Results 1 to 10 of about 30,661 (187)

PharmVar GeneFocus: CYP2C19 [PDF]

Clinical Pharmacology & Therapeutics, 2020
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications.
Botton, Mariana R., Whirl-Carrillo, Michelle, Del Tredici, Andria L., Sangkuhl, Katrin, Cavallari, Larisa H., Agúndez, José A., Duconge, Jorge, Lee, Ming Ta Michael, Woodahl, Erica L., Claudio-Campos, Karla, Daly, Ann K., Klein, Teri E., Pratt, Victoria M., Scott, Stuart A., Gaedigk, Andrea   +14 more
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Economic evaluations of pharmacogenetic and pharmacogenomic screening tests : a systematic review : second update of the literature [PDF]

, 2016
Objective : Due to extended application of pharmacogenetic and pharmacogenomic screening (PGx) tests it is important to assess whether they provide good value for money. This review provides an update of the literature. Methods : A literature search was
Annemans, Lieven, Berm, Elizabeth JJ, Boersma, Cornelis, de Looff, Margot, Postma, Maarten J, van Boven, Job FM, Vegter, Stefan, Wilffert, Bob   +7 more
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Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17 [PDF]

British Journal of Clinical Pharmacology, 2010
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • CYP2C19 polymorphisms may have clinical consequences in relation to drugs extensively metabolized by the enzyme.• Recently a new variant CYP2C19*17 was discovered.• Unlike other commonly studied variant alleles, notably CYP2C19*2 and CYP2C19*3, which are defective, CYP2C19*17 is associated with enhanced ...
Li-Wan-Po, Alain, Girard, Thierry, Farndon, Peter, Cooley, Candy, Lithgow, James   +4 more
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Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution Genome evolution and evolutionary systems biology [PDF]

, 2014
© 2014 Janha et al.; licensee BioMed Central Ltd.Background: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins.
Janha, RE, Linton, KJ, Shaheen, SO, Sisay-Joof, F, Walton, RT, Worwui, A   +5 more
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The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping [PDF]

Pharmacogenetics and Genomics, 2014
The polymorphic hepatic enzyme CYP2C19 catalyzes the metabolism of clinically important drugs such as clopidogrel, proton-pump inhibitors, and others and clinical pharmacogenetic testing for clopidogrel is increasingly common. The CYP2C19*10 single-nucleotide polymorphism (SNP) is located 1 bp upstream the CYP2C19*2 SNP.
Nihal El Rouby, Joyce A. Goldstein, Julie A. Johnson, Taimour Y. Langaee, Hao Jie Zhu, Xinwen Wang, Xinwen Wang, Xinwen Wang, John S. Markowitz   +8 more
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Pharmacogenomic testing and its future in community pharmacy [PDF]

, 2020
Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core   +1 more source

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
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Methodology for clinical genotyping of CYP2D6 and CYP2C19 [PDF]

Translational Psychiatry, 2021
AbstractMany antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 and CYP2C19, and guidelines for prescribers based on genetic variants exist. Although some laboratories offer such testing, there is no consensus regarding validated methodology for clinical genotyping of CYP2D6 and CYP2C19.
Beatriz Carvalho Henriques, Avery Buchner, Xiuying Hu, Yabing Wang, Vasyl Yavorskyy, Keanna Wallace, Rachael Dong, Kristina Martens, Michael S. Carr, Bahareh Behroozi Asl, Joshua Hague, Sudhakar Sivapalan, Wolfgang Maier, Mojca Z. Dernovsek, Neven Henigsberg, Joanna Hauser, Daniel Souery, Annamaria Cattaneo, Ole Mors, Marcella Rietschel, Gerald Pfeffer, Stacey Hume, Katherine J. Aitchison   +22 more
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CYP2C19 variation and citalopram response [PDF]

Pharmacogenetics and Genomics, 2011
Variations in cytochrome P450 (CYP) genes have been shown to be associated with both accelerated and delayed pharmacokinetic clearance of many psychotropic medications. Citalopram is metabolized by three CYP enzymes. CYP2C19 and CYP3A4 play a primary role in citalopram metabolism, whereas CYP2D6 plays a secondary role.The Sequenced Treatment ...
A. J. Rush, Susanna R. Stevens, Joanna M. Biernacka, Dennis J. O'Kane, Maureen S. Drews, John L. Black, David A. Mrazek, Karen Snyder, Richard M. Weinshilboum, Julie M. Cunningham   +9 more
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Omeprazole‐induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype [PDF]

British Journal of Clinical Pharmacology, 2010
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Omeprazole‐induced acute interstitial nephritis (OIAIN) is a rare adverse drug reaction. It is typically considered to be an idiosyncratic reaction affecting elderly patients. Omeprazole is a substrate for CYP2C19 and individuals who are homozygous variant for the null allele are poor metabolizers of this ...
Wing-Yee Lo, David Voss, David Voss, Martin Searle, John B. W. Schollum, Nuala A. Helsby, Janak R. de Zoysa, Janak R. de Zoysa, Ian J. Simpson, Ian J. Simpson, Kaye E. Logan   +10 more
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