Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]
PLoS ONE, 2016 Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis.
Ravinder Reddy Gaddam +7 more
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Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]
PLoS ONE, 2017 [This corrects the article DOI: 10.1371/journal.pone.0160521.].
Ravinder Reddy Gaddam +7 more
doaj +2 more sources
Cystathionine gamma-lyase expression is regulated by exogenous hydrogen peroxide in the mammalian cells. [PDF]
Gene Expr, 2012 Hydrogen sulfide (H2S), as an endogenous signaling molecule in mammals, shows a variety of biological effects. Cystathionine gamma-lyase (CSE)/H2S pathway has been implicated in scavenging reactive oxygen species (ROS) in the mammalian cells. Therefore, we first investigated the regulatory effects of exogenously applied hydrogen peroxide (H2O2) on CSE ...
Wang M, Guo Z, Wang S.
europepmc +4 more sources
Mucosal acidification increases hydrogen sulfide release through up-regulating gene and protein expressions of cystathionine gamma-lyase in the rat gastric mucosa [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): This study was performed to investigate the effects of mucosal acidification on mRNA expression and protein synthesis of cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS), and mucosal release of H2S in gastric mucosa in ...
Seyyed Ali Mard +3 more
doaj +1 more source
Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells [PDF]
International Journal of Molecular Sciences, 2023 Madhav Bhatia +2 more
exaly +2 more sources
Cystathionine gamma lyase and hydrogen sulfide: new players in orthodontic root resorption. [PDF]
Ann Transl Med, 2020 Holliday LS, Dolce C.
europepmc +3 more sources
Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease
Antioxidants, 2023 3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate
Swetha Pavani Rao +3 more
doaj +1 more source
Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis [PDF]
International Journal of Molecular Sciences, 2019 Madhav Bhatia +2 more
exaly +2 more sources
Endogenous Hydrogen Sulfide Is an Important Factor in Maintaining Arterial Oxygen Saturation
Frontiers in Pharmacology, 2021 The gasotransmitter H2S is involved in various physiological and pathophysiological processes. The aim of this study was to investigate the physiological functions of H2S in the lungs.
Yan Huang +11 more
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The Role of Hydrogen Sulfide in Plaque Stability
Antioxidants, 2022 Atherosclerosis is the greatest contributor to cardiovascular events and is involved in the majority of deaths worldwide. Plaque rapture or erosion precipitates life-threatening thrombi, resulting in the obstruction blood flow to the heart (acute ...
Qian Lin, Bin Geng
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