ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl +6 more
wiley +1 more source
Diabetes Mellitus in Post-renal Transplant and Nephrotic Syndrome Children on Tacrolimus: (Case Report). [PDF]
Moghtaderi M, Moghadam SS.
europepmc +1 more source
Effective Management of Recalcitrant Hailey–Hailey Disease With Risankizumab
International Journal of Dermatology, EarlyView.
Joy Justice +3 more
wiley +1 more source
ABSTRACT Erythrokeratodermia cardiomyopathy (EKC) syndrome is a rare autosomal dominant disorder characterized by generalized erythrokeratoderma and progressive dilated cardiomyopathy, caused by pathogenic variants in the SR6 domain of desmoplakin (DSP).
Sepideh Hamzehlou +7 more
wiley +1 more source
Targeting the IL-36 Pathway: Spesolimab as a Therapeutic for Acute Flares of Pustular Psoriasis. [PDF]
Nwozo E, Cross D, Smith D.
europepmc +1 more source
Antibody Serologies and Diagnostic Considerations in Reactive Infectious Mucocutaneous Eruption
ABSTRACT Reactive infectious mucocutaneous eruption (RIME) is an uncommon, post‐infectious mucocutaneous condition often associated with Mycoplasma pneumoniae, but which can be triggered by other pathogens. We retrospectively reviewed eight young adult patients diagnosed with RIME over a 10‐year period, all of whom had positive Mycoplasma pneumoniae ...
Aaron D. Smith +5 more
wiley +1 more source
CNI Trough Variability Does Not Reliably Reflect Medication Adherence: Insights From a 3-Year Follow-Up Study. [PDF]
Villeneuve C +10 more
europepmc +1 more source
TNF Inhibitor Therapy in Corticosteroid‐Resistant or ‐Dependent Pediatric Neutrophilic Dermatosis
ABSTRACT Neutrophilic dermatoses are rare in children. Systemic corticosteroids are the first‐line treatment, but guidelines for second‐line therapies are lacking. We report five cases of children with systemic steroid‐resistant/dependent neutrophilic dermatoses, successfully treated with tumor necrosis factor inhibitors.
Laure Chêne +7 more
wiley +1 more source
Insights into Severe Cutaneous Adverse Drug Reactions: A 5-Year Retrospective Analysis of Stevens- Johnson Syndrome- Toxic Epidermal Necrolysis and Drug Rash with Eosinophilia and Systemic Symptoms. [PDF]
Kumaran MS +5 more
europepmc +1 more source

