Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors. [PDF]
Anticancer Res, 2021 Testicular cancer constitutes 1.0% of male cancer and typically carries a good prognosis. As far as we are aware, the role for hydrogen sulfide in testicular cancer and the level of hydrogen sulfide-synthesizing enzyme have never been addressed. Here we examined cystathionine gamma-lyase (CSE) expression in several germ-cell testicular tumors.Tissue ...
Ozluk E +6 more
europepmc +4 more sources
Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease
Antioxidants, 2023 3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate
Swetha Pavani Rao +3 more
doaj +1 more source
Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms. [PDF]
Antioxid Redox Signal, 2016 Aims: To investigate the regulation of hepatic glucose production by cystathionine γ-lyase (CSE)-generated hydrogen sulfide (H 2 S) in hepatic glucose production under physiological conditions.
Untereiner AA, Wang R, Ju Y, Wu L.
europepmc +4 more sources
Cystathionine gamma lyase and hydrogen sulfide: new players in orthodontic root resorption. [PDF]
Ann Transl Med, 2020 Holliday LS, Dolce C.
europepmc +3 more sources
Endogenous Hydrogen Sulfide Is an Important Factor in Maintaining Arterial Oxygen Saturation
Frontiers in Pharmacology, 2021 The gasotransmitter H2S is involved in various physiological and pathophysiological processes. The aim of this study was to investigate the physiological functions of H2S in the lungs.
Yan Huang +11 more
doaj +1 more source
Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis [PDF]
International Journal of Molecular Sciences, 2019 Madhav Bhatia +2 more
exaly +2 more sources
The Role of Hydrogen Sulfide in Plaque Stability
Antioxidants, 2022 Atherosclerosis is the greatest contributor to cardiovascular events and is involved in the majority of deaths worldwide. Plaque rapture or erosion precipitates life-threatening thrombi, resulting in the obstruction blood flow to the heart (acute ...
Qian Lin, Bin Geng
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Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells [PDF]
Cardiovascular Research, 2010 Cystathionine gamma-lyase (CSE)-derived H2S plays an important role in regulating cell growth. Lack of CSE expression results in development of hypertension. The current study compared proliferation of smooth muscle cells derived from CSE gene knockout mice (SMCs-KO) with that of wild-type mice (SMCs-WT).Cell proliferation was assessed by ...
Guangdong, Yang +5 more
openaire +2 more sources
Cystathionine γ-lyase: Clinical, metabolic, genetic, and structural studies [PDF]
Molecular Genetics and Metabolism, 2009 We report studies of six individuals with marked elevations of cystathionine in plasma and/or urine. Studies of CTH, the gene that encodes cystathionine gamma-lyase, revealed the presence among these individuals of either homozygous or compound heterozygous forms of a novel large deletion, p.Gly57_Gln196del, two novel missense mutations, c.589C>T (p ...
Kraus, Jan P. +14 more
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Redox Biology, 2020 Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using ...
Sergio Rius-Pérez +11 more
doaj +1 more source