Results 101 to 110 of about 12,878 (190)

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Engineering of methionine-auxotroph Escherichia coli via parallel evolution of two enzymes from Corynebacterium glutamicum's direct-sulfurylation pathway enables its recovery in minimal medium

Metabolic Engineering Communications
Methionine biosynthesis relies on the sequential catalysis of multiple enzymes. Escherichia coli, the main bacteria used in research and industry for protein production and engineering, utilizes the three-step trans-sulfurylation pathway catalyzed by L ...
Matan Gabay, Inbar Stern, Nadya Gruzdev, Adi Cohen, Lucia Adriana-Lifshits, Tamar Ansbacher, Itamar Yadid, Maayan Gal   +7 more
doaj   +1 more source

Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases

Neural Regeneration Research, 2020
Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main ...
Rubaiya Tabassum, Na Young Jeong, Junyang Jung   +2 more
doaj   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril

Aging Cell, Volume 25, Issue 2, February 2026.
Assessment of oxygen consumption rates in young, middle‐aged, and old flies from the Drosophila B lines and long‐lived O lines revealed a significant increase in metabolic rate with aging only in B flies. Lisinopril prevented the age‐related rise in metabolic rate in B female flies.
Denise Vecchié, Robert R. H. Anholt, Trudy F. C. Mackay, Maria De Luca   +3 more
wiley   +1 more source

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo

Frontiers in Pharmacology
Glioblastoma (GBM) is the most commonly occurring and most aggressive primary brain tumor. Transcriptomics-based tumor subtype classification has established the mesenchymal lineage of GBM (MES-GBM) as cancers with particular aggressive behavior and high
Renfei Du, Renfei Du, Ahmed Y. Sanin, Wenjie Shi, Bing Huang, Bing Huang, Ann-Christin Nickel, Andres Vargas-Toscano, Shuran Huo, Thomas Nickl-Jockschat, Claudia A. Dumitru, Wei Hu, Siyu Duan, I. Erol Sandalcioglu, Roland S. Croner, Joshua Alcaniz, Wolfgang Walther, Carsten Berndt, Ulf D. Kahlert   +18 more
doaj   +1 more source

Toxic Tear Gas 2‐Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure

Drug Testing and Analysis, Volume 18, Issue 1, Page 74-84, January 2026.
Incubation of human plasma with the tear gas 2‐chloroacetophenone (CN) led to the formation of acetophenone (AcPhen)‐adducts with the small plasma thiols glutathione, homocysteine, and cysteine persulfide. The AcPhen‐adducts were either bound to an organic thiol‐group or to an organic persulfide. The adducts were detected with a mass spectrometry‐based
Paula Helena Sieber, Dirk Steinritz, Franz Worek, Harald John   +3 more
wiley   +1 more source

Cystathionine Beta Synthase as a Risk Factor for Alzheimer Disease

Current Alzheimer Research, 2004
One of the known risk factors for developing Alzheimer disease (AD) is hyperhomocysteinemia. The latter may result from mutations of the genes coding for three key enzymes involved in homocysteine metabolism (methylenetetrahydrofolate reductase [MTHFR], methionine synthase [MS], and cystathionine beta-synthase [CBS]).
Beyer, K, Lao, JI, Carrato, C, Rodriguez-Vila, A, Latorre, P, Mataro, M, Llopis, MA, Mate, JL, Ariza, A   +8 more
openaire   +5 more sources

Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury [PDF]

, 2016
Hydrogen sulfide (H2S) is known to act protectively during renal ischemia/reperfusion injury (IRI). However, the role of the endogenous H2S in acute kidney injury (AKI) is largely unclear.
Anders, Juliane, Balogh, Andras, Filipovic, Milos R., Gollasch, Maik, Ishii, Isao, Kassmann, Mario, Kramer, Stephanie, Marko, Lajos, Mueller, Dominik N., N'diaye, Gabriele, Park, Joon-Keun, Przybyl, Lukasz, Szijarto, Istvan A.   +12 more
core   +2 more sources

Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics

Prostate Cancer, 2016
Hydrogen sulfide (H2S) was originally considered toxic at elevated levels; however just in the past decade H2S has been proposed to be an important gasotransmitter with various physiological and pathophysiological roles in the body.
Mingzhe Liu, Lingyun Wu, Sabine Montaut, Guangdong Yang   +3 more
doaj   +1 more source

Methionine Adenosyltransferase I/III Deficiency in Portugal: High Frequency of a Dominantly Inherited Form in a Small Area of Douro High Lands [PDF]

, 2012
Methionine adenosyltransferase deficienc(MAT I/III deficiency) is an inborn error of metabolism resulting in isolated hypermethioninemia, and usually inherited as an autosomal recessive trait, although a dominant form has been reported in several ...
E Martins, I Baric, I Pérez Mato, JY Chou, M Linnebank, ME Chamberlin, ME Chamberlin, ME Chamberlin, MS Rashed, SH Mudd, SH Mudd, SP Stabler, Y Chien   +12 more
core   +1 more source