Results 211 to 220 of about 10,369 (237)

Metabolism of Vitamin D3 by Human CYP27A1

Biochemical and Biophysical Research Communications, 2000
Human vitamin D(3) 25-hydroxylase (CYP27A1) cDNA was expressed in Escherichia coli, and its enzymatic properties were revealed. The reconstituted system containing the membrane fraction prepared from the recombinant E. coli cells was examined for the metabolism of vitamin D(3).
N, Sawada, T, Sakaki, M, Ohta, K, Inouye
openaire   +2 more sources

Case Report: a novel CYP27A1 gene variant in a patient with cerebrotendinous xanthomatosis with unusual clinical findings

International Journal of Neuroscience, 2023
Purpose/aim of the study Cerebrotendinous xanthomatosis is a disease with important clinical and molecular heterogeneity. CYP27A1 gene was described as the cause of these defects, with more than 50 mutations involved in the disease. The objective of this
Francisco A Tama Viteri, David Cotán Marín, Francisco A. Tama Sánchez, Marcia A. Tama Sánchez   +3 more
semanticscholar   +1 more source

Novel sterols synthesized via the CYP27A1 metabolic pathway

Archives of Biochemistry and Biophysics, 2003
A major biologic role of the ubiquitous mitochondrial P450 enzyme CYP27A1 is the generation of ligands such as 27-hydroxycholesterol and 3 beta-hydroxy-5-cholestenoic acid, which regulate the expression of nuclear receptors that govern many aspects of cholesterol homeostasis.
Irina, Pikuleva, Norman B, Javitt
openaire   +2 more sources

Cloning and Characterization of Cyp7a1 and Cyp27a1 Genes from the Non-Parasitic Japanese Lamprey Lethenteron reissneri

Zoological Science, 2023
Two cytochrome P450 genes homologous to human CYP7A1 and CYP27A1 were cloned from the non-parasitic Japanese lamprey Lethenteron reissneri. Lamprey cyp7a1 mRNA had varied expression levels among individuals: about four orders of magnitude differences in ...
Mayako Morii, Taku Hebiguchi, R. Watanabe, H. Yoshino, Y. Mezaki   +4 more
semanticscholar   +1 more source

Human CYP27A1 catalyzes hydroxylation of β-sitosterol and ergosterol

Biological Chemistry, 2016
Abstract β-Sitosterol and ergosterol are the equivalents of cholesterol in plants and fungi, respectively, and common sterols in the human diet. In the current work, both were identified as novel CYP27A1 substrates by in vitro experiments applying purified human CYP27A1 and its redox partners adrenodoxin (Adx) and adrenodoxin reductase ...
Maximilian, Ehrhardt, Adrian, Gerber, Josef, Zapp, Frank, Hannemann, Rita, Bernhardt   +4 more
openaire   +2 more sources

Mutation in CYP27A1 identified in family with coronary artery disease

European Journal of Medical Genetics, 2013
Coronary artery disease (CAD) is a leading cause of death worldwide. Myocardial infarction is the most severe outcome of CAD. Despite extensive efforts, the genetics of CAD is poorly understood. We aimed to identify the genetic cause of CAD in a pedigree with several affected individuals.
Kolsoum, Inanloorahatloo, Amir Farhang, Zand Parsa, Klaus, Huse, Paniz, Rasooli, Saeid, Davaran, Matthias, Platzer, Jian-Bing, Fan, Sasan, Amini, Frank, Steemers, Elahe, Elahi   +9 more
openaire   +2 more sources

The tumor‐repressing effect of CYP27A1 on renal cell carcinoma by 27‐HC arising from cholesterol metabolism

The FASEB Journal, 2022
As a key approach to mediate cholesterol metabolism, the role of the CYP27A1/27‐HC axis in renal cell carcinoma (RCC) remains unclear. Analysis of CYP27A1 expression from public databases and metastatic cases in our center suggested that CYP27A1 was ...
Xingming Zhang, X. Yin, Jindong Dai, G. Sun, Haoran Zhang, Jiayu Liang, Jinge Zhao, Sha Zhu, Junru Chen, Xudong Zhu, Y. Ni, Zhipeng Wang, Zhenhua Liu, N. Chen, P. Shen, H. Zeng   +15 more
semanticscholar   +1 more source

Four novel CYP27A1 mutations in seven Italian patients with CTX

European Journal of Neurology, 2010
Background and purpose:  Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disease, because of sterol 27‐hydroxylase deficiency. Clinical manifestations of CTX are tendon xanthomas, juvenile cataracts, osteoporosis, diarrhoea and multiple progressive neurological dysfunctions.
Gallus, G. N., Dotti, Maria, Mignarri, A., Rufa, Alessandra, Da Pozzo, P., Cardaioli, E., Federico, Antonio   +6 more
openaire   +4 more sources

COMPUTER SIMULATION OF THE PROCESSES COMPLEXATION BETWEEN NEW DERIVATIVES OF QUINAZOLINE-4(3H)-ONE, QUINAZOLINE-2,4(1H,3H)-DIONE AND CYTOCHROME P-450 STEROL-7Α-HYDROXYLASE(CYP27A1) WHEN STUDYING THEIR ANTIMICROBIAL EFFECTS AGAINST KLEB.PNEUMONIAE

Problems of Biological Medical and Pharmaceutical Chemistry
Introduction. Multi-resistance of Klebsiella pneumoniae to known antimicrobial agents determines the need for urgent development of new drugs ex-hibiting an antibacterial effect.
M. Samotrueva, A. Starikova, N. Zolotareva, A. Tsibizova, A. Yasenyavskaya, I. Temerev, D. Merezhkina, A. Borischuk, A. Ozerov   +8 more
semanticscholar   +1 more source

Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2003
The metabolism of 25-hydroxyvitamin D(3) was studied with a crude mitochondrial cytochrome P450 extract from pig kidney and with recombinant human CYP27A1 (mitochondrial vitamin D(3) 25-hydroxylase) and porcine CYP2D25 (microsomal vitamin D(3) 25-hydroxylase).
Zufan, Araya, Fardin, Hosseinpour, Karl, Bodin, Kjell, Wikvall   +3 more
openaire   +2 more sources