Results 81 to 90 of about 28,620 (235)

Comparación de los genotipos CYP2C19 entre caucásico español y mestizo colombiano [PDF]

, 2006
Algunos alelos del gen CYP2C19 producen enzima con actividad catalítica defectuosa, pero este gen no ha sido caracterizado en mestizo suramericano ni en caucásico español. Nos propusimos determinar la prevalencia y comparar los alelos CYP2C19*1 (nativo),
Henao, Julieta, Isaza, Carlos, Porras, Gloria   +2 more
core   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

CYP2C19 polymorphisms in the Thai population and the clinical response to clopidogrel in patients with atherothrombotic-risk factors

, 2013
Chonlaphat Sukasem,1 Ramaimon Tunthong,2 Montri Chamnanphon,1 Siwalee Santon,1 Thawinee Jantararoungtong,1 Napatrupron Koomdee,1 Santirhat Prommas,1 Apichaya Puangpetch,1 Prin Vathesatogkit21Division of Pharmacogenetics and Personalized Medicine ...
Tunthong R, Puangpetch A, Koomdee N, Sukasem C, Chamnanphon M, Prommas S, Jantararoungtong T, Vathesatogkit P, Santon S   +8 more
core  

CYP2C19 Haplotype Translator

, 2021
The translator included here was developed in the Aitchison lab to identify common haplotypes of the CYP2C19 gene, including: CYP2C19*2-*10, and *17.
Vasyl Yavorskyy (11600269), Katherine Aitchison (11598011)   +1 more
core   +1 more source

A novel AllGlo probe-quantitative PCR method for detecting single nucleotide polymorphism in CYP2C19 to evaluate the antiplatelet activity of clopidogrel

Scientific Reports
CYP2C19 gene has multiple single nucleotide polymorphism (SNP), which is the major determinant for clopidogrel treatment responses. Therefore, CYP2C19 SNP detection is essential for predicting clopidogrel efficacy.
Hongwei Li, Yizhen Fang, Yongquan Chen, Yuning Lin, Zanxi Fang, Zhiyuan Lin, Huabin Xie, Zhongying Zhang   +7 more
doaj   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source

CYP2C19 Polymorphism in Childhood Hematological Malignancy [PDF]

, 2006
Cytochrome P450 2C19 (CYP2C19) participates in the metabolism of many clinically important drugs and many xenobiotic compounds. Genetic polymorphisms of the CYP2C19 gene are described to have possible effect on drug treatment and increasing ...
Abu_eid, Sameer Ibrahim
core  

Screening for CYP2C19 Gene variants in a healthy Jordanian population [PDF]

, 2017
Purpose: To genotype healthy Jordanian population from three different provinces (Amman, Zarqa and Irbid) for cytochrome P4502C19 and to identify the allelic distribution of CYP2C19 variants in comparison with other findings around the world.Methods ...
Al-Khateeb, Rema, Al-Emerieen, Ala'a, Abdellatif, Reem, Yasin, Salem, Al-Khateeb, Hakam, Al-Hadidi, Al-Hakam, Al-Mazaydeh, Zainab, Tahtamouni, Lubna   +7 more
core   +1 more source

Functional characterization of two novel CYP2C19 variants (CYP2C19*18andCYP2C19*19) found in a Japanese population

Xenobiotica, 2007
Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism of a wide range of therapeutic drugs and exhibits genetic polymorphism with interindividual differences in metabolic activity. We have previously described two CYP2C19 allelic variants, namely CYP2C19*18 and CYP2C19*19 with Arg329His/Ile331Val and Ser51Gly/Ile331Val substitutions,
N. Hanioka, N. Hanioka, Y. Tsuneto, Y. Saito, T. Sumada, K. Maekawa, K. Saito, J. Sawada, S. Narimatsu   +8 more
openaire   +2 more sources

The TOP‐GERD Trial: Comparative Efficacy of Tegoprazan Versus Pantoprazole in the Treatment of Erosive Oesophagitis in a Non‐Asian Population

Alimentary Pharmacology &Therapeutics, EarlyView.
In this randomized, double‐blind trial in Mexican adults with erosive oesophagitis, tegoprazan did not significantly improve the primary 4‐week ITT healing endpoint versus pantoprazole (88.9% vs. 79.4%; p = 0.33), but produced faster symptom improvement. Encouraging per‐protocol and severe‐oesophagitis findings warrant confirmation.
José M. Remes‐Troche, Luis Raúl Valdovinos‐García, C. Prakash Gyawali, José Luis Vargas‐Basurto, Carlos Alberto Reyes‐Medina, Gisselle Vanessa González‐Hernández, A. Rafael Bernal Mendez, H. H. Barragán Cordova, Pablo Thomas‐Dupont, Peter Grube‐Pagola   +9 more
wiley   +1 more source