Results 1 to 10 of about 36,503 (286)
CYP2C19 genotype and the PPIs – focus on rabeprazole [PDF]
Journal of Gastroenterology and Hepatology, 2005 Abstract: Amongst all the proton pump inhibitors (PPI), the hepatic metabolism of rabeprazole is least dependent on the CYP4502C19 system. Rabeprazole is therefore the PPI least affected by CYP4502C19 genetic polymorphism. This unique feature of rabeprazole complements rabeprazole's fast onset of action, and may lead to profound and consistent ...
Paul Lim +2 more
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In vivo inhibition of CYP2C19 but not CYP2D6 by fluvoxamine [PDF]
British Journal of Clinical Pharmacology, 1996 Studies were performed in eight healthy extensive metabolizers of mephenytoin and debrisoquine to determine the effect of fluvoxamine on the activities of S‐mephenytoin 4′‐hydroxylase (CYP2C19) and metoprolol α‐hydroxylase (CYP2D6). Therapeutic dosing with fluvoxamine (100 mg day−1) for 2 weeks caused a significant increase in the 0–8 h urinary S/R ...
Zhenhua Xu +2 more
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Hydroxylation of lansoprazole in poor metabolizers of CYP2C19 [PDF]
British Journal of Clinical Pharmacology, 2005 We read the recent paper by Saito et al.[1] with interest. The theme of their paper was quite similar to the one we published 6 years ago [2]. However, there was one curious point in the results. Individuals with the poor metabolizer (PM) genotype of CYP2C19 lack the CYP2C19 enzyme therefore hydroxylation of lansoprazole is assumed to be mediated by ...
Takahisa Furuta +4 more
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PharmVar GeneFocus: CYP2C19 [PDF]
Clinical Pharmacology & Therapeutics, 2020 The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications.
Botton, Mariana R. +14 more
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Methodology for clinical genotyping of CYP2D6 and CYP2C19 [PDF]
Translational Psychiatry, 2021 AbstractMany antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 and CYP2C19, and guidelines for prescribers based on genetic variants exist. Although some laboratories offer such testing, there is no consensus regarding validated methodology for clinical genotyping of CYP2D6 and CYP2C19.
Beatriz Carvalho Henriques +22 more
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Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17 [PDF]
British Journal of Clinical Pharmacology, 2010 WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • CYP2C19 polymorphisms may have clinical consequences in relation to drugs extensively metabolized by the enzyme.• Recently a new variant CYP2C19*17 was discovered.• Unlike other commonly studied variant alleles, notably CYP2C19*2 and CYP2C19*3, which are defective, CYP2C19*17 is associated with enhanced ...
Li-Wan-Po, Alain +4 more
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The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping [PDF]
Pharmacogenetics and Genomics, 2014 The polymorphic hepatic enzyme CYP2C19 catalyzes the metabolism of clinically important drugs such as clopidogrel, proton-pump inhibitors, and others and clinical pharmacogenetic testing for clopidogrel is increasingly common. The CYP2C19*10 single-nucleotide polymorphism (SNP) is located 1 bp upstream the CYP2C19*2 SNP.
Nihal El Rouby +8 more
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CYP2C19 variation and citalopram response [PDF]
Pharmacogenetics and Genomics, 2011 Variations in cytochrome P450 (CYP) genes have been shown to be associated with both accelerated and delayed pharmacokinetic clearance of many psychotropic medications. Citalopram is metabolized by three CYP enzymes. CYP2C19 and CYP3A4 play a primary role in citalopram metabolism, whereas CYP2D6 plays a secondary role.The Sequenced Treatment ...
A. J. Rush +9 more
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Omeprazole‐induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype [PDF]
British Journal of Clinical Pharmacology, 2010 WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Omeprazole‐induced acute interstitial nephritis (OIAIN) is a rare adverse drug reaction. It is typically considered to be an idiosyncratic reaction affecting elderly patients. Omeprazole is a substrate for CYP2C19 and individuals who are homozygous variant for the null allele are poor metabolizers of this ...
Wing-Yee Lo +10 more
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Metabolic activation of aegeline mediated by CYP2C19
Xenobiotica, 2021 Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multiple pharmacological activities.As one component of several dietary supplements, AGL caused a series of acute and chronic liver injuries. Nevertheless, the mechanisms of AGL-induced hepatotoxicity remain unclear. This study
Wei Li +6 more
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