Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation [PDF]
Redox Biology, 2023 Purpose: Glioblastoma (GBM) is the most common type of adult brain tumor with extremely poor survival. Cystathionine-gamma lyase (CTH) is one of the main Hydrogen Sulfide (H2S) producing enzymes and its expression contributes to tumorigenesis and ...
Maria Peleli
exaly +4 more sources
Methamphetamine causes cardiovascular dysfunction via cystathionine gamma lyase and hydrogen sulfide depletion [PDF]
Redox Biology, 2022 Methamphetamine (METH) is an addictive illicit drug used worldwide that causes significant damage to blood vessels resulting in cardiovascular dysfunction.
Christopher Kevil +2 more
exaly +4 more sources
Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation [PDF]
Redox Biology, 2023 Hydropersulfide and hydropolysulfide metabolites are increasingly important reactive sulfur species (RSS) regulating numerous cellular redox dependent functions.
A Wayne Orr, John D Glawe
exaly +4 more sources
Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids [PDF]
AntioxidantsCystathionine gamma-lyase (CSE) and TNF-α are now recognized as key regulators of intestinal homeostasis, inflammation, and wound healing. In colonic epithelial cells, both molecules have been shown to influence a variety of biological processes, but the
Katalin Módis +2 more
exaly +4 more sources
Cystathionine Gamma Lyase Is Regulated by Flow and Controls Smooth Muscle Migration in Human Saphenous Vein [PDF]
Antioxidants, 2023 The saphenous vein is the conduit of choice for bypass grafting. Unfortunately, the hemodynamic stress associated with the arterial environment of the bypass vein graft leads to the development of intimal hyperplasia (IH), an excessive cellular growth ...
Shuang Zhao +5 more
doaj +2 more sources
Heat Shock Protein 70 in Penile Neurovascular Regeneration Requires Cystathionine Gamma-Lyase [PDF]
The World Journal of Men's Health, 2022 Purpose: Diabetes mellitus, one of the major causes of erectile dysfunction, leads to a poor response to phosphodiesterase-5 inhibitors. Heat shock protein 70 (Hsp70), a ubiquitous molecular chaperone, is known to play a role in cell survival and ...
Kalyan Ghatak +5 more
doaj +2 more sources
Family-Specialized Transformer for L-cystathionine gamma-lyase Engineering and Its Structural Interpretation [PDF]
Computational and Structural Biotechnology JournalHighlights • LLM-driven ecological priors enable large-scale functional labeling of CGL homologs.• EnzFormer integrates ESMC embeddings to accurately predict putative enzyme activity.• In silico screening identifies a distal V129G variant with a 2-fold ...
Ungyu Lee +3 more
doaj +2 more sources
Hydrogen sulfide generated by cystathionine gamma lyase inhibits lysyl oxidase and protects against calcific tendinopathy [PDF]
Journal of Orthopaedic TranslationBackground/objective: Increased lysyl oxidase (LOX) activity favors pathologic cartilage and vessel calcification. LOX promotes disease through enhanced collagen cross-linking, inflammation, reactive oxygen species (ROS) production, cell trans ...
Elodie Faure +9 more
doaj +2 more sources
Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair [PDF]
Cell Communication and Signaling, 2023 Background The inflammatory response induced by intestinal ischaemia‒reperfusion injury (I/R) is closely associated with infectious complications and mortality in critically ill patients, and the timely and effective clearance of apoptotic cells is an ...
Xiao-Hu Zhao +8 more
doaj +2 more sources
Immunoresponsive Gene 1–Itaconate Exacerbates Hypertension by Inhibiting the Cystathionine Gamma-Lyase/Hydrogen Sulfide Pathway [PDF]
Journal of Cardiovascular Development and DiseaseThe role of immunoresponsive gene 1 (IRG1)–itaconate (ITA) in hypertension remains poorly understood. This study aimed to investigate this role and the underlying mechanisms.
Minglu Ma +9 more
doaj +2 more sources