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Cystathionine gamma-lyase deficiency exaggerates diethylnitrosamine-induced liver damage in mice
Nitric Oxide - Biology and ChemistryCystathionine gamma-lyase (CSE) is a key enzyme in reverse transsulfuration pathway and contributes to the majority of H2S generation in liver tissues via cysteine metabolism.
Guangdong Yang
exaly +4 more sources
Journal of Molecular and Cellular Cardiology, 2022
Enzymatic degradation of elastin by matrix metalloproteinases (MMPs) leads to the permanent dilation of aortic wall and constitutes the most prominent characters of aortic aneurysm and aging-related medial degeneration.
Yuehong Wang +2 more
exaly +2 more sources
Enzymatic degradation of elastin by matrix metalloproteinases (MMPs) leads to the permanent dilation of aortic wall and constitutes the most prominent characters of aortic aneurysm and aging-related medial degeneration.
Yuehong Wang +2 more
exaly +2 more sources
Cystathionine gamma‐lyase/H 2 S signaling facilitates myogenesis under aging and injury condition
FASEB Journal, 2021Hydrogen sulfide (H2S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma‐lyase (CSE)‐derived H2S is implicated in the regulation of cell differentiation and the aging process, but ...
Yanjie Zhang +2 more
exaly +2 more sources
Cystathionine Gamma-Lyase: A Potential Longevity Gene Under Selection?
Journal of Molecular EvolutionHydrogen sulfide (H2S) plays a crucial role in various physiological processes and has been implicated in modulating aging through its impacts on oxidative stress and cellular health. This study investigates the evolutionary dynamics of the cystathionine-β-synthase (CBS), the cystathionine-ƴ-lyase (CSE), and the 3-mercaptopyruvate sulfurtransferase (3 ...
Gary J. Ren +4 more
semanticscholar +3 more sources
Journal of Thermal Biology, 2023
Leptin is an adipokine that regulates energy balance and immune function. Peripheral leptin administration elicits prostaglandin E₂-dependent fever in rats.
M. Hristov, L. Lazarov
semanticscholar +1 more source
Leptin is an adipokine that regulates energy balance and immune function. Peripheral leptin administration elicits prostaglandin E₂-dependent fever in rats.
M. Hristov, L. Lazarov
semanticscholar +1 more source
Cystathionine gamma lyase (CSE) deficiency promotes increased contraction of the corpus cavernosum
Physiology, 2023Cystathionine γ lyase (CSE) is the primary enzyme responsible for hydrogen sulfide (H2S) production in the vasculature. Although, it is known that H2S is a vasodilator systemically, little is known about the effect of CSE on the arteries and tissues ...
T. Azeez +2 more
semanticscholar +1 more source
Circulation, 2022
While the causative factors of smoking and hypertension leading to cardiovascular disease (CVD) are well understood, those involved with diet-induced CVD are not. One metabolite regulated by diet that is involved with cardio-protection and vasodilation
Betemariam Sharew +4 more
semanticscholar +1 more source
While the causative factors of smoking and hypertension leading to cardiovascular disease (CVD) are well understood, those involved with diet-induced CVD are not. One metabolite regulated by diet that is involved with cardio-protection and vasodilation
Betemariam Sharew +4 more
semanticscholar +1 more source
Gastroenterology
Current combination therapies in ulcerative colitis (UC) target different inflammatory cascades, including tumor necrosis factor-alpha (TNF-alpha) signaling.
G. Toro +9 more
semanticscholar +1 more source
Current combination therapies in ulcerative colitis (UC) target different inflammatory cascades, including tumor necrosis factor-alpha (TNF-alpha) signaling.
G. Toro +9 more
semanticscholar +1 more source