Results 51 to 60 of about 40,704 (273)
Pharmacogenetics of ecstasy: CYP1A2, CYP2C19, and CYP2B6 polymorphisms moderate pharmacokinetics of MDMA in healthy subjects [PDF]
, 2017 In vitro studies showed that CYP2C19, CYP2B6, and CYP1A2 contribute to the metabolism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) to 3,4-methylenedioxyamphetamine (MDA).
Liechti, Matthias E. +4 more
core +1 more source
Clinical pharmacology and therapy, 2020 Genotyping for CYP2C19 no function alleles to guide antiplatelet therapy after percutaneous coronary intervention (PCI) improves clinical outcomes. Although results for the increased function CYP2C19*17 allele are also reported, its clinical relevance in
Craig R. Lee +23 more
semanticscholar +1 more source
Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. [PDF]
, 2013 Profenofos is a direct acting phosphorothioate organophosphorus (OP) pesticide capable of inhibiting β-esterases such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase.
Chi, Lai-Har +8 more
core +1 more source
Sertraline and Phenytoin Drug Interaction in a Geriatric Patient [PDF]
, 2017 This report presents the case of a 78-year-old man residing in a nursing home who presented with a 2-month history of increasing lethargy and confusion. These symptoms coincided with the initiation of sertraline in the patient.
Caprio, Thomas V. +4 more
core +2 more sources
Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine
Expert Opinion on Drug Metabolism & Toxicology, 2018 Introduction: Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related disorders. Despite the overall effectiveness and safety profile of PPIs, some patients do not respond adequately or develop treatment related adverse events. This
Nihal El Rouby +2 more
semanticscholar +1 more source
Methadone and Corrected QT Prolongation in Pain and Palliative Care Patients: A Case–Control Study [PDF]
, 2017 Background: Methadone (ME) is commonly used in pain and palliative care (PPC) patients with refractory pain or intolerable opioid adverse effects (AEs).
Brown, Jack +3 more
core +2 more sources
Acta Chimica Slovenica, 2016 Extraadrenal enzymes such as CYP2C19 may participate in residual 21-hydroxylation of progesterone leading to milder phenotypes of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD). Among 94 21OHD patients 28 were homozygous or
Urh Grošelj +5 more
doaj +1 more source
Tailored Thienopyridine Therapy: No Urgency for CYP2C19 Genotyping [PDF]
Journal of the American Heart Association, 2013 Between 20% and 50% of cardiovascular patients treated with clopidogrel, an anti-P2Y12 drug, display high on-treatment platelet reactivity (HTPR) and are not adequately protected from major adverse cardiovascular events (MACE). Despite a minor influence of the CYP2C19*2 genetic variant on the pharmacodynamic response to clopidogrel (5% to 12%) and a ...
P. Fontana +3 more
openaire +3 more sources
Hematology, 2022 Background: The CYP2C19 gene is highly polymorphic, and CYP2C19 is involved in the broad interindividual variability of the clinical efficacy of certain clinical medications, such as clopidogrel.
Xiao-wen Yuan +4 more
doaj +1 more source
Endogenous Fibrinolysis : An Important Mediator of Thrombus Formation and Cardiovascular Risk [PDF]
, 2015 © 2015 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION. PUBLISHED BY ELSEVIER INC.Most acute cardiovascular events are attributable to arterial thrombosis.
Gorog, Diana A, Okafor, Osita N
core +1 more source