Volatile Sulfur Compounds as a Predictor for Esophagogastroduodenal Mucosal Injury
Gut and Liver, 2008 Background/Aims: Halitosis is a symptom that bothers patients more socially than medically and its pathogenic mechanisms are unclear and treatment armamenterium is limited. Clinicians generally ignored active interventions.
doaj +1 more source
A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery [PDF]
, 2017 Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated.
Alexander, Stephen P.H. +6 more
core +2 more sources
Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]
, 2016 The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE +10 more
core +1 more source
Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity
Redox Biology, 2021 Duchenne muscular dystrophy (DMD) is the most frequent X chromosome-linked disease caused by mutations in the gene encoding for dystrophin, leading to progressive and unstoppable degeneration of skeletal muscle tissues.
E. Panza +11 more
doaj +1 more source
Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii [PDF]
, 2018 Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial enzymes ...
Astegno, A. +6 more
core +2 more sources
Mucosal acidification increases hydrogen sulfide release through up-regulating gene and protein expressions of cystathionine gamma-lyase in the rat gastric mucosa [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): This study was performed to investigate the effects of mucosal acidification on mRNA expression and protein synthesis of cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS), and mucosal release of H2S in gastric mucosa in ...
Seyyed Ali Mard +3 more
doaj
Orphanet Journal of Rare Diseases, 2022 Background Betaine is an “alternate” methyl donor for homocysteine remethylation catalyzed by betaine homocysteine methyltransferase (BHMT), an enzyme mainly expressed in the liver and kidney.
Apolline Imbard +14 more
doaj +1 more source
Dental complications in homocystinurias
Molecular Genetics and Metabolism Reports, 2023 Background: Cystathionine beta synthase deficiency (causing classical homocystinuria) has been associated with high-arched palates and crowded teeth, but little has been said about other oral health complications.
Kimberly A. Chapman +4 more
doaj +1 more source
Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhage [PDF]
Journal of Neurosurgery, 2018 OBJECTIVECystathionine β-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism. Both products have been implicated in the pathophysiology of cerebrovascular diseases. The impact of CBS polymorphisms on aneurysmal subarachnoid hemorrhage (aSAH) and its clinical sequelae is poorly understood.METHODSBlood samples from all ...
Philipp, Hendrix +12 more
openaire +2 more sources
Biomédica: revista del Instituto Nacional de Salud, 2010 Introducción. Se produce trombosis cuando en el sistema hemostático se desequilibran los mecanismos procoagulantes, anticoagulantes y fibrinolíticos, y se forman coágulos dentro de los vasos sanguíneos.
Claudia Ayala +4 more
doaj +1 more source