Results 1 to 10 of about 20,284 (182)
Association between CYP2C19 gene polymorphisms and Helicobacter pylori infection in Hainan region [PDF]
BMC Infectious DiseasesObjective This study was to investigate CYP2C19 gene and their association with H. pylori infection in the region of Hainan. Methods We conducted CYP2C19 genotype analysis in Hainan.
Shimei Huang +8 more
doaj +2 more sources
In vitro assessment of the impact of 30 CYP2C19 variants on citalopram metabolism [PDF]
PeerJBackground CYP2C19 polymorphisms are correlated with individual variability in response to citalopram treatment. The pharmacogenomic testing of CYP2C19 has been shown to optimize the safety and efficacy of citalopram medication. Exploration of the effect
Peng Wang, Xiao-xia Hu, Jun-wei Li
doaj +3 more sources
Clinical and Translational ScienceVoriconazole is the cornerstone of the treatment and prevention of fungal infections. While there is a good correlation between CYP2C19 genotype and voriconazole exposure during prophylactic treatment, no correlation was found in patients with invasive ...
Sylvia D. Klomp +6 more
doaj +5 more sources
PharmVar GeneFocus: CYP2C19 [PDF]
Clinical Pharmacology & Therapeutics, 2020 The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications.
Botton, Mariana R. +14 more
openaire +2 more sources
Effect of CYP2C19 genotypes on tamoxifen metabolism and early-breast cancer relapse
Scientific Reports, 2021 CYP2C19*2 and CYP2C19*17 might influence tamoxifen metabolism and clinical outcome. Our aim was to investigate the effect of CYP2C19 genotypes on tamoxifen concentrations and metabolic ratios (MRs) and breast cancer recurrence in a large cohort of ...
A. B. Sanchez-Spitman +5 more
doaj +1 more source
Distribution of a novel CYP2C haplotype in Native American populations
Frontiers in Genetics, 2023 The CYP2C19 gene, located in the CYP2C cluster, encodes the major drug metabolism enzyme CYP2C19. This gene is highly polymorphic and no-function (CYP2C19*2 and CYP2C19*3), reduced function (CYP2C19*9) and increased function (CYP2C19*17) star alleles ...
Vanessa Câmara Fernandes +4 more
doaj +1 more source
The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong +11 more
doaj +1 more source
Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment ...
Navid Neyshaburinezhad +4 more
doaj +1 more source
Bagcilar Medical Bulletin, 2021 Objective:The CYP2C19*1 has an entirely normal activity allele whose clopidogrel metabolism is normal. CYP2C19*2 called as non-functional alleles. In this study, we aimed to establish the CYP2C19*1 and CYP2C19*2 genotype frequencies both in Turkish ...
Ramazan Sabırlı +3 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2023 Aim. Study of the association of polymorphic variants of CYP2C19 (G681A), P2RY12 (H1/H2), ITGB3 (T1565C), ITGA2 (C807T), eNOS3 (T786C) genes with high residual platelet reactivity (HRPR) to clopidogrel and acetylsalicylic acid (ASA) at different terms of
T. P. Pronko +3 more
doaj +1 more source