Results 41 to 50 of about 45,621 (284)

A synergic effect between CYP2C19*2, CYP2C19*3 loss-of-function and CYP2C19*17 gain-of-function alleles is associated with Clopidogrel resistance among Moroccan Acute Coronary Syndromes patients

BMC Research Notes, 2018
Objective The main objective of our study was to investigate the association of CYP2C19*2 and CYP2C19*3 loss-of-function and CYP2C19*17 gain-of-function variants of CYP2C19 gene with Clopidogrel resistance in a sample of Moroccan Acute Coronary Syndromes
Hind Hassani Idrissi, Wiam Hmimech, Nada El Khorb, Hafid Akoudad, Rachida Habbal, Sellama Nadifi   +5 more
doaj   +1 more source

Cypc19*17 Polymorphism as a Risk-factor for Nsaids-induced Ulcers [PDF]

, 2016
The new risk-factors for peptic ulcers induced by the use of nonsteroidal antiinflammatory drugs, such as polymorphism of different isoenzymes of cytochrome P450 were considered in the article.
Balabanseva, A. (Alexandra), Onischuk, L. (Lyudmyla), Tkach, S. (Serhiy)   +2 more
core   +2 more sources

Pharmacogenetics of ecstasy: CYP1A2, CYP2C19, and CYP2B6 polymorphisms moderate pharmacokinetics of MDMA in healthy subjects [PDF]

, 2017
In vitro studies showed that CYP2C19, CYP2B6, and CYP1A2 contribute to the metabolism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) to 3,4-methylenedioxyamphetamine (MDA).
Liechti, Matthias E., Meyer Zu Schwabedissen, Henriette E., Prestin, Katharina, Schmid, Yasmin, Vizeli, Patrick   +4 more
core   +1 more source

The CYP2C19*1/*2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers

Cardiology Research and Practice, 2013
Background. The CYP2C19*2 allele may be associated with a reduced antiplatelet effect for clopidogrel. Here, we assessed whether CYP2C19*2 alleles correlate with clopidogrel responsiveness following the administration of clopidogrel in healthy Malaysian ...
Yanti Nasyuhana Sani, Lim Sheau Chin, Lim Luen Hui, Nur Elyana Yazmin Mohd Redhuan Shah Edwin, Goh Teck Hwa, Victor L. Serebruany, Yuen Kah Hay   +6 more
doaj   +1 more source

Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]

, 2005
A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard.
Boyd, Denning, Dooley, Gage, Glasmacher, Hyland, Johnson, Keevil, Ozawa, Pennick, Potoski, Roffey, Stopher, Trifilio, Vogeser, Vogeser, Vogeser   +16 more
core   +1 more source

Cannabinoids in the treatment of epilepsy: current status and future prospects [PDF]

, 2020
Cannabidiol (CBD) is one of the prominent phytocannabinoids found in Cannabis sativa, differentiating from Δ9-tetrahydrocannabinol (THC) for its non-intoxicating profile and its antianxiety/antipsychotic effects.
Albini M., Cifelli P., Di Bonaventura C., Fanella M., Giallonardo A. T., Morano A., Palma E.   +6 more
core   +1 more source

Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

Clinical and Translational Science, 2022
Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants.
Line Skute Bråten, Magnus Ingelman‐Sundberg, Marin M. Jukic, Espen Molden, Marianne Kristiansen Kringen   +4 more
doaj   +1 more source

Clopidogrel Versus Ticagrelor or Prasugrel After Primary Percutaneous Coronary Intervention According to CYP2C19 Genotype

Circulation. Cardiovascular Interventions, 2021
Supplemental Digital Content is available in the text. Background: Guidelines favor ticagrelor or prasugrel over clopidogrel in patients with myocardial infarction.
Daniel M. F. Claassens, T. Bergmeijer, Gerrit J. A. Vos, R. Hermanides, A. W. van ’t Hof, P. van der Harst, E. Barbato, C. Morisco, R. M. Tjon Joe Gin, F. Asselbergs, A. Mosterd, J. Herrman, W. Dewilde, P. Janssen, J. Kelder, B. Mahmoodi, V. Deneer, J. T. ten Berg   +17 more
semanticscholar   +1 more source

CYP2C19 variation and citalopram response [PDF]

Pharmacogenetics and Genomics, 2011
Variations in cytochrome P450 (CYP) genes have been shown to be associated with both accelerated and delayed pharmacokinetic clearance of many psychotropic medications. Citalopram is metabolized by three CYP enzymes. CYP2C19 and CYP3A4 play a primary role in citalopram metabolism, whereas CYP2D6 plays a secondary role.The Sequenced Treatment ...
David A, Mrazek, Joanna M, Biernacka, Dennis J, O'Kane, John L, Black, Julie M, Cunningham, Maureen S, Drews, Karen A, Snyder, Susanna R, Stevens, Augustus John, Rush, Richard M, Weinshilboum   +9 more
openaire   +2 more sources

Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17 [PDF]

British Journal of Clinical Pharmacology, 2010
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • CYP2C19 polymorphisms may have clinical consequences in relation to drugs extensively metabolized by the enzyme.• Recently a new variant CYP2C19*17 was discovered.• Unlike other commonly studied variant alleles, notably CYP2C19*2 and CYP2C19*3, which are defective, CYP2C19*17 is associated with enhanced ...
Li-Wan-Po, Alain, Girard, Thierry, Farndon, Peter, Cooley, Candy, Lithgow, James   +4 more
openaire   +3 more sources