Results 121 to 130 of about 20,516 (271)

Hard‐Wired Solid‐State Bioelectronic Micropore Devices: Permanent Metal‐Protein‐Metal Junction Proof‐of‐Concept

Small, Volume 21, Issue 49, December 10, 2025.
A bottom‐up way to fabricate precisely engineered micropore solid‐state metal substrate/protein film / evaporated metal structures is shown to be a versatile platform for systematic electron transport measurements. As protein function is preserved and the junctions are thermally stable, down to 10K, such junctions can be useful for bioelectronic ...
Sudipta Bera, Eran Mishuk, Ping'an Li, Sourav Das, Sigal Keshet, Sharon Garusi, Leonid Tunik, Eran Edri, Yoram Selzer, Israel Pecht, Ayelet Vilan, Mordechai Sheves, David Cahen   +12 more
wiley   +1 more source

Nanodroplet‐Array‐Plattform zur integrierten Synthese und Screening von MEK Inhibitoren: Ein miniaturisierter Ansatz für die frühe Pharmaforschung

Angewandte Chemie, Volume 137, Issue 48, November 24, 2025.
Wir präsentieren eine Nanodroplet‐Array‐Plattform, die die Integration von Festphasensynthese, MALDI‐MS‐Analyse und zellbasiertem Screening von 325 potenziellen MEK‐Inhibitoren (Mitogen‐aktivierte‐Proteinkinase‐Kinase) in Nanoliter‐Volumina ermöglicht.
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Modification of Poly(5,6-epoxy-l-norleucine) Gives Functional Polypeptides with Alternative Side-Chain Linkages. [PDF]

, 2020
The preparation and characterization of a new epoxide containing polypeptide, poly(5,6-epoxy-l-norleucine), via postpolymerization modification of poly(l-homoallylglycine) is described.
Deming, Timothy J, Perlin, Pesach, Scott, Wendell A   +2 more
core  

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, Volume 64, Issue 48, November 24, 2025.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Radioprotective Efficacy of Cysteamine [PDF]

Acta Radiologica: Therapy, Physics, Biology, 1964
A, BOSE, S, BOSE, P, DE
openaire   +2 more sources

Comparison between the efficacy of cysteamine cream and combined hydroquinone cream in the treatment of melasma using skin analytical systems: An open-label quasi-randomized controlled trial in Asia patients

Dermatologica Sinica
Background: The mainstay of treatment for melasma is topical hydroquinone or preparations containing hydroquinone. In recent years, cysteamine cream has gained popularity in the treatment of hyperpigmentation disorders.
Andy Deng-Chi Chuang, Erh-Ti Lin, Chang-Cheng Chang, Yung-Hsueh Huang, Meng-En Lu, Chun-Fang Chuang, Hsiu-Mei Chiang   +6 more
doaj   +1 more source

Combined liver-kidney transplantation: Analysis of patients with preformed lymphocytotoxic antibody [PDF]

, 1988
In this report, we address combined liver-kidney transplantation, with particular attention to the apparent phenomenon of protection of kidney allografts to antibody mediated destruction by liver allografts.
Duquesnoy, R, Fung, J, Gordon, R, Griffin, M, Klintmalm, G, Makowka, L, Starzl, T, Todo, S, Tzakis, A   +8 more
core  

Dithiol Based on l-Cysteine and Cysteamine as a Disulfide-Reducing Agent [PDF]

, 2022
Francesca Bartoccini, Michele Retini, Rita Crinelli, Michele Menotta, Alessandra Fraternale, Giovanni Piersanti   +5 more
openalex   +1 more source

alpha -Lactalbumin (LA) Stimulates Milk beta-1,4-Galactosyltransferase I (beta 4Gal-T1) to Transfer Glucose from UDP-glucose to N-Acetylglucosamine: CRYSTAL STRUCTURE OF beta 4Gal-T1·LA COMPLEX WITH UDP-Glc* [PDF]

, 2001
beta-1,4-Galactosyltransferase 1 (Gal-T1) transfers galactose (Gal) from UDP-Gal to N-acetylglucosamine (GlcNAc), which constitutes its normal galactosyltransferase (Gal-T) activity.
Qasba, Pradman K., Ramakrishnan, Boopathy, Shah, Premal S.   +2 more
core  

Cysteamine Modulates Oxidative Stress and Blocks Myofibroblast Activity in CKD [PDF]

, 2013
Daryl M. Okamura, Nadia M. Bahrami, Shuyu Ren, Katie Pasichnyk, Juliana M. Williams, Jon A. Gangoiti, Jesús M. López-Guisa, Ikuyo Yamaguchi, Bruce A. Barshop, Jeremy S. Duffield, Allison A. Eddy   +10 more
openalex   +1 more source