Results 41 to 50 of about 555,922 (178)

Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress

Redox Biology, 2022
Reactive sulfur species (RSS) play a role in redox homeostasis; however, adaptive cell responses to excessive intracellular RSS are not well understood. Therefore, in this study, we generated transgenic (Tg) mice overexpressing cystathionine gamma-lyase (
Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai   +11 more
doaj   +1 more source

Profiling Cystathionine /-Lyase in Complex Biosamples Using Novel Activatable Fluorogens

, 2021
Cystathionine lyase, the key enzyme in transsulfuration and reverse transsulfuration pathways, is involved in a wide array of physiological and pathophysiological processes in both mammals and nonmammals.
Jiayue Wang (3136224), Yiying Wang (3344264), Yanxi Pei (475881), Keli Han (1629946), Yan Jia, Peng Li, Yongli Zhang, Jiayue Wang, Peng Li (69518), Yanxi Pei, Yongli Zhang (274182), Yiying Wang, Keli Han, Zhiqing Wang (830081), Zhiqing Wang, Yan Jia (198590)   +15 more
core   +1 more source

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

eLife, 2021
A fundamental challenge in human immunodeficiency virus (HIV) eradication is to understand how the virus establishes latency, maintains stable cellular reservoirs, and promotes rebound upon interruption of antiretroviral therapy (ART).
Virender Kumar Pal, Ragini Agrawal, Srabanti Rakshit, Pooja Shekar, Diwakar Tumkur Narasimha Murthy, Annapurna Vyakarnam, Amit Singh   +6 more
doaj   +1 more source

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina. [PDF]

Exp Eye Res, 2019
Chronic exposure of the retina to light and high concentrations of polyunsaturated fatty acid in photoreceptor cells make this tissue susceptible to oxidative damage. As retinal degenerative diseases are associated with photoreceptor degeneration, the antioxidant activity of both hydrogen sulfide (H2S) and glutathione (GSH) may play an important role ...
Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD.   +4 more
europepmc   +4 more sources

Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization.

Journal of Biological Chemistry, 1984
Cystathionine gamma-lyase (EC 4.4.1.1) is widely distributed in actinomycetes, e.g. genera Streptomyces, Micromonospora, Micropolyspora, Mycobacterium, Nocardia, Streptosporangium, and Streptoverticillium. The enzyme was purified from Streptomyces phaeochromogenes (IFO 3105) in nine steps.
T, Nagasawa, H, Kanzaki, H, Yamada
openaire   +2 more sources

Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease

Redox Biology, 2018
Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial ...
Saurabh Rajpal, Pavan Katikaneni, Matthew Deshotels, Sibile Pardue, John Glawe, Xinggui Shen, Nuri Akkus, Kalgi Modi, Ruchi Bhandari, Paari Dominic, Pratap Reddy, Gopi K. Kolluru, Christopher G. Kevil   +12 more
doaj   +1 more source

Characterization and Crystal Structure Elucidation of the l-Homoserine O-Succinyltransferase MetXS From Cupriavidus necator H16. [PDF]

Chembiochem
This study reports the identification, heterologous production, and in vitro characterization of the homoserine O‐succinyltransferase from C. necator (CnMetXS). Several biochemical parameters, including the pH and temperature optima, thermostability, substrate scope, and kinetic parameters, are determined, and a high‐resolution X‐ray structure of ...
Meier HPF, Oerlemans R, Terholsen H, Groves MR, Lauterbach L, Schmidt S.   +5 more
europepmc   +2 more sources

Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension

Frontiers in Pharmacology, 2021
Cystathionine gamma-lyase (CSE)/hydrogen sulfide (H2S) plays a protective role in cardiovascular diseases including hypertension and ischemia/reperfusion (I/R) injury.
Yaping Niu, Congkuo Du, Changting Cui, Haizeng Zhang, Yue Deng, Jun Cai, Zhenzhen Chen, Bin Geng, Bin Geng   +8 more
doaj   +1 more source

Impact of Varicocele on The Expression of Testicular Enzymes Involved in The Transsulfuration Pathway [PDF]

International Journal of Fertility and Sterility
Background: Oxidative aggression is a hallmark of varicocele and may depend on decreased reactive ability ofthe endogenous antioxidant system following heat stress.
Azam Shiasi, Marziyeh Tavalaee, Ramesh Monajemi, Dattilo M, Mohammad Hossein Nasr-Esfahani   +4 more
doaj   +1 more source

Cystathionine γ-lyase: Clinical, metabolic, genetic, and structural studies [PDF]

Molecular Genetics and Metabolism, 2009
We report studies of six individuals with marked elevations of cystathionine in plasma and/or urine. Studies of CTH, the gene that encodes cystathionine gamma-lyase, revealed the presence among these individuals of either homozygous or compound heterozygous forms of a novel large deletion, p.Gly57_Gln196del, two novel missense mutations, c.589C>T (p ...
Kraus, Jan P., Hasek, Jindrich, Kozich, Viktor, Collard, Renata, Venezia, Sarah, Janosíková, Bohumila, Wang, Jian, Stabler, Sally P., Allen, Robert H., Jakobs, Cornelis, Finn, Christine T., Chien, Yin-Hsiu, Hwu, Wuh-Liang, Hegele, Robert A., Mudd, S. Harvey   +14 more
openaire   +5 more sources