hui Li, Hui Li, Hengjun Huang, Hengjun Huang   +18 more
doaj   +1 more source

Unravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats

Drug Design, Development and Therapy, 2021
Yinhua Wang,1 Zhaoling Zou,1 Amit Jaisi,2 Opeyemi Joshua Olatunji3 1The Second Peoples Hospital of Wuhu, Wuhu, 241001, Anhui, People’s Republic of China; 2School of Pharmacy, Walailak University, Nakhon Si Thammarat, 80160, Thailand; 3Faculty of Thai ...
Wang Y, Zou Z, Jaisi A, Olatunji OJ
doaj  

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Hepatorenoprotective effects of Lepidium draba L. extracts against cyclophosphamide-induced oxidative injuries in rats via reducing apoptosis and inflammation

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the protective effects of Lepidium draba L. (L. draba) on cyclophosphamide (CP)-induced hepatotoxicity and nephrotoxicity in rats.
Yu-Lai You, Sheng Zheng, Cheng-Jian Zhao, Ye-Fei Chang, Pei Liu, Xue-Li Zeng, Lian Liu   +6 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Furosemide for prevention of cyclophosphamide-associated sterile haemorrhagic cystitis in dogs receiving metronomic low-dose oral cyclophosphamide [PDF]

, 2017
Sterile haemorrhagic cystitis (SHC) is a known risk of cyclophosphamide treatment. Diuresis using furosemide is effective in canines when maximally tolerated dosed cyclophosphamide is administered.
Wang, P., Wyatt, K., Ma, M., Setyo, L., Bunn, T.   +4 more
core  

Could we abandon cyclophosphamide in systemic vasculitis and lupus nephritis? [PDF]

, 2013
Cyclophosphamide has greatly improved prognosis in antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) and proliferative lupus nephritis (LN).
Kallenberg, Cees G. M.
core   +1 more source

Does cyclophosphamide benefit relapsing thrombotic thrombocytopenic purpura? [PDF]

, 2002
Thrombotic thrombocytopenic purpura (TTP) is a rare disease. A high index of suspicion is required for early diagnosis and treatment. It can present in acute as well as chronic forms.
Aggarwal, Amita, Agarwal, V., Sharma, B. L., Misra, R.   +3 more
core   +2 more sources

The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta‐Analysis of the European Myeloma Network (EMN)

American Journal of Hematology, EarlyView.
Our meta‐analysis showed significant improvement of PFS with lenalidomide, proteasome inhibitors, and CD38‐based therapies. A significant OS benefit was noted only with lenalidomide in transplant‐eligible (TE) patients, while CD38‐directed therapy showed a trend toward improved OS.
Heinz Ludwig, Evangelos Terpos, Francesca Gay, Niels W. C. J. van de Donk, Sarah Bernhard, Monika Engelhardt, Gordon Cook, Fredrik Schjesvold, Hermann Einsele, Graham Jackson, Charlotte Pawlyn, María‐Victoria Mateos, Sonja Zweegman, Martin Schreder, Meral Beksaç, Christoph Driessen, Enrique M. Ocio, Rakesh Popat, Leo Rasche, Cyrille Touzeau, Pellegrino Musto, Annemiek Broijl, Meletios Dimopoulos, Roman Hajek, Mario Boccadoro, Pieter Sonneveld   +25 more
wiley   +1 more source

Use of testosterone to prevent cyclophosphamide-induced azoospermia [PDF]

, 1997
BACKGROUND: Prepubertal patients receiving chemotherapy are relatively resistant to cyclophosphamide-induced germinal cell alterations. OBJECTIVE: To study the possible protective effect of testosterone used to inhibit germinal cell activity in ...
MASALA, Antonio Giovanni Emilio, Faedda R, Ivaldi R, Alagna S, Lai E, Chiarelli G, SATTA, Andrea Ercole, Taras MS, Bartoli E., Rovasio PP   +9 more
core