Results 121 to 130 of about 27,792 (251)

The Roles of EETs in Neurological Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang, Mengya Li, Banglian Hu, Guoqiang Fei, Honghua Zheng, Xin Wang, Jing Ding   +6 more
wiley   +1 more source

The non-linear and linear effects of CYP2C19 metaboliser status on DNA methylation: a methylome-wide association study

Clinical Epigenetics
Background CYP2C19 metabolises many medications. Its enzymatic activity can be inferred from genetic variants within CYP2C19 that link to the efficacy of drug treatments and their side effects.
Chen Shen, Mark J. Adams, Eleanor Davyson, Matthew H. Iveson, Simon R. Cox, Sarah E. Harris, Andrew M. McIntosh, Xueyi Shen   +7 more
doaj   +1 more source

CYP2C19*2 Polymorphism Is Associated with Impaired Oral Clearance of Gliclazide in Healthy Chinese

Pharmacogenomics and Personalized Medicine, 2020
Elaine Chow,1,2 Emily WM Poon,2 Benny SP Fok,1 Juliana CN Chan,2 Brian Tomlinson1–3 1Phase 1 Clinical Trial Centre, The Chinese University of Hong Kong, Hong Kong; 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong ...
Chow E, Poon EWM, Fok BSP, Chan JCN, Tomlinson B   +4 more
doaj  

CYP2C19 Poor Metabolizer Status and High System Inflammation Response Index are Independent Risk Factors for Premature Myocardial Infarction: A Hospital-Based Retrospective Study [PDF]

Wendao Han, Nating Xiong, Renkai Zhong, Zhongyi Pan Department of Blood Transfusion, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Wendao Han, Department of Blood Transfusion, Meizhou ...
Pan Z, Zhong R, Xiong N, Han W
core  

CYP2C19 genetic polymorphisms in Maltese patients on clopidogrel therapy [PDF]

, 2019
Introduction and Aims: The prevalence of CYP2C19 genetic polymorphisms in the Maltese population is not reported. The aims were to determine CYP2C19 *2 and *17 allele frequencies and CYP2C19 genotype distribution in a cohort of Maltese patients on ...
Wirth, Francesca, Zahra, Graziella, Xuereb, Robert G., Barbara, Christopher H., Azzopardi, Lilian M., Camilleri, Liberato, Fenech, Albert   +6 more
core  

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 731-744, September 2026.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source

Prevalence of CYP2C19 Variants in Patients with Cardiovascular Disease from the Yunnan-Guizhou Plateau in Southwestern China [PDF]

Xiu-Ping Li,1,* Jun-Ling Wang,1,* San-Xi Lei,2 Bo-Yu Chen,2 Xiang Ma,2 Fei He,3 Chao-Fu Yue,4 Hong-Xia Liu,1 Jian-Peng Hu,1 Qian Xiong,1 Ting Ji,1 Zheng-Fu Zhang,5 Yong Sun,6 Hong-Wei Li1 1Department of Clinical Laboratory, Kunming ...
He F, Li XP, Yue CF, Ma X, Xiong Q, Sun Y, Li HW, Ji T, Chen BY, Liu HX, Hu JP, Zhang ZF, Lei SX, Wang JL   +13 more
core  

The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia

, 2009
Background/aims: We aimed to determine the distribution of cytochrome P450 2C19 (CYP2C19) genotype frequencies in Turkish patients with dyspepsia. Methods: CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia.
Omer SENTURK, Altay CELEBI, Cem AYGUN, Aygun, Cem, Orhan KOCAMAN, Hakan SAVLI, Kocaman, Orhan, Konduk, Bugra Tolga, ÇELEBİ, ALTAY, Hulagu, SADETTİN, Senturk, Omer, SAVLI, HAKAN, Bugra Tolga KONDUK, Sadettin HULAGU   +13 more
core   +1 more source

PPI Misuse in Bangladesh: Confronting a Silent Epidemic Through Deprescribing and Regulatory Reform—A Policy Perspective

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Proton pump inhibitors (PPIs) are subject to rampant global misuse, posing a significant public health challenge. This issue is particularly acute in low‐ and middle‐income countries like Bangladesh, where preliminary data indicate alarmingly high rates of inappropriate prescribing, driven by systemic factors within the ...
Abdullaha Al Mamun, Md Rabiul Awual, K. A. M. Inzamul Islam   +2 more
wiley   +1 more source