Results 231 to 240 of about 5,815 (271)

A biomimetic approach to the cylindrospermopsin alkaloids

Chemical Communications, 2011
The tethered Biginelli condensation between hemiaminal 21 and β-keto ester 22 is reported, leading to a model tricyclic core of the cylindrospermopsin alkaloids.
Daniel M, Evans, Patrick J, Murphy
openaire   +2 more sources

Cylindrospermopsin effects on protein profile of HepG2 cells

Toxicology Mechanisms and Methods, 2016
Human hepatoma cells (HepG2) were exposed to purified cylindrospermopsin (CYN), a potent toxicant for eukaryotic cells produced by several cyanobacteria. Exposure to 10 μg l-1 of CYN for 24 h resulted in alteration of expression of 48 proteins, from which 26 were identified through mass spectrometry.
Samuel, Liebel, Sonia, Regina Grötzner, Daniele, Dietrich Moura Costa, Marco, Antônio Ferreira Randi, Ciro, Alberto de Oliveira Ribeiro, Francisco, Filipak Neto   +5 more
openaire   +2 more sources

First occurrence of cylindrospermopsin in freshwater in France

Environmental Toxicology, 2008
AbstractEleven waterbodies in Western France dominated by cyanobacteria of the genera Aphanizomenon and Anabaena were analyzed in September 2006 for microcystins (MC) and cylindrospermopsin (CYN). CYN was detected for the first time in France in four of them in the presence of Aphanizomenon flos‐aquae and in the presence of Anabaena planctonica in the ...
Brient, Luc, Lengronne, Marion, Bormans, Myriam, Fastner, Jutta   +3 more
openaire   +4 more sources

Photonic Aptasensor Based on the Smart Cholesteric Liquid Crystal Network Structure for Cylindrospermopsin Detection.

Analytical Chemistry
Solid-state cholesteric liquid crystals (CLCsolid) with one-dimensional photonic structure offer a promising platform for constructing chemical and biological optical sensors, owing to their facile fabrication, signal readout, and sensitive and selective
Saddam Hussain, Hamad Abdulaziz Albaqami, Moahammed Zourob   +2 more
semanticscholar   +1 more source

Grazer‐induced toxin production is energetically costly and significantly reduces growth of cylindrospermopsin‐producing cyanobacteria

Limnology and Oceanography
Toxins have been proposed as a defense mechanism for phytoplankton against zooplankton grazing. However, the associated costs are not understood.
Lamei Lei, Wei Liu, Zihan Chen, Liang Peng, Li‐Juan Xiao, Bo-Ping Han, B. A. Neilan   +6 more
semanticscholar   +1 more source

ChemInform Abstract: Total Synthesis of (.+‐.)‐Cylindrospermopsin.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chaoyu Xie, Maria T. C. Runnegar, Barry B. Snider   +2 more
openaire   +1 more source

HPLC-PDA detection of cylindrospermopsin—opportunities and limits

Water Research, 2002
The cyanobacterial hepatotoxic alkaloid cylindrospermopsin (CYL) is of increased concern to public health due to the spreading of its main producer, Cylindrospermopsis raciborskii, around the globe. Here we present results of an evaluation of the possibility to analyse environmental samples for their content of CYL based on HPLC with photo diode array ...
Martin, Welker, Heike, Bickel, Jutta, Fastner   +2 more
openaire   +2 more sources

TiO2 photocatalytic degradation and detoxification of cylindrospermopsin

Journal of Photochemistry and Photobiology A: Chemistry, 2015
Abstract Cylindrospermopsin (CYN), a problematic potent cyanotoxin, is produced during harmful algal blooms and its presence in fresh water lakes and rivers is a threat to human health. UV TiO2 photocatalysis leads to the rapid degradation of CYN following pseudo-first-order kinetics.
Lin Chen, Cen Zhao, Dionysios D. Dionysiou, Kevin E. O’Shea   +3 more
openaire   +1 more source

Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells

Toxicology in Vitro, 2013
The newly emerging cyanotoxin cylindrospermopsin (CYN) is showing genotoxic effects in a range of test systems. However, the knowledge on the mechanisms involved is limited. To get insight into the cellular responses to CYN a toxicogenomic analysis of selected genes commonly affected by genotoxic stress was performed on HepG2 cells exposed to a non ...
Alja, Straser, Metka, Filipič, Bojana, Zegura   +2 more
openaire   +2 more sources

Cylindrospermopsin decreases the oxidative burst capacity of human neutrophils

Toxicon, 2014
Cylindrospermopsin (CYN), a cyanobacterial toxin, presents a risk to human health due to its relatively high chemical stability, a global spread of its producers and its occurrence in drinking-water reservoirs. Despite a broad interest in its toxicity to eukaryotes, little is known about the potential effects of CYN on the human immune system. Here, we
Barbara, Poniedziałek, Piotr, Rzymski, Jacek, Karczewski   +2 more
openaire   +2 more sources