Results 61 to 70 of about 40,704 (273)
BMC Cardiovascular Disorders, 2023 Background Genetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with hypertension in Hakka population.
Nan Cai +8 more
doaj +1 more source
Development of a Semi-Quantitative Assay to Detect Full-Length CYP2C19 RNA
BioTechniques, 2000 Cytochrome P450 2C19 (CYP2C19) is the enzyme responsible for the metabolism of a number of drugs, including anticonvulsants and antidepressants. We have developed a semi-quantitative competitive RTPCR assay to estimate the degree of expression of the ...
Xiao-Yan Wang +2 more
doaj +1 more source
Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]
, 2005 A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard.
Boyd +16 more
core +1 more source
Cannabinoids in the treatment of epilepsy: current status and future prospects [PDF]
, 2020 Cannabidiol (CBD) is one of the prominent phytocannabinoids found in Cannabis sativa, differentiating from Δ9-tetrahydrocannabinol (THC) for its non-intoxicating profile and its antianxiety/antipsychotic effects.
Albini M. +6 more
core +1 more source
Warfarin Enantiomers Pharmacokinetics by CYP2C19 [PDF]
, 2012 Warfarin, a coumarin vitamin K antagonist, is the most widely prescribed anticoagulant agent for the control and prevention of atrial fibrillation-related thrombus formation, stroke, and arterial and venous thrombembolism (Hirsh J et al., 1998). The recommend warfarin therapy consists of the lowest dose required to maintain the target international ...
Tsukasa Uno, Yumiko Akamine
openaire +3 more sources
BMC Medical Genetics, 2011 Background Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment.
Mill José G +8 more
doaj +1 more source
Clinical and Translational Science, 2022 Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants.
Line Skute Bråten +4 more
doaj +1 more source
Scientia Pharmaceutica, 2023 CYP2C19 is a highly polymorphic gene responsible for the metabolism of commonly used drugs. CYP2C19*1, the wild-type allele, is associated with normal enzyme activity, whereas CYP2C19*2 and CYP2C19*17 lead to null and increased enzyme activity ...
Alba Alonso Llorente +6 more
doaj +1 more source
Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells. [PDF]
PLoS ONE, 2016 Cytochrome P450 2C19 (CYP2C19) is an important drug-metabolizing enzyme (DME), which is responsible for the biotransformation of several kinds of drugs such as proton pump inhibitors, platelet aggregation inhibitors and antidepressants.
Hong Sun +8 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Cannabidiol (CBD) has numerous therapeutic properties, and is used to treat neurological conditions, such as neuroinflammation. However, the optimal dose of CBD to penetrate the brain requires further investigation. The primary aim of this study was to use a mouse model and the intrabuccal route for CBD administration to determine the optimal dose at ...
Oluwadara Pelumi Omotayo +4 more
wiley +1 more source