Mucosal acidification increases hydrogen sulfide release through up-regulating gene and protein expressions of cystathionine gamma-lyase in the rat gastric mucosa [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): This study was performed to investigate the effects of mucosal acidification on mRNA expression and protein synthesis of cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS), and mucosal release of H2S in gastric mucosa in ...
Seyyed Ali Mard +3 more
doaj +2 more sources
Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene. [PDF]
PLoS ONE, 2014 Hydrogen sulfide (H2S) is an important gaseous signaling molecule that functions in physiological and pathological conditions, such as atherosclerosis. H2S dilates vessels and therefore has been suggested as an anti-atherogenic molecule.
Sau Ha Cheung +3 more
doaj +2 more sources
Cystathionine Gamma-Lyase: A Potential Longevity Gene Under Selection? [PDF]
Journal of Molecular EvolutionHydrogen sulfide (H2S) plays a crucial role in various physiological processes and has been implicated in modulating aging through its impacts on oxidative stress and cellular health. This study investigates the evolutionary dynamics of the cystathionine-β-synthase (CBS), the cystathionine-ƴ-lyase (CSE), and the 3-mercaptopyruvate sulfurtransferase (3 ...
Gary J. Ren +4 more
openaire +3 more sources
Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]
PLoS ONE, 2016 Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis.
Ravinder Reddy Gaddam +7 more
doaj +2 more sources
Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]
PLoS ONE, 2017 [This corrects the article DOI: 10.1371/journal.pone.0160521.].
Ravinder Reddy Gaddam +7 more
doaj +2 more sources
Biology Open, 2015 In addition to its role in the endogenous synthesis of cysteine, cystathionine gamma-lyase (CGL) is a major physiological source of the vasorelaxant hydrogen sulfide.
Hua Jiang +6 more
doaj +2 more sources
Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells [PDF]
International Journal of Molecular Sciences, 2023 Madhav Bhatia +2 more
exaly +2 more sources
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors. [PDF]
Anticancer Res, 2021 Testicular cancer constitutes 1.0% of male cancer and typically carries a good prognosis. As far as we are aware, the role for hydrogen sulfide in testicular cancer and the level of hydrogen sulfide-synthesizing enzyme have never been addressed. Here we examined cystathionine gamma-lyase (CSE) expression in several germ-cell testicular tumors.Tissue ...
Ozluk E +6 more
europepmc +4 more sources
Cystathionine gamma lyase aggravates orthodontic root resorption in mice. [PDF]
Ann Transl Med, 2019 This study aimed to determine the contribution of cystathionine gamma lyase (CSE) to physiological and orthodontic root resorption in mice.Mice genetically deficient in the CSE (CSE-/-), the dominant hydrogen sulfide (H2S)-generating enzyme in osteoclast were used in this study.
Lu C, Chen L, Hua Y.
europepmc +4 more sources
Effect of cysteine on the inactivation of cystathionine gamma-lyase by D,L-propargylglycine.
Effect of cysteine on the inactivation of cystathionine gamma-lyase by D,L-propargylglycine.In vivo inactivation of cystathionine gamma-lyase by D,L-propargylglycine, a suicide inhibitor, was found to be less profound in rat kidney than in the liver. We investigated the cause of this difference using rat tissues. We fractionated kidney extract to characterize the substance which protected enzyme, and found that cysteine exhibits protecting ...
Kodama, Hiroyuki +3 more
openaire +2 more sources