Results 51 to 60 of about 45,621 (284)
Self-Reported Pharmacogenetic Medication Use in the Our Future Health Cohort. [PDF]
Clin Transl SciABSTRACT The aim of this study was to describe self‐reported use of medications with established pharmacogenetic guidance in the Our Future Health (OFH) cohort. We examined four key pharmacogenes—CYP2C19, CYP2C9, CYP2D6, and SLCO1B1—and medications supported by strong evidence for clinical actionability according to the Clinical Pharmacogenetics ...
Dixon P +4 more
europepmc +2 more sources
In vivo metabolism of ibuprofen in growing conventional pigs : a pharmacokinetic approach [PDF]
, 2019 The juvenile conventional pig has been suggested as a preclinical animal model to evaluate pharmacokinetic (PK), pharmacodynamic (PD), and safety parameters in children. However, a lot of developmental changes in pig physiology still need to be unraveled.
Croubels, Siska +3 more
core +1 more source
Reviews in Cardiovascular Medicine, 2023 Percutaneous coronary intervention (PCI) is a widely used reperfusion strategy for coronary artery disease, with millions of procedures performed annually.
Junyan Zhang, Zhongxiu Chen, Yong He
doaj +1 more source
The Pharmacogenetics of Cytochrome P450 2C19 Enzymes - Effects on Clopidogrel and Proton Pump Inhibitors [PDF]
, 2014 BACKGROUND: Cytochrome P450 (CYP) enzymes play important roles in human, including drug metabolism. CYP2 is the largest family of human CYP, with its sequence comprising almost one third of all CYP sequences, and responsible for the metabolism of ...
Muliaty, D. (Dewi) +1 more
core +4 more sources
Development of a Semi-Quantitative Assay to Detect Full-Length CYP2C19 RNA
BioTechniques, 2000 Cytochrome P450 2C19 (CYP2C19) is the enzyme responsible for the metabolism of a number of drugs, including anticonvulsants and antidepressants. We have developed a semi-quantitative competitive RTPCR assay to estimate the degree of expression of the ...
Xiao-Yan Wang +2 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2023 Aim. Study of the association of polymorphic variants of CYP2C19 (G681A), P2RY12 (H1/H2), ITGB3 (T1565C), ITGA2 (C807T), eNOS3 (T786C) genes with high residual platelet reactivity (HRPR) to clopidogrel and acetylsalicylic acid (ASA) at different terms of
T. P. Pronko +3 more
doaj +1 more source
Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle [PDF]
, 2018 peer-reviewedThe genetic mechanisms controlling residual feed intake (RFI) in beef cattle are still largely unknown. Here we performed whole transcriptome analyses to identify differentially expressed (DE) genes and their functional roles in liver ...
Fitzsimmons, Carolyn +6 more
core +3 more sources
BMC Medical Genetics, 2011 Background Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment.
Mill José G +8 more
doaj +1 more source
Pharmacogenomic Calling From Whole-Exome Sequencing in the Taiwanese Population-A Real-World Experience. [PDF]
Mol Genet Genomic MedThis study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Lin HH +9 more
europepmc +2 more sources
The Prevalence of CYP2C19 Polymorphism in Patients with Symptomatic Intracranial Atherosclerosis
Cerebrovascular Diseases ExtraIntroduction: Clopidogrel and aspirin were proved to have benefit in symptomatic intracranial stenosis. CYP2C19 polymorphism (CYP2C19*1, CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles) affects efficacy of clopidogrel.
Songchai Kittipanprayoon +4 more
doaj +1 more source