Results 231 to 240 of about 5,682 (266)

Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse

Toxicon, 2002
Cylindrospermopsin (CYN) is a hepatotoxin isolated from the blue-green alga Cylindrospermopsis raciborskii. The role of both glutathione (GSH) and the cytochrome P450 enzyme system (P450) in the mechanism of toxicity of CYN has been previously investigated in in vitro systems. We have investigated the role of GSH and P450 in vivo in mice.
Norris, R., Seawright, A., Shaw, G., Senogles, P., Eaglesham, G., Smith, M., Chiswell, R., Moore, M.   +7 more
openaire   +4 more sources

Evaluation of the intestinal permeability and cytotoxic effects of cylindrospermopsin

Toxicon, 2014
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in ecological and human risk.
Diego A. Fernández, M. Carmen Louzao, Natalia Vilariño, Maria Fraga, Begoña Espiña, Mercedes R. Vieytes, Luis M. Botana   +6 more
openaire   +3 more sources

Distribution of 14C cylindrospermopsin in vivo in the mouse

Environmental Toxicology, 2001
AbstractRadiolabelled 14C cylindrospermopsin (CYN) has been prepared and used to investigate the distribution and excretion of CYN in vivo in male Quackenbush mice. At a dose of 0.2 mg/kg (i.e., approx. median lethal dose) the following mean (SD) urinary and faecal recoveries (cumulative) were obtained, respectively: (0–6 hours, n=4) 48.2 (29.3)%, 11.9
Norris, R.G.L., Seawright, A.A., Shaw, Glendon Reginald, Smith, M.J., Chiswell, R.K., Moore, M.R.   +5 more
openaire   +4 more sources

Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii

Environmental Toxicology, 1999
Cylindrospermopsin (CYN) is a hepatotoxic alkaloid found in the blue-green alga Cylindrospermopsis raciborskii (C. raciborskii). Data indicating CYN alone does not account for the toxicity of freeze dried cultures of C. raciborskii have been presented recently.
Robyn K. Chiswell, Greg Pierens, Ross Norris, Geoffrey K. Eaglesham, M. J. Smith, Michael R. Moore, Glen R. Shaw, Alan A. Seawright   +7 more
openaire   +2 more sources

Investigating the production and release of cylindrospermopsin and deoxy-cylindrospermopsin by Cylindrospermopsis raciborskii over a natural growth cycle

Harmful Algae, 2014
Many harmful cyanobacterial genera have strains that can produce potent toxins and other biologically active compounds that present a risk to the health of humans and other animals that consume or contact contaminated water. Cylindrospermopsins (CYNs) are produced by several species of cyanobacteria including Cylindrospermopsis raciborskii (Woloszynska)
Gregory L. Boyer, Michele A. Burford, Philip T. Orr, Philip T. Orr, Timothy W. Davis   +4 more
openaire   +4 more sources

TiO2 photocatalytic degradation and detoxification of cylindrospermopsin

Journal of Photochemistry and Photobiology A: Chemistry, 2015
Abstract Cylindrospermopsin (CYN), a problematic potent cyanotoxin, is produced during harmful algal blooms and its presence in fresh water lakes and rivers is a threat to human health. UV TiO2 photocatalysis leads to the rapid degradation of CYN following pseudo-first-order kinetics.
Dionysios D. Dionysiou, Lin Chen, Cen Zhao, Kevin E. O'Shea   +3 more
openaire   +2 more sources

Natural Photodegradation of the Cyanobacterial Toxins Microcystin and Cylindrospermopsin

Environmental Science & Technology, 2010
Microcystins (MC) and cylindrospermopsin (CYN) are potent toxins produced by diverse cyanobacterial genera found in waterbodies throughout the world. In the present study, and in order to achieve a better understanding of the fate of cyanobacterial toxins in the environment, we assessed the photodegradation of MC and CYN along the water column and by ...
Antonio Quesada, Maria Huerta-Fontela, Samuel Cirés, Lars Wörmer, David Carrasco   +4 more
openaire   +3 more sources

Cylindrospermopsin effects on protein profile of HepG2 cells

Toxicology Mechanisms and Methods, 2016
Human hepatoma cells (HepG2) were exposed to purified cylindrospermopsin (CYN), a potent toxicant for eukaryotic cells produced by several cyanobacteria. Exposure to 10 μg l-1 of CYN for 24 h resulted in alteration of expression of 48 proteins, from which 26 were identified through mass spectrometry.
Sonia Regina Grötzner, Samuel Liebel, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro, Daniele Dietrich Moura Costa, Marco Antonio Ferreira Randi   +5 more
openaire   +2 more sources

ChemInform Abstract: The Synthesis and Biological Activity of the Marine Metabolite Cylindrospermopsin

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Patrick J. Murphy, Clive W. Thomas
openaire   +3 more sources

Electrochemical Investigation of DNA Interactions with Cyanobacterial Toxins: Cylindrospermopsin and Saxitoxin

ChemistrySelect
Anthropogenic eutrophication threatens freshwater sources used for agricultural irrigation and increases the occurrence risk of cyanotoxins, such as cylindrospermopsin (CYN) and saxitoxin (STX).
Ece Kesici‐Meco, Mete Yilmaz, Ece Unur‐Yilmaz   +2 more
semanticscholar   +1 more source