Results 31 to 40 of about 12,769 (186)

satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect

Genome Biology, 2023
The impact of millions of individual genetic variants on molecular phenotypes in coding sequences remains unknown. Multiplexed assays of variant effect (MAVEs) are scalable methods to annotate relevant variants, but existing software lacks ...
Ian Hoskins, Song Sun, Atina Cote, Frederick P. Roth, Can Cenik   +4 more
doaj   +1 more source

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Gidijala, Loknath,, Kiel, Jan A.K.W.,, Klei, Ida J. van der,, Veenhuis, Marten,   +3 more
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Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap

Biology Open, 2015
In addition to its role in the endogenous synthesis of cysteine, cystathionine gamma-lyase (CGL) is a major physiological source of the vasorelaxant hydrogen sulfide.
Hua Jiang, K. Joseph Hurt, Kelsey Breen, Sally P. Stabler, Robert H. Allen, David J. Orlicky, Kenneth N. Maclean   +6 more
doaj   +1 more source

H2S biosynthesis and catabolism: new insights from molecular studies [PDF]

, 2017
Hydrogen sulfide (H2S) has profound biological effects within living organisms and is now increasingly being considered alongside other gaseous signalling molecules, such as nitric oxide (NO) and carbon monoxide (CO).
A Asimakopoulou, A Badiei, A Badiei, A Calderwood, A Jamroz-Wiśniewska, A Kalani, A Madurga, A Papapetropoulos, A Sun, AA Untereiner, AD Ang, AF Kamath, AF Perna, AF Perna, AK Mustafa, AL King, B Calenic, B Fox, B Gemici, B Gemici, B Geng, B Geng, B Qabazard, B Qabazard, B Szczesny, BD Paul, BJ Henriques, C Coletta, C Hine, C Hine, C Konrad, C Köhn, C Maestro de las Casas, C Steegborn, C Szabo, C Yang, CW Huang, D Liang, D Liao, DA Wing, DC Croteau-Chonka, DI Zafeiriou, DL Miller, DW Porter, DW Porter, E Albertini, E Grambow, E Lagoutte, EG Lynn, EG Mueller, EG Shesely, EM Bos, F Talaei, FL Zhao, G Chwatko, G Szabo, G Tang, G Tang, G Wang, G Yang, G Yang, G Yang, G Yang, G Yang, G Yang, G Yang, G Yang, G Yang, G Zagli, G Zhang, GA Benavides, GD Yang, GK Kolluru, GV Velmurugan, H Duplain, H Jang, H Jurkowska, H Kabil, H Li, H Shi, H Zhang, HB Roman, HG Lee, HL Jiang, HS Jin, I Baiges, I Billaut-Laden, I Hirata, I Ishii, I Meo Di, I Ueki, J Cai, J Candela, J Ereño-Orbea, J Hamelet, J Hamelet, J Wang, J Wang, JB Vicente, JD Finkelstein, JG Vande Weghe, JJ Li, JL Meng, JL Wallace, JN Mayo, JT Brosnan, JW Calvert, JW Elrod, JW Horsman, K Eto, K Kondo, K Modis, K Módis, K Módis, K Ono, K Robert, K Wang, K Wilson, K Yao, KL Flannigan, KM Syhr, KN Maclean, KR Olson, KR Olson, L Chang, L Chen, L Gambari, L Li, L Li, L Li, L Li, L Miao, L Miao, L Wang, L Wang, L Xei, LA Harker, LL Pan, M Ackermann, M Goubern, M Liang, M Libiad, M Meier, M Nuño-Ayala, M Okomoto, M Pimentel, M Watanabe, M Whiteman, M Whiteman, M Whiteman, M Whiteman, M Whiteman, M Yang, MA Guzman, MD Fonseca, MH Stipanuk, MH Stipanuk, MK Thorson, MK Thorson, MM Cortese-Krott, MM Cortese-Krott, MP Gallegos-Arreola, MR Filipovic, MR Filipovic, MR Jackson, MW Budde, MY Ali, MY Tsai, N Endo, N Nagahara, N Nagahara, N Shibuya, N Weiss, O Kabil, O Kabil, O Kabil, O Kabil, O Zayachkivska, P Manna, P Nicholls, Peter Rose, Philip K. Moore, PK Yadav, PM Mrozikiewicz, PM Snijder, PS Ganapathy, Q Hu, QH Meng, R Baskar, R Ding, R Greiner, R Kodela, R Picton, R Tocmo, R Tocmo, R Wang, R Yang, RC Zanardo, RH Abeles, RN Carter, RS Beard, S Banu, S Bhattacharyya, S Dayal, S Dayal, S Gupta, S Huang, S Jain, S Jin, S Kundu, S Mani, S Pushpakumar, S Ramasamy, S Saha, S Sen, S Shastry, S Shi, S Xu, SH Cheung, SK Jain, SR Lentz, SY Wu, T Ida, T Itou, T Ivanciuc, T Krejcova, T Takahashi, TJ Lechuga, TM Hildbrant, TT Pan, TW Miller, U Sen, U Sen, U Sen, V Tiranti, V Vitvisky, VE Laubach, W Liu, W Qiao, W Wang, W Washtien, W Zhao, W Zhu, WA Pryor, WJ Cai, X Li, X Shen, X Shen, XH Wang, XQ Tang, XQ Tang, Y Gao, Y Hagiya, Y Hu, Y Kimura, Y Kumai, Y Li, Y Liu, Y Pei, Y Shen, Y Wei, Y Xu, Y Zhou, Yi Zhun Zhu, YJ Peng, Z Guo, Z Jiang, Z Pan, Z Wang, Z Zhang, ZL Clarke, ZZ Xie, ZZ Zhao   +272 more
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1,25‐dihydroxyvitamin D 3 influences cellular homocysteine levels in murine preosteoblastic MC3T3‐E1 cells by direct regulation of cystathionine β‐synthase [PDF]

, 2011
High homocysteine (HCY) levels are a risk factor for osteoporotic fracture. Furthermore, bone quality and strength are compromised by elevated HCY owing to its negative impact on collagen maturation.
Boonen, Bouillon, Bouillon, Chiku, Daci, Eberhardt, Finkelstein, Garcion, Ge, Heaney, Herrmann, Hofbauer, Kang, Kim, Koh, Kolhouse, Kriebitzsch, Levasseur, Lips, Liu, Lubec, McLean, Meyer, Mosharov, Prudova, Raposo, Robert, Rodan, Rosen, Saito, Saposnik, Schuster, Selhub, Singh, Stipanuk, Taoka, van Guldener, van Meurs, Verlinden, Vitvitsky, Wang   +40 more
core   +3 more sources

Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Hyperhomocysteinemia is a risk factor for ischemic stroke; however, a targeted treatment strategy is lacking partly because of limited understanding of the causal role of homocysteine in cerebrovascular pathogenesis.
Sean X. Gu, Vijay K. Sonkar, Parmeshwar B. Katare, Rahul Kumar, Warren D. Kruger, Erland Arning, Teodoro Bottiglieri, Steven R. Lentz, Sanjana Dayal   +8 more
doaj   +1 more source

The Quantitative Significance of the Transsulfuration Enzymes for H2S Production in Murine Tissues [PDF]

, 2011
The enzymes of the transsulfuration pathway, cystathionine --synthase (CBS) and cystathionine --lyase (CSE), are important for the endogenous production of hydrogen sulfide (H2S), a gaseous signaling molecule. The relative contributions of CBS and CSE to
Kery V, Linden DR, Mudd SH, Omer Kabil, Peter Xie, Ruma Banerjee, Victor Vitvitsky   +6 more
core   +1 more source

Homocystinuria due to cystathionine beta synthase deficiency

Indian Journal of Dermatology, Venereology and Leprology, 2008
A two year-old male child presented with cutis marmorata congenita universalis, brittle hair, mild mental retardation, and finger spasms. Biochemical findings include increased levels of homocysteine in the blood-106.62 micromol/L (normal levels: 5.90-16 micromol/L).
Rao, T Narayana, Radhakrishna, K, Mohana, Rao TS, Guruprasad, P, Ahmed, Kamal   +4 more
openaire   +2 more sources

A continuous spectrophotometric assay for human cystathionine beta-synthase [PDF]

Analytical Biochemistry, 2005
We report a new continuous spectrophotometric assay for human cystathionine beta-synthase (hCBS). This assay relies upon the finding that hCBS will take cysteamine in place of L-homocysteine, thereby producing thialysine. Thialysine is, in turn, decarboxylated by lysine decarboxylase, releasing CO2 that is monitored by the sequential action of ...
Weijun, Shen, Molly K, McGath, Ruby, Evande, David B, Berkowitz   +3 more
openaire   +2 more sources

The Effects of Cocaine on Different Redox Forms of Cysteine and Homocysteine, and on Labile, Reduced Sulfur in the Rat Plasma Following Active versus Passive Drug Injections [PDF]

, 2013
Received: 28 November 2012 / Revised: 19 April 2013 / Accepted: 6 May 2013 / Published online: 16 May 2013 The Author(s) 2013. This article is published with open access at Springerlink.comThe aim of the present studies was to evaluate cocaine ...
A Madayag, A Meister, AA Tambe, AJ Cooper, CQ Chen, DA Baker, DA Baker, Danuta Kowalczyk-Pachel, DC Carter, DP Jones, E Bald, E Bald, Elżbieta Lorenc-Koci, G Chwatko, G Lund, GJ McBean, GJ McBean, Grażyna Chwatko, H Refsum, H Sato, H Turhan, HJ Forman, HJ Forman, HL Wiener, I Barutcu, I Dalle-Donne, I Dalle-Donne, JB Dietrich, JD Uys, JE Schnitzer, JI Toohey, JJ Mieyal, JM Mato, Joanna Czyżyk, K Fijał, KM Humphries, KS Kau, KS McCully, L Pomierny-Chamioło, L Włodek, LH Lash, Lidia Włodek, M Conrad, M Iciek, M Kemp, M Muriach, MA Evans, Małgorzata Filip, Małgorzata Iciek, NL Reynaert, O Stanger, P Klatt, P Kovacic, PN Mardikian, PW Beatty, PW Kalivas, R Banerjee, R Castro, R Labib, R Labib, RA Kloner, RC Twining, S Githens, S Kandil, S Sengupta, S Zaina, SA Everett, SC Lu, SD LaRowe, SE Hyman, SH Rezkalla, SL Amen, SZ Mehanny, T Fiaschi, T Visalli, V Vitvitsky, W Tian, W Zhou, YI Kim, YM Go, YM Kupchik   +80 more
core   +2 more sources