Results 111 to 120 of about 27,792 (251)

Do CYP2C19 and ABCB1 gene polymorphisms and low CYP3A4 isoenzyme activity have an impact on stent implantation complications in acute coronary syndrome patients?

, 2017
Eric Rytkin,1 Karin B Mirzaev,1 Elena A Grishina,1 Valeriy V Smirnov,2 Kristina A Ryzhikova,1 Zhannet A Sozaeva,1 Michael Iu Giliarov,2 Denis A Andreev,2 Dmitriy A Sychev1 1Russian Medical Academy of Continuous Professional Education, 2I.M.
Rytkin E, Smirnov VV, Ryzhikova KA, Sychev DA, Sozaeva ZA, Grishina EA, Andreev DA, Mirzaev KB, Giliarov MI   +8 more
core  

Genomic Medicine Sweden: Advancing precision medicine at the national level

Journal of Internal Medicine, Volume 300, Issue 4, Page 397-419, October 2026.
Abstract High‐throughput sequencing has transformed clinical diagnostics of rare diseases (RD), cancer and infectious diseases by enabling the identification of disease‐causing genetic alterations and facilitating individualised treatment and care.
Anders Edsjö, Anna Lindstrand, Panagiotis Baliakas, David Gisselsson, Paula Mölling, Mia Wadelius, Åsa Johansson, Hannes Olauson, Hans Ehrencrona, Lovisa Lovmar, Christian G. Giske, Henrik Green, Ann Nordgren, Fulya Taylan, Martin Hallbeck, Erika Tång Hallbäck, Anna Green, Markus Heidenblad, Kina Höglund, Anders Jemt, Carl Mårten Lindqvist, Maria Johansson Soller, Magnus Sabel, Colum Walsh, Hartmut Vogt, Craig E. Wheelock, Martin Bergö, Jens Enoksson, Ann Ekberg Jansson, Cecilia Fagerström, Jan Holgersson, Stephanie Anja Juran, Mats G. Karlsson, Frida Lundmark, Eva Tiensuu Janson, Andreas Muranyi Scheutz, Malin Sund, Päivi Östling, Sofia Gruvberger‐Saal, Marene Landström, Malin Melin, Lars Palmqvist, Richard Palmqvist, Bianca Stenmark, Anna Wedell, Malin Karnå, Katarina Nyström, Tobias Strid, Per Sikora, Maria Johansson, Therese Fagerqvist, Mirja Carlsson Möller, Oskar Frisell, Mats Ulfendahl, Mikaela Friedman, Lucia Cavelier, Valtteri Wirta, Thoas Fioretos, Richard Rosenquist   +58 more
wiley   +1 more source

CYP2C19 polymorphisms in drug metabolism and response

, 2014
Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. Of the many
Ming Chang (18637489)
core   +1 more source

CYP2C19 Polymorphism in Childhood Hematological Malignancy [PDF]

, 2006
Cytochrome P450 2C19 (CYP2C19) participates in the metabolism of many clinically important drugs and many xenobiotic compounds. Genetic polymorphisms of the CYP2C19 gene are described to have possible effect on drug treatment and increasing ...
Abu_eid, Sameer Ibrahim
core  

N‐(1H‐Indazolyl) Aryl Sulfonamide Hybrids as Potential Dihydropteroate Synthase Inhibitors: In Vitro Antibacterial Activity Against Escherichia coli and Staphylococcus aureus and Computational Modeling

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Sixteen indazole–sulfonamide hybrids exhibit species‐dependent antibacterial activity against E. coli and S. aureus, with the lead compound displaying an eightfold lower MIC than sulfathiazole against E. coli. Molecular docking against wild‐type and Sul1‐resistant dihydropteroate synthase identifies a candidate retaining binding affinity toward the ...
Romaisaa Boudza, Ferdaous Elandaloussi, Khalid Boujdi, Jaume Segura‐Garcia, Nabil El Brahmi, Saïd El Kazzouli, Ismaïl Moukadiri, Sergi Maicas, Salim Bounou   +8 more
wiley   +1 more source

Study of CYP2C19 gene polymorphisms in children with pharmacoresistant epilepsy

, 2019
Проведено фармакогенетичне дослідження 83 дітей з фармакорезистентною епілепсією віком від 11 місяців до 18 років. За допомогою алель-специфічної полімеразної ланцюгової реакції (ПЛР) визначено поліморфізм гена CYP2C19 (CYP2C19*1 CYP2C19*2).
Танцура, Євген Олександрович, Третьяков, Дмитро Володимирович, Танцура, Людмила Миколаївна, Пилипець, Олена Юріївна   +3 more
core   +1 more source

Investigation of In Vitro α‐Amylase Inhibitory, Antioxidant, Phytochemical Profiling, Molecular Docking, and Swiss ADME Analysis of Magnolia zotictla

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Phytochemical profiling was determined via HPLC and GC–MS analysis. In HPLC analysis, five compounds were identified, while five compounds were identified through GC–MS. The plant extract exhibited good antioxidant efficacy in the DPPH assay, highlighting its capacity to neutralize free radicals. The extract has IC5₀ value of 123.8 µg/mL, while that of
Muhammad Zahoor, Usra Shah, Marwa Bibi, Adnan Khan, Haseena, Amal Alotaibi   +5 more
wiley   +1 more source

GC–MS‐Based Phytochemical Profiling and Integrated Evaluation of Antioxidant, Antibacterial, and In Silico Studies of Kumaun Himalayan Strobilanthes Species

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Himalayan Strobilanthes species: phytochemical profiling, bioactivities, and In silico Studies. ABSTRACT Five Strobilanthes species indigenous to the Kumaun Himalayan region of Uttarakhand, India, have been historically employed in traditional medicine to treat bacterial infections, inflammatory conditions, and respiratory ailments, but remain largely ...
Sakshi Negi, Ravendra Kumar, Vaishnavi Rawat, Pooja Bargali, Aashish Kumar Sagar, Stefania Garzoli, Riddhiman Lahiri, Shilpi Rawat, Avdhesh Kumar, Manmohan Singh Rawat, Jolanta Maslowiecka, Valery A. Isidorov, Dharmendra S. Rawat   +12 more
wiley   +1 more source

Distribution of genotypes of CYP2C19.

, 2013
Distribution of genotypes of CYP2C19.
Yi-Tong Ma (317802), Fen Liu (317808), Ying-Ying Zheng (317805), Xiang Xie (317801), Yi-Ning Yang (317803), Xiang Ma (317806), Xiao-Mei Li (110713), Bang-Dang Chen (317807), Zhen-Yan Fu (317804)   +8 more
core   +1 more source

CYP2C19 Loss-of-Function is an Associated Risk Factor for Premature Coronary Artery Disease: A Case–Control Study

Wenhao Chen,1 Yuanliang Liu,2 Xunwei Deng,3 Bin Li,1 Hao Wang,1 Guoliang Wei,1 Kehui Chen,1 Shen Wang1 1Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 2Department of Computer Tomography, Meizhou People’
Liu Y, Chen K, Wang S, Chen W, Li B, Wang H, Wei G, Deng X   +7 more
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