Results 221 to 230 of about 19,945,001 (395)

Differential Organ Ageing Is Associated With Age‐Related Macular Degeneration

open access: yesAging Cell, Volume 24, Issue 5, May 2025.
Using the UK Biobank, this study trained neural networks to estimate the biological age of individuals according to markers of organ function. Computing the difference between the estimated organ age and chronological age yielded an estimate for accelerated or slowed ageing.
Anastasios Papadam   +2 more
wiley   +1 more source

Interaction of Cystatin C Variants with Papain and Human Cathepsins B, H and L

open access: bronze, 1999
Nina Cimerman   +5 more
openalex   +1 more source

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments

open access: yesAging Cell, EarlyView.
The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel   +17 more
wiley   +1 more source

Identifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study

open access: yesAging Cell, EarlyView.
Integration of multi‐omics analyses reveals PDAP1 as one of the key regulators of longevity and aging. Mendelian randomization, colocalization, prospective studies, and in vitro experiments highlight PDAP1's effects on mortality, lifespan, and cellular senescence.
Tianzhichao Hou   +18 more
wiley   +1 more source

Expression of Cysteine Proteinases Cathepsins B and K and of Cysteine Proteinase Inhibitor Cystatin C in Giant Cell Tumor of Tendon Sheath [PDF]

open access: hybrid, 2001
Torsten Hansen   +6 more
openalex   +1 more source

The Lipidomic Profile Discriminates Between MASLD and MetALD

open access: yesAlimentary Pharmacology &Therapeutics, Volume 61, Issue 8, Page 1357-1371, April 2025.
HDL‐centric lipidomic biomarkers, particularly within large and medium HDL subfractions, distinguish metabolic dysfunction and alcohol‐related liver disease from metabolic dysfunction‐associated steatotic liver disease, suggesting potential biomarkers for clinical differentiation.
Kai Markus Schneider   +15 more
wiley   +1 more source

Reference Intervals for Plasma Cystatin C in Healthy Volunteers and Renal Patients, as Measured by the Dade Behring BN II System, and Correlation with Creatinine [PDF]

open access: bronze, 2001
Erik J. Uhlmann   +6 more
openalex   +1 more source

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