Results 31 to 40 of about 230,059 (269)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Role of extracellular ATP and P2 receptors in regulating cyst expansion and interstitial inflammation in polycystic kidney disease

Frontiers in Physiology, 2013
Polycystic kidney diseases (PKD) are a group of inherited ciliopathies in which the formation and growth of multiple cysts derived from the distal nephron and collecting duct leads to the disruption of normal kidney architecture, chronic interstitial ...
G eRangan
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Case Report: Surgical treatment of lumbar ligamentum flavum cysts combined with spinal instability causing radiculopathy

Frontiers in Surgery
PurposeThis study aimed to describe a case of a patient with a lumbar ligamentum flavum cyst combined with spinal instability who underwent cyst resection and transforaminal lumbar interbody fusion (TLIF).MethodsWe present a rare case of a patient with a
Keshi Yang, Keshi Yang, Changbin Ji, Changbin Ji, Dawei Luo, Dawei Luo, Jiwei Yin, Jiwei Yin, Xiaozhe Wu, Xiaozhe Wu, Hui Xu, Hui Xu   +11 more
doaj   +1 more source

Tocilizumab for the fifth progression of cystic childhood craniopharyngioma—a case report

Frontiers in Endocrinology, 2023
We present the case of a 15-year-old girl, with a fifth cystic progression of an adamantinomatous craniopharyngioma after multiple surgeries and previous local radiotherapy.
Evelien de Vos-Kerkhof, Dennis R. Buis, Maarten H. Lequin, Carlien A. Bennebroek, Eleonora Aronica, Esther Hulleman, Nitash Zwaveling-Soonawala, Hanneke M. van Santen, Antoinette Y. N. Schouten-van Meeteren   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Gaussian filter facilitated deep learning-based architecture for accurate and efficient liver tumor segmentation for radiation therapy

Frontiers in Oncology
PurposeAddressing the challenges of unclear tumor boundaries and the confusion between cysts and tumors in liver tumor segmentation, this study aims to develop an auto-segmentation method utilizing Gaussian filter with the nnUNet architecture to ...
Hongyu Lin, Min Zhao, Lingling Zhu, Xi Pei, Haotian Wu, Lian Zhang, Ying Li   +6 more
doaj   +1 more source

Study of Cystic Neck Swellings Over A Period of 5 Years [PDF]

International Journal of Anatomy Radiology and Surgery, 2015
Background and Aim: The swellings in head neck region are of great clinical significance. The pathology of swellings may vary from cysts, benign tumours and malignancy to metastatic tumours. So, these neck swellings are a great dilemma to surgeon for
Darshan Goyal
doaj   +1 more source

Dense granule protein 3 of Toxoplasma gondii plays a crucial role in the capability of the tissue cysts of the parasite to persist in the presence of anti-cyst CD8+ T cells during the chronic stage of infection

Frontiers in Immunology, 2023
Toxoplasma gondii establishes chronic infection by forming tissue cysts, and this chronic infection is one of the most common parasitic infections in humans.
Rajesh Mani, Mohamed H. Abdelaziz, Eri Ochiai, Qila Sa, Barbara A. Fox, David J. Bzik, Yasuhiro Suzuki   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source