Results 51 to 60 of about 956,103 (191)

α-Helix in Cystathionine β-Synthase Enzyme Acts as Electron Reservoir [PDF]

, 2021
The modulation of electron density at the Pyridoxal 5-phosphate (PLP) catalytic center, due to charge transfer across the α-Helix-PLP interface, is the determining factor for the enzymatic activities in the human Cystathionine β-Synthase (hCBS) enzyme ...
Aashish , Bhatt, Aritra, Mukhopadhyaya, Md. Ehesan, Ali   +2 more
core   +1 more source

Cystathionine β-synthase is involved in cysteine biosynthesis and H2S generation in Toxoplasma gondii [PDF]

, 2020
Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine, alpha-ketobutyrate and ammonia by cystathionine gamma-lyase (CGL) in the reverse transsulfuration ...
Martínez-Cruz, Luis Alfonso, Fernández-Rodríguez, Carmen, Dominici, Paola, Astegno, Alessandra, Conter, Carolina, Fruncillo, Silvia   +5 more
core   +1 more source

Frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer. [PDF]

PLoS ONE, 2012
Both gastric and colorectal cancers (CRC) are the most frequently occurring malignancies worldwide with the overall survival of these patients remains unsatisfied.
Hong Zhao, Qinshan Li, Jian Wang, Xianwei Su, Ka Man Ng, Tian Qiu, Ling Shan, Yun Ling, Linfang Wang, Jianqiang Cai, Jianming Ying   +10 more
doaj   +1 more source

Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. [PDF]

, 1995
Studies by various investigators have indicated that elevated levels of plasma homocyst(e)ine are strongly associated with the occurrence of occlusive vascular diseases.
Malinow, M. R., Osada, J., Aratani, Y., Kluckman, K., Watanabe, M., Reddick, R., Maeda, N.   +6 more
core   +1 more source

Impact of Varicocele on The Expression of Testicular Enzymes Involved in The Transsulfuration Pathway [PDF]

International Journal of Fertility and Sterility
Background: Oxidative aggression is a hallmark of varicocele and may depend on decreased reactive ability ofthe endogenous antioxidant system following heat stress.
Azam Shiasi, Marziyeh Tavalaee, Ramesh Monajemi, Dattilo M, Mohammad Hossein Nasr-Esfahani   +4 more
doaj   +1 more source

Colorimetric coupled enzyme assay for cystathionine β-synthase [PDF]

, 2016
A colorimetric coupled enzyme assay for the determination of cystathionine β-synthase activity is described. The method exploits cystathionine γ-lyase as an ancillary enzyme capable of transforming cystathionine, produced by cystathionine β-synthase ...
BALESTRI, FRANCESCO, MOSCHINI, ROBERTA, MURA, UMBERTO, Rocchiccioli, Marco, DEL CORSO, ANTONELLA, Cappiello, Laura, CAPPIELLO, MARIO   +6 more
core   +1 more source

LINF_170008800

, 2021
cystathionine beta-synthase (CYSB) Leishmania infantum (strain ...
Requena, J (via Mendeley Data), Requena, Jose M.   +1 more
core   +1 more source

CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway

Frontiers in Pharmacology, 2023
Hydrogen sulfide (H2S), a gasotransmitter with protective effects in the cardiovascular system, is endogenously generated by three main enzymatic pathways: cystathionine gamma lyase (CTH), cystathionine beta synthase (CBS) and 3-mercaptopyruvate ...
Antonia Katsouda, Antonia Katsouda, Maria Markou, Maria Markou, Paraskevas Zampas, Paraskevas Zampas, Aimilia Varela, Constantinos H. Davos, Valentina Vellecco, Giuseppe Cirino, Mariarosaria Bucci, Andreas Papapetropoulos, Andreas Papapetropoulos   +12 more
doaj   +1 more source

Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding

, 2019
Cystathionine beta-synthase (CBS) plays a key role in the metabolism of sulfur-containing amino acids. CBS is a multidomain tetrameric enzymeallosterically activated by S-adenosylmethionine (AdoMet).
Luis Alfonso Martínez-Cruz (2384026), Jan P. Kraus (6422100), Angel L. Pey (355133), Tomas Majtan (6422097)   +3 more
core   +2 more sources

Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation. [PDF]

PLoS ONE, 2008
Human cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits homocysteine to the synthesis of cysteine. Mutations in CBS are the most common cause of severe hereditary hyperhomocysteinemia.
Nitish Agrawal, Ruma Banerjee
doaj   +1 more source