Results 61 to 70 of about 36,503 (286)

UPLC‐ESI‐QTOF‐MS/MS Profiling, Antioxidant, and Cytotoxicity Potentials of Marrubium vulgare L. Extracts: Experimental Analysis and Computational Validation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Plant extracts are emerging as valuable options for food additives and therapeutic treatments. This study evaluated the phytochemical profile, antioxidant activity, and cytotoxicity of aerial parts of Marrubium vulgare L. crude extract (MVCE) and its subfractions.
Ines El Mannoubi, Nuha M. Alghamdi, Seham H. Bashir, Suada Alsaied Mohamed, Hedia Chaabane, Ashraf N. Abdalla, Majdi Abid, Adel Kadri, Mozaniel Santana de Oliveira   +8 more
wiley   +1 more source

Clinical Significance of Cytochrome P4502C19 (681G/A) Gene Polymorphism in Residents of the Trans-Baikal Territory in Treatment of Acid-Dependent Diseases

Архивъ внутренней медицины, 2022
Aims. To study the CYP2C19(681A/G) polymorphism among the population of the Trans-Baikal Territory in comparison with data in other regions of Russia and the world. Materials and methods. The study involved 132 people (81 women and 53 men).
A. A. Zhilina, N. V. Lareva, E. V. Luzina, S. M. Tsvinger, E. I. Morozova   +4 more
doaj   +1 more source

Clinical applications of pharmacogenomics [PDF]

, 2017
Indexación: Scopus.Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution ...
Cayún, J.P., Escalante, P., Gallegos, B., Lares-Asseff, I., Meneses, F., Miranda, C., Quiñones, L., Roco, Á., Varela, N., Zaruma-Torres, F.   +9 more
core   +1 more source

Flavonoid Profile, Biological Potentials, and In Silico Approaches of Methanol Extracts on AChE: Amaranthus retroflexus L.

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study investigated the flavonoid compounds and their biological activities in methanol extracts obtained from root, stem, leaf, and flower parts of Amaranthus retroflexus L. Flavonoids in the extracts were characterized for the first time by liquid chromatography–highresolution mass spectrometry (LC–HRMS), and a total of eight flavonoid ...
Bedrettin Selvi, Güler Durmuş, Mustafa Ceylan, Şuheda Yıldırım, Ümit M. Koçyiğit, Ümit Yırtıcı, Volkan Eyüpoğlu   +6 more
wiley   +1 more source

CYP2C19 polymorphism increases the risk of endometriosis [PDF]

Journal of Assisted Reproduction and Genetics, 2014
Estrogen metabolizing gene mutations can be associated with defective hormonal signaling leading to disease processes. Endometriosis is an estrogen dependent that can be influenced by defective signaling in the estrogen pathway.To evaluate the association of A/G 85952 CYP2C19 and A/G 937 HSD17B1 gene polymorphisms with endometriosis through the ...
Aline Amaro, Bianca Bianco, Amanda Sonnewend, Fernanda Abani Mafra, Denise Maria Christofolini, Caio Parente Barbosa   +5 more
openaire   +3 more sources

Pharmacogenetic Expression of CYP2C19 in a Pediatric Population

Journal of Personalized Medicine, 2022
Genetic variability in CYP2C19 may be associated with both lack of efficacy and toxicity of drugs due to its different metabolic status based on the presence of particular alleles. This literature review summarizes current knowledge relative to the association or treatment adaptation based on CYP2C19 genetics in a pediatric population receiving drugs ...
Marie Josette Déborah Pierre-François, Vincent Gagné, Ivan Brukner, Maja Krajinovic   +3 more
openaire   +2 more sources

Discovery of a Phenylalanine‐Derived Natural Compound as a Potential Dual Inhibitor of MDM2 and MDMX

ChemMedChem, EarlyView.
P5, a novel phenylalanine‐derived compound isolated from Micromonospora sp. MS‐62, exhibits dual inhibition of MDM2 and MDMX. Molecular docking and SPR confirm its nanomolar affinity and sustained binding kinetics. In silico profiling reveals high GI absorption, BBB permeability, and drug‐likeness, highlighting its potential as a lead for p53‐targeted ...
Ja Young Cho, Sanghwa Park, Taejung Kim, Junghye Eom, Jung‐Rae Rho, Hyoung‐Woo Bai   +5 more
wiley   +1 more source

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention [PDF]

, 2018
OBJECTIVES: This multicenter pragmatic investigation assessed outcomes following clinical implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention (PCI).
Alestock, Tameka D., Alsip, Jorge, Anderson, R. David, Ardati, Amer K., Beitelshees, Amber L., Brott, Brigitta C., Brown, Lawrence, Cavallari, Larisa H., Chumnumwat, Supatat, Clare-Salzler, Michael J., Coons, James C., Cooper-DeHoff, Rhonda M., Dave, Chintan V., Denny, Joshua C., Dillon, Chrisly, Duarte, Julio D., Elsey, Amanda R., Empey, Philip E., Gong, Yan, Hamadeh, Issam, Harada, Shuko, Hillegass, William B., Hines, Lindsay, Horenstein, Richard B., Howell, Lucius A., Jeng, Linda J.B., Johnson, Julie A., Kelemen, Mark D., Kimmel, Stephen E., Kreutz, Rolf P., Lee, Craig R., Lee, Y.M., Limdi, Nita A., Magvanjav, Oyunbileg, McDonough, Caitrin W., Montasser, May, Nelson, David R., Nutescu, Edith A., Nwaba, Devon C., Pakyz, Ruth E., Palmer, Kathleen, Peterson, Josh F., Pollin, Toni I., Pratt, Victoria M., Quinn, Alison H., Robinson, Shawn W., Schub, Jamie, Shuldiner, Alan R., Skaar, Todd C., Smith, Donald M., Sriramoju, Vindhya B., Starostik, Petr, Stevenson, James M., Stouffer, George A., Stys, Tomasz P., Varunok, Nicholas, Vesely, Mark R., Voora, Deepak, Wake, Dyson T., Weck, Karen E., Weitzel, Kristin W., Wilke, Russell A., Willig, James, Winterstein, Almut G., Zhao, Richard Y.   +64 more
core   +1 more source

Taste Profile and Relative Bioavailability of Tovorafenib Powder for Oral Suspension and Food Effect of the Tovorafenib Tablet in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A pediatric‐friendly powder for oral suspension (PfOS) of tovorafenib, a type II RAF inhibitor, was developed for patients with difficulty swallowing tablets. This open‐label, randomized, phase 1 study (QSC205140) evaluated the taste/palatability of PfOS formulations (n = 12), the relative bioavailability of the PfOS versus tablet formulation,
Yang Zhang, Mike Preigh, Jing Wang, Eleni Venetsanakos, Yujin Wang, Elly Barry, Don Corson   +6 more
wiley   +1 more source

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]

, 2016
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R., Glass, S., He, Y.J., Hoskins, J.M., McLeod, H.L., Motsinger-Reif, A., Paul, J., Winham, S.J.   +7 more
core   +1 more source