Results 31 to 40 of about 7,941 (171)

The Dysregulation of microRNA-30b Directly Regulates Cystathionine Gamma-Lyase and Exhibits Poor Invasion Activity in Preeclampsia. [PDF]

Cureus
Background and objective Preeclampsia (PE) is a severe pregnancy complication characterized by high blood pressure and proteinuria after 23 weeks of gestation. Insufficient trophoblast invasion has been linked to its development.
Saxena S, John BA, Verma N, Mishra M.
europepmc   +2 more sources

Association of Kidney Graft Long-term Outcome With Recipient Cystathionine Gamma-lyase Polymorphisms and Hydrogen Sulfide Levels: A Cohort Study. [PDF]

Transplant Direct
Background. Hydrogen sulfide (H2S) produced endogenously by the CTH gene-encoded cystathionine gamma-lyase protects from renal ischemia–reperfusion injury in preclinical models.
Halfon M, Emsley R, Agius T, Lyon A, Déglise S, Pascual M, Uygun K, Yeh H, Riella LV, Markmann JF, Bochud PY, Golshayan D, Longchamp A.   +12 more
europepmc   +2 more sources

Cystathionine gamma-lyase as an inflammatory factor and its link with immune inflammation in hepatitis B virus-related liver disease. [PDF]

Sci Rep
We aimed to explore the effectiveness of CTH as a serum inflammation biomarker for HCC. Enzyme-linked immunosorbent assay was used to detect serum levels of CTH, interleukin-6 (IL-6), C-reactive protein (CRP), and IL-10.
Jin C, Hu B, Liu H, Wang R, Jang J, Su M.   +5 more
europepmc   +2 more sources

Cystathionine-gamma-lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy. [PDF]

Cancer Sci, 2021
T cells could be engineered to overcome the aberrant metabolic milieu of solid tumors and tip the balance in favor of a long‐lasting clinical response.
Lancien M, Gueno L, Salle S, Merieau E, Beriou G, Nguyen TH, Abidi A, Dilek N, Solomon P, Poschmann J, Michielin O, Vuillefroy de Silly R, Vanhove B, Louvet C.   +13 more
europepmc   +2 more sources

Family-Specialized Transformer for L-cystathionine gamma-lyase Engineering and Its Structural Interpretation. [PDF]

Comput Struct Biotechnol J
Highlights • LLM-driven ecological priors enable large-scale functional labeling of CGL homologs.• EnzFormer integrates ESMC embeddings to accurately predict putative enzyme activity.• In silico screening identifies a distal V129G variant with a 2-fold ...
Lee U, Park M, Song B, Ha NC.
europepmc   +2 more sources

Cystathionine gamma lyase overexpression enhances neovascularization through NAD-dependent mechanisms

bioRxiv, 2022
Objective Hydrogen sulfide (H2S) is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-gamma-lyase (CGL). CGL-dependant H2S production is required for neovasculariation in models of peripheral arterial disease.
Kiesworo K, MacArthur MR, Kip P, Agius T, Macabrey D, Lambelet M, Hamard L, Ozaki C, Mitchell JR, Déglise S, Mitchell SJ, Allagnat F, Longchamp A.   +12 more
europepmc   +2 more sources

Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene. [PDF]

PLoS ONE, 2014
Hydrogen sulfide (H2S) is an important gaseous signaling molecule that functions in physiological and pathological conditions, such as atherosclerosis. H2S dilates vessels and therefore has been suggested as an anti-atherogenic molecule.
Sau Ha Cheung, Wai Kei Kwok, Ka Fai To, James Yun Wong Lau   +3 more
doaj   +2 more sources

Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]

PLoS ONE, 2016
Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis.
Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia   +7 more
doaj   +2 more sources

Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]

PLoS ONE, 2017
[This corrects the article DOI: 10.1371/journal.pone.0160521.].
Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia   +7 more
doaj   +2 more sources

Immunoresponsive Gene 1–Itaconate Exacerbates Hypertension by Inhibiting the Cystathionine Gamma-Lyase/Hydrogen Sulfide Pathway

Journal of Cardiovascular Development and Disease
The role of immunoresponsive gene 1 (IRG1)–itaconate (ITA) in hypertension remains poorly understood. This study aimed to investigate this role and the underlying mechanisms.
Minglu Ma, Chenyu Fan, Shuping Han, Hu Wang, Yuzhou Xue, Boyang Lv, He Huang, Hongfang Jin, Ling Jin, Jian Liu   +9 more
doaj   +2 more sources