Results 101 to 110 of about 26,277 (182)

Cystathionine beta synthase modulates senescence of human endothelial cells

Aging, 2012
Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood.
Albertini, Eva, Koziel, Rafal, Dürr, Angela, Neuhaus, Michael, Jansen-Dürr, Pidder   +4 more
openaire   +3 more sources

Effect of Cysteine on Expression of Cystathionine .BETA.-Synthase in the Rat Liver.

Journal of Nutritional Science and Vitaminology, 1995
Hepatic cystathionine beta-synthase activity is decreased by the addition of cysteine to the diet. This effect of cysteine was slightly greater in diets containing 0.25% methionine than in those containing 1% methionine, and was reduced during aging.
YAMAMOTO, Nobuko, TANAKA, Takehiko, NOGUCHI, Tamio   +2 more
openaire   +3 more sources

Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics

Prostate Cancer, 2016
Hydrogen sulfide (H2S) was originally considered toxic at elevated levels; however just in the past decade H2S has been proposed to be an important gasotransmitter with various physiological and pathophysiological roles in the body.
Mingzhe Liu, Lingyun Wu, Sabine Montaut, Guangdong Yang   +3 more
doaj   +1 more source

Hydrogen Sulfide Reduces Myeloid-Derived Suppressor Cell-Mediated Inflammatory Response in a Model of Helicobacter hepaticus-Induced Colitis

Frontiers in Immunology, 2018
Chronic inflammation contributes to tumor initiation in colitis-associated colorectal cancer (CRC). Indeed, inflammatory bowel disease (IBD) patients show an increased risk of developing CRC.
Paola De Cicco, Theodore Sanders, Giuseppe Cirino, Kevin J. Maloy, Angela Ianaro   +4 more
doaj   +1 more source

Unraveling CBS Mutations and Their Clinical Impact in a Chinese Family With Classical Homocystinuria

Molecular Genetics & Genomic Medicine
Background Classical homocystinuria (HCU), caused by cystathionine beta‐synthase (CBS) deficiency, exhibits significant geographic variability in its mutational spectrum.
Jingfei Zhang, Xinyu Lin, Xinmei Liu, Yilu Lu, Dachang Tao, Dan Yu, Yongxin Ma   +6 more
doaj   +1 more source

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes

Biomolecules
Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta, Klaudia Janik, Leszek Rydz, Maria Wróbel, Halina Jurkowska   +4 more
doaj   +1 more source

Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018
Hydrogen sulfide (H2S) is an essential neuromodulator, generates by cystathionine β synthase (CBS) or 3-mecaptopyruvate sulfurtransferase (3MST) in the brain.
Fengjiao Zheng, Jingnan Han, Haocheng Lu, Changting Cui, Jichun Yang, Qinghua Cui, Jun Cai, Yong Zhou, Chao-shu Tang, Guoheng Xu, B. Geng   +10 more
semanticscholar   +1 more source

Domain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases

PLoS ONE, 2014
Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine. Although the pathway itself is well conserved among eukaryotes, properties of eukaryotic CBS enzymes vary greatly.
Majtan, Tomas, Pey Rodríguez, Ángel Luis, Fernández, Roberto, Fernández, José A., Martínez-Cruz, Luis A., Kraus, Jan P.   +5 more
openaire   +6 more sources

Recurrent venous thrombosis in an adolescent male with CBS mutation and persistent antiphospholipid antibody positivity: a case report

Thrombosis Journal
Homocysteine (Hcy) contributes to endothelial dysfunction and impaired thrombolysis, and genetic polymorphisms that elevate plasma Hcy concentrations have been linked to an increased risk of thrombosis. Notably, mutations in the cystathionine β-synthase (
Yuebing Wang, Ru Li, Chun Li
doaj   +1 more source

Enhancing Postharvest Quality of Fresh-Cut Changgen Mushrooms by Exogenous L-Cysteine Treatment: Aspects of Accumulating Amino Acids, Triggering Energy Metabolism and Enhancing Endogenous H₂S Regulation

Foods
As a rare and functional edible mushroom, the market potential of ready-to-eat fresh-cut Changgen mushrooms (Oudemansiella raphanipes) is booming in developing countries.
Xingchi Ma, Tianhao Li, Weijian Mao, Yu Zhang, Haoran Liu, Wenwen Jiang, Yanan Sun, Hao Yu, Fansheng Cheng, Dan Zhu   +9 more
doaj   +1 more source