Results 121 to 130 of about 28,620 (235)

Antimicrobial Activity and In Silico ADME Properties of Tyrosol and Their Derivatives Compounds

ChemistrySelect, Volume 11, Issue 41, 3 November 2026.
In the present study, tyrosol derivatives were obtained with the aim of improving their antimicrobial activity. Derivative 2 exhibited good antimicrobial activity, with an MIC of 3.9 µg/mL. Derivative 3, meanwhile, showed moderate activity and is novel in the literature. ABSTRACT According to the World Health Organization (WHO), bacterial resistance is
Kathia Raquel Murillo Padilla, Rayanne Priscila Vieira da Conceição, José Edson de Sousa Siqueira, Luana Cardoso de Oliveira, Mayra Suelen da Silva Pinheiro, Patrícia Santana Barbosa Marinho, Andrey Moacir do Rosario Marinho   +6 more
wiley   +1 more source

The non-linear and linear effects of CYP2C19 metaboliser status on DNA methylation: a methylome-wide association study

Clinical Epigenetics
Background CYP2C19 metabolises many medications. Its enzymatic activity can be inferred from genetic variants within CYP2C19 that link to the efficacy of drug treatments and their side effects.
Chen Shen, Mark J. Adams, Eleanor Davyson, Matthew H. Iveson, Simon R. Cox, Sarah E. Harris, Andrew M. McIntosh, Xueyi Shen   +7 more
doaj   +1 more source

CYP2C19*2 Polymorphism Is Associated with Impaired Oral Clearance of Gliclazide in Healthy Chinese

Pharmacogenomics and Personalized Medicine, 2020
Elaine Chow,1,2 Emily WM Poon,2 Benny SP Fok,1 Juliana CN Chan,2 Brian Tomlinson1–3 1Phase 1 Clinical Trial Centre, The Chinese University of Hong Kong, Hong Kong; 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong ...
Chow E, Poon EWM, Fok BSP, Chan JCN, Tomlinson B   +4 more
doaj  

Phase 1 Study of Safety and PK With A Combination of Omeprazole and Trimetazidine for Fatty Acid Oxidation Inhibition in Patients With Advanced Solid Tumors

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Fatty acid oxidation (FAO) is a metabolic vulnerability in cancer cells, making pharmacologic FAO inhibition a promising therapeutic strategy. This Phase I, open‐label, 3 + 3 dose‐escalation study evaluated the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of two oral FAO inhibitors—omeprazole (KN510), a carnitine ...
Wonyoung Choi, Jung W. Chun, Sung H. Sim, Sung‐Sik Han, Woo J. Lee, Joon H. Kang, Hyun Chul Kim, SeungHwan Lee, Jun H. Lee, Hyun J. Yoo, Soo‐Youl Kim, Sang M. Woo   +11 more
wiley   +1 more source

Defining Core Functions and Forms for the Implementation of Pharmacogenomics Testing in Primary Care

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Pharmacogenomics (PGx), utilizing a patient's DNA to individualize medication prescribing, minimizes adverse events and improves patient outcomes. However, the integration of PGx into primary care remains sparse. PGx testing encompasses multiple components and can be considered a complex health intervention.
Sanjana Ramesh, Larisa H. Cavallari, Victoria Wittner, Josiah Allen, Mari Angelica S. Cayabyab, Emily J. Cicali, Nihal El Rouby, Shayna R. Killam, Nita Limdi, Mohamed Nagy, Natasha Petry, April Schultz, D. Max Smith, Evangelia Eirini Tsermpini, Ron H. N. van Schaik, Ramzi G. Salloum, Sony Tuteja   +16 more
wiley   +1 more source

CYP2C19 polymorphisms in drug metabolism and response

, 2014
Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. Of the many
Ming Chang (18637489)
core  

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

CYP2C19 polymorphism frequency in Russian patients in Central Russia and Siberia with acute coronary syndrome

, 2017
Karin B Mirzaev,1 Elena M Zelenskaya,2 Olga L Barbarash,3 Vladimir I Ganyukov,3 Konstantin A Apartsin,4,5 Natalya O Saraeva,4 Konstantin Y Nikolaev,6,7 Kristina A Ryzhikova,1 Galina I Lifshits,2,5,7 Dmitry A Sychev1 1Russian Medical Academy of Continuous
Zelenskaya EM, Apartsin KA, Ryzhikova KA, Lifshits GI, Sychev DA, Ganyukov VI, Barbarash OL, Mirzaev KB, Saraeva NO, Nikolaev KY   +9 more
core  

CYP2C19 Substrate [PDF]

, 2020
openaire   +1 more source

Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
We designed, synthesised, and evaluated new guanidine derivatives as potential covalent inhibitors of TMPRSS2, a key protease for SARS‐CoV‐2 entry. Computational studies showed that some compounds have improved binding over nafamostat. However, experimentally none effectively blocked viral entry in cell assays, indicating further optimisation is needed.
Marco Minneci, Barbara Farkaš, Adeyemi Rahman, Inga Nehlmeier, Amy Eichmann, Stefan Pöhlmann, Isabel Rozas   +6 more
wiley   +1 more source