H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes [PDF]
Scientific Reports, 2017 Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.
Shyam Sundar Nandi, Paras Kumar Mishra
doaj +6 more sources
Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids [PDF]
AntioxidantsCystathionine gamma-lyase (CSE) and TNF-α are now recognized as key regulators of intestinal homeostasis, inflammation, and wound healing. In colonic epithelial cells, both molecules have been shown to influence a variety of biological processes, but the
Francisco Arroyo Almenas +10 more
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Acta Physiologica, 2023 In extracerebral vascular beds cystathionine‐gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H2S) producing enzyme in the intracerebral arterioles remain poorly understood. We hypothesized a similar function in
Jane STUBBE, Kristina Lyngsø
exaly +6 more sources
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors. [PDF]
Anticancer Res, 2021 Background: Testicular cancer constitutes 1.0% of male cancer and typically carries a good prognosis. As far as we are aware, the role for hydrogen sulfide in testicular cancer and the level of hydrogen sulfide-synthesizing enzyme have never been ...
Ozluk E +6 more
europepmc +5 more sources
Cystathionine Gamma-Lyase Regulate Psilocybin Biosynthesis in Gymnopilus dilepis Mushroom via Amino Acid Metabolism Pathways [PDF]
Journal of Fungi, 2022 As a potential medicine for the treatment of depression, psilocybin has gradually attracted attention. To elucidate the molecular mechanism regulating psilocybin synthesis in Gymnopilus dilepis, ultra-performance liquid chromatography (UPLC) was used to ...
Sen Yao +7 more
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NRF2 Regulates Cystathionine Gamma-Lyase Expression and Activity in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus [PDF]
Antioxidants, 2022 Cystathionine-y-lyase (CSE) is a critical enzyme for hydrogen sulfide (H2S) biosynthesis and plays a key role in respiratory syncytial virus (RSV) pathogenesis.
Mohammad Jamaluddin +5 more
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Cystathionine gamma-lyase-mediated hypoxia inducible factor 1-alpha expression drives clear cell ovarian cancer progression. [PDF]
J PatholClear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%–11% of ovarian cancers in North America. Late‐stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, a challenge ...
El-Naggar AM +27 more
europepmc +2 more sources
Differential Roles of Cystathionine Gamma-Lyase and Mercaptopyruvate Sulfurtransferase in Hapten-Induced Colitis and Contact Dermatitis in Mice. [PDF]
Int J Mol Sci, 2023 Hydrogen sulfide (H2S) has been shown to act as both anti-inflammatory and pro-inflammatory mediators. Application of H2S donors generally protects against inflammation; however, experimental results using mice lacking endogenous H2S-producing enzymes ...
Akahoshi N +6 more
europepmc +2 more sources
Retraction notice to "Bioinformatic analyzes and validation of cystathionine gamma-lyase as a prognostic biomarker and related to immune infiltrates in hepatocellular carcinoma" [Heliyon 9 (2023) e16152]. [PDF]
Heliyon[This retracts the article DOI: 10.1016/j.heliyon.2023.e16152.].
Xiang J +9 more
europepmc +2 more sources
Effects of simultaneous pharmacological inhibition of cystathionine gamma-lyase and nitric oxide synthase on food and water intake, body mass gain, and body temperature in rats [PDF]
Journal of Biomedical & Clinical ResearchVarious studies have emphasized the intricate relationship between hydrogen sulfide (H2S) and nitric oxide (NO) in regulating diverse physiological processes.
Milen Hristov, Pavlina Andreeva-Gateva
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