Results 91 to 100 of about 28,620 (235)

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

Both CYP2C19 and PON1 Q192R Genotypes Influence Platelet Response to Clopidogrel by Thrombelastography in Patients with Acute Coronary Syndrome

Cardiovascular Therapeutics, 2019
Objective. The objective of this study is to explore the relationships of the effects of CYP2C19 and PON1 Q192R polymorphism on the activity of clopidogrel and the risk of high platelet responsiveness (HPR) by thrombelastography in patients with acute ...
Wenxing Peng, Xiujin Shi, Xiaoyu Xu, Yang Lin   +3 more
doaj   +1 more source

Integrating Pharmacogenomic Testing Within the 4Ms Framework for Management of Behavioral Symptoms in Advanced Vascular Dementia: A Case Study

Journal of the American Geriatrics Society, EarlyView.
Pharmacogenomic‐guided managment of behavioral symptoms within the 4Ms framework.
Gianna Franco, Collins Njoku, Mary L. Wagner, Fred A. Kobylarz   +3 more
wiley   +1 more source

Study of CYP2C19 gene polymorphisms in children with pharmacoresistant epilepsy

, 2019
Проведено фармакогенетичне дослідження 83 дітей з фармакорезистентною епілепсією віком від 11 місяців до 18 років. За допомогою алель-специфічної полімеразної ланцюгової реакції (ПЛР) визначено поліморфізм гена CYP2C19 (CYP2C19*1 CYP2C19*2).
Танцура, Євген Олександрович, Третьяков, Дмитро Володимирович, Танцура, Людмила Миколаївна, Пилипець, Олена Юріївна   +3 more
core   +1 more source

Pharmacokinetics of Buccally Administered Cannabidiol and Oral Carprofen During Single‐ and Repeated‐Dose Administration in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Cannabidiol (CBD) is increasingly used as an adjunct treatment for chronic pain in dogs, but information on repeated‐dose pharmacokinetics and potential interactions with commonly used analgesics remains limited. This study evaluated the pharmacokinetics of buccally administered CBD, its major metabolites, and orally administered carprofen in ...
Tilen Vake, Katerina Tomsič, Žiga Žgank, Mihaela Klasić, Janja Babič, Zlatka Bajc, Jožica Dolenc, Gabrijela Tavčar Kalcher, Odon Planinšek, Tomaž Snoj   +9 more
wiley   +1 more source

Pharmacogenomics in Dentistry: From CYP‐Mediated Drug Response to Precision Prescribing in Oral Healthcare

Oral Diseases, EarlyView.
ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci   +3 more
wiley   +1 more source

Distribution of genotypes of CYP2C19.

, 2013
Distribution of genotypes of CYP2C19.
Yi-Tong Ma (317802), Fen Liu (317808), Ying-Ying Zheng (317805), Xiang Xie (317801), Yi-Ning Yang (317803), Xiang Ma (317806), Xiao-Mei Li (110713), Bang-Dang Chen (317807), Zhen-Yan Fu (317804)   +8 more
core   +1 more source

Role of CYP2C19 polymorphisms in patients with endometriosis

Gynecological Endocrinology, 2009
To investigate the association of CYP2C19 genotypes with endometriosis.The study included 100 women who underwent laparotomy or laparoscopy: 50 patients with endometriosis diagnosed with surgery and histopathology, and 50 control subjects who had no evidence of endometriosis during exploratory laparotomy or laparoscopy.
Filiz, Cayan, Lokman, Ayaz, Meral, Aban, Saffet, Dilek, Lülüfer Tamer, Gümüş   +4 more
openaire   +2 more sources

Impact of Letermovir on Voriconazole Concentrations in Lung Transplant Patients

Transplant Infectious Disease, EarlyView.
Concomitant letermovir was associated with lower voriconazole exposure and reduced attainment of commonly used efficacy thresholds in lung transplant recipients. Routine therapeutic drug monitoring after letermovir initiation is recommended, and empiric voriconazole dose escalation may be needed to avoid subtherapeutic exposure. ABSTRACT Background The
Leah Georgiades, Sunish Shah, Erin K. McCreary, Fernanda Silveira, Raman Venkataramanan, Vignesh Vasudevan, Ryan M. Rivosecchi   +6 more
wiley   +1 more source

The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia

, 2009
Background/aims: We aimed to determine the distribution of cytochrome P450 2C19 (CYP2C19) genotype frequencies in Turkish patients with dyspepsia. Methods: CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia.
Omer SENTURK, Altay CELEBI, Cem AYGUN, Aygun, Cem, Orhan KOCAMAN, Hakan SAVLI, Kocaman, Orhan, Konduk, Bugra Tolga, ÇELEBİ, ALTAY, Hulagu, SADETTİN, Senturk, Omer, SAVLI, HAKAN, Bugra Tolga KONDUK, Sadettin HULAGU   +13 more
core   +1 more source