Results 31 to 40 of about 4,040 (150)

Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells [PDF]

Cardiovascular Research, 2010
Cystathionine gamma-lyase (CSE)-derived H2S plays an important role in regulating cell growth. Lack of CSE expression results in development of hypertension. The current study compared proliferation of smooth muscle cells derived from CSE gene knockout mice (SMCs-KO) with that of wild-type mice (SMCs-WT).Cell proliferation was assessed by ...
Guangdong, Yang, Lingyun, Wu, Sean, Bryan, Neelam, Khaper, Sarathi, Mani, Rui, Wang   +5 more
openaire   +2 more sources

Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase

Redox Biology, 2020
Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using ...
Sergio Rius-Pérez, Salvador Pérez, Isabel Torres-Cuevas, Pablo Martí-Andrés, Raquel Taléns-Visconti, Alberto Paradela, Laura Guerrero, Luis Franco, Gerardo López-Rodas, Luis Torres, Fernando Corrales, Juan Sastre   +11 more
doaj   +1 more source

Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis

Scientific Reports, 2021
Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the ...
Ann-Yae Na, Jung Jae Jo, Oh Kwang Kwon, Piljoung Cho, Yan Gao, Ju-Hyun Kim, Kyu Min Kim, Sung Hwan Ki, Sangkyu Lee   +8 more
doaj   +1 more source

Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress

Redox Biology, 2022
Reactive sulfur species (RSS) play a role in redox homeostasis; however, adaptive cell responses to excessive intracellular RSS are not well understood. Therefore, in this study, we generated transgenic (Tg) mice overexpressing cystathionine gamma-lyase (
Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai   +11 more
doaj   +1 more source

Effects of simultaneous pharmacological inhibition of cystathionine gamma-lyase and nitric oxide synthase on food and water intake, body mass gain, and body temperature in rats [PDF]

Journal of Biomedical & Clinical Research
Various studies have emphasized the intricate relationship between hydrogen sulfide (H2S) and nitric oxide (NO) in regulating diverse physiological processes.
Milen Hristov, Pavlina Andreeva-Gateva
doaj   +3 more sources

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

eLife, 2021
A fundamental challenge in human immunodeficiency virus (HIV) eradication is to understand how the virus establishes latency, maintains stable cellular reservoirs, and promotes rebound upon interruption of antiretroviral therapy (ART).
Virender Kumar Pal, Ragini Agrawal, Srabanti Rakshit, Pooja Shekar, Diwakar Tumkur Narasimha Murthy, Annapurna Vyakarnam, Amit Singh   +6 more
doaj   +1 more source

Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization.

Journal of Biological Chemistry, 1984
Cystathionine gamma-lyase (EC 4.4.1.1) is widely distributed in actinomycetes, e.g. genera Streptomyces, Micromonospora, Micropolyspora, Mycobacterium, Nocardia, Streptosporangium, and Streptoverticillium. The enzyme was purified from Streptomyces phaeochromogenes (IFO 3105) in nine steps.
T, Nagasawa, H, Kanzaki, H, Yamada
openaire   +2 more sources

Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease

Redox Biology, 2018
Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial ...
Saurabh Rajpal, Pavan Katikaneni, Matthew Deshotels, Sibile Pardue, John Glawe, Xinggui Shen, Nuri Akkus, Kalgi Modi, Ruchi Bhandari, Paari Dominic, Pratap Reddy, Gopi K. Kolluru, Christopher G. Kevil   +12 more
doaj   +1 more source

Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension

Frontiers in Pharmacology, 2021
Cystathionine gamma-lyase (CSE)/hydrogen sulfide (H2S) plays a protective role in cardiovascular diseases including hypertension and ischemia/reperfusion (I/R) injury.
Yaping Niu, Congkuo Du, Changting Cui, Haizeng Zhang, Yue Deng, Jun Cai, Zhenzhen Chen, Bin Geng, Bin Geng   +8 more
doaj   +1 more source

Impact of Varicocele on The Expression of Testicular Enzymes Involved in The Transsulfuration Pathway [PDF]

International Journal of Fertility and Sterility
Background: Oxidative aggression is a hallmark of varicocele and may depend on decreased reactive ability ofthe endogenous antioxidant system following heat stress.
Azam Shiasi, Marziyeh Tavalaee, Ramesh Monajemi, Dattilo M, Mohammad Hossein Nasr-Esfahani   +4 more
doaj   +1 more source