Results 91 to 100 of about 975,983 (211)

Cross‐species transcriptomics uncovers shared responses to water deficiency in plants

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract Deepening our knowledge of conserved molecular mechanisms governing stress responses in plants is fundamental for identifying new core genes and processes involved in tolerance to adverse environmental conditions. For this purpose, we developed a bioinformatic pipeline to retrieve and integrate stress‐related RNA‐seq transcriptomic data from ...
Francesco Punzi, Diana Lucia Zuluaga, Qiao Wen Tan, Marek Mutwil, Gabriella Sonnante, Pasquale Luca Curci   +5 more
wiley   +1 more source

Structure of human cystathionine beta-synthase : a unique pyridoxal 5'-phosphate-dependent heme protein

, 2001
Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.
Kraus, J. P., Janosik, M., Burkhard, P., Meier, M., Kery, V., Kraus JP, Kery V, Meier M, Janosik M, Burkhard P   +9 more
core   +1 more source

Mucosal acidification increases hydrogen sulfide release through up-regulating gene and protein expressions of cystathionine gamma-lyase in the rat gastric mucosa [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): This study was performed to investigate the effects of mucosal acidification on mRNA expression and protein synthesis of cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS), and mucosal release of H2S in gastric mucosa in ...
Seyyed Ali Mard, Ali Veisi, Akram Ahangarpour, Mohammad Kazem Gharib-Naseri   +3 more
doaj  

Essential Oral Single Nutritional Therapy Products for Inherited Metabolic Diseases: Evidence and Consensus Assessment Using a Modified Delphi Method

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Nutritional therapy is critical in managing inherited metabolic diseases (IMDs), and includes specialized diets and single nutritional therapy products (sNTPs) such as vitamins, cofactors, and amino acids. Many sNTPs function as medicines, but are regulated as food (e.g., food supplements), which can limit access, reimbursement, and consistent
Nina N. Stolwijk, Bart M. F. Penninx, Annet M. Bosch, Mirjam Langeveld, Gajja S. Salomons, Carla E. M. Hollak, Essential Nutritional Therapy Products for IMDs Consensus Group, Dorothea Möslinger, Saskia Wortmann, David Cassiman, Pavel Ješina, Jiri Zeman, Allan M. Lund, François Feillet, Nazi Tabatadze, Sarah C. Grünert, Anke Schumann, Ute Spiekerkoetter, Ulrike Mütze, Thomas Opladen, Anastasia Skouma, Ina Knerr, Serena Gasperini, Vincenza Gragnaniello, Mariarosa (Marina) Anna Beatrice Melone, Francesca Nardecchia, Alessandro La Rosa, Birutė Tumienė, Margreet Wagenmakers, Terry Derks, Camilla Tøndel, Beata Kieć‐Wilk, Urh Groselj, Amaya Bélanger‐Quintana, Javier De las Heras, Mireia del Toro Riera, Eva Venegas Moreno, Matthias Gautschi, Johannes Häberle, Elaine Murphy   +39 more
wiley   +1 more source

Polymorphisms of cystathionine beta-synthase gene are associated with susceptibility to sepsis. [PDF]

Eur J Hum Genet, 2016
Sepsis is the systemic inflammatory host response to infection. Cystathionine beta-synthase (CBS)-dependent homocysteine (Hcy) pathway was demonstrated to affect disease severity and mortality in patients with severe sepsis/septic shock. Independent studies identified a single-nucleotide polymorphism (SNP, rs6586282, hg19 chr21:g.44478497C>T) in intron
Sponholz C, Kramer M, Schöneweck F, Menzel U, Inanloo Rahatloo K, Giamarellos-Bourboulis EJ, Papavassileiou V, Lymberopoulou K, Pavlaki M, Koutelidakis I, Perdios I, Scherag A, Bauer M, Platzer M, Huse K.   +14 more
europepmc   +5 more sources

Dental complications in homocystinurias

Molecular Genetics and Metabolism Reports, 2023
Background: Cystathionine beta synthase deficiency (causing classical homocystinuria) has been associated with high-arched palates and crowded teeth, but little has been said about other oral health complications.
Kimberly A. Chapman, Danae Bartke, Vanessa Vogel-Farley, Mary Cobb, Mary Chapman   +4 more
doaj   +1 more source

Characterization and Crystal Structure Elucidation of the l‐Homoserine O‐Succinyltransferase MetXS From Cupriavidus necator H16

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This study reports the identification, heterologous production, and in vitro characterization of the homoserine O‐succinyltransferase from C. necator (CnMetXS). Several biochemical parameters, including the pH and temperature optima, thermostability, substrate scope, and kinetic parameters, are determined, and a high‐resolution X‐ray structure of ...
Hannah Pia Franziska Meier, Rick Oerlemans, Henrik Terholsen, Matthew R. Groves, Lars Lauterbach, Sandy Schmidt   +5 more
wiley   +1 more source

Caracterização molecular da enzima cistationina β-sintase (cβs) em Trypanosoma rangeli [PDF]

, 2014
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Trypanosoma rangeli é um parasitos hemoflagelados que infecta insetos e mamíferos. Possuem um sistema de resposta antioxidante baseada no ditiol tripanotiona
Yamanaka, Lais Eiko
core  

Expression of cystathionine beta-synthase and histopathological observations in placentas of patients with down syndrome

, 2015
Down syndrome is the most frequent aneuploidy in live births, with an overall frequency of 1/600-700 births. The overexpression of cystathionine β-synthase is thought to participate in the presentation of some phenotypes observed in Down syndrome ...
Olaya-C, M., J. Martínez, Pinilla, García-Robles, R., Ayala-Ramírez, P., Bermúdez, M.   +4 more
core   +2 more sources

Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial

Orphanet Journal of Rare Diseases, 2022
Background Betaine is an “alternate” methyl donor for homocysteine remethylation catalyzed by betaine homocysteine methyltransferase (BHMT), an enzyme mainly expressed in the liver and kidney.
Apolline Imbard, Artemis Toumazi, Sophie Magréault, Nuria Garcia-Segarra, Dimitri Schlemmer, Florentia Kaguelidou, Isabelle Perronneau, Jérémie Haignere, Hélène Ogier de Baulny, Alice Kuster, François Feillet, Corinne Alberti, Sophie Guilmin-Crépon, Jean-François Benoist, Manuel Schiff   +14 more
doaj   +1 more source