Results 51 to 60 of about 8,396 (186)

Efficacy and safety of cysteamine-isobionicamide complex in postinflammatory hyperpigmentation: A 16-week, randomized, double-blinded, vehicle-controlled trial

Dermatologica Sinica, 2023
Background: Postinflammatory hyperpigmentation (PIH) is a prevalent acquired hyperpigmentation disorder with significant psychosocial implications. Cysteamine has demonstrated notable efficacy and safety in treating hyperpigmentation disorders.
Rosalie Tzu-Li Liu, Tsung-Fu Tsai, Yi-Jing Lai, Chau Yee Ng   +3 more
doaj   +1 more source

Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis

Frontiers in Immunology
ObjectiveCysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated.
Saeid Najafi-Fard, Chiara Farroni, Linda Petrone, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Valentina Vanini, Gilda Cuzzi, Tonino Alonzi, Emanuele Nicastri, Gina Gualano, Fabrizio Palmieri, Mauro Piacentini, Mauro Piacentini, Delia Goletti   +14 more
doaj   +1 more source

Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis

Orphanet Journal of Rare Diseases, 2022
Background Cystinosis is a rare autosomal recessive lysosomal storage disease, associated with high morbidity and mortality. Mutations in the CTNS gene disable a membrane protein responsible for the transport of cystine out of the lysosome.
Emma Hector, Donald Cairns, G. Michael Wall   +2 more
doaj   +1 more source

From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

Pharmaceuticals, 2023
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients.
Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kokot, Antun Koprivanac, Ivan Dobric, Marko Sever, Mario Staresinic, Lovorka Batelja Vuletic, Anita Skrtic, Sven Seiwerth   +24 more
doaj   +1 more source

Spectroscopic Investigation of Cysteamine Dioxygenase

Biochemistry, 2020
Thiol dioxygenases are mononuclear non-heme FeII-dependent metalloenzymes that initiate the oxidative catabolism of thiol-containing substrates to their respective sulfinates. Cysteine dioxygenase (CDO), the best characterized mammalian thiol dioxygenase, contains a three-histidine (3-His) coordination environment rather than the 2-His-1-carboxylate ...
Rebeca L. Fernandez, Stephanie L. Dillon, Martha H. Stipanuk, Brian G. Fox, Thomas C. Brunold   +4 more
openaire   +3 more sources

Simple Synthesis Method and Characterizations of Aggregation-Free Cysteamine Capped PbS Quantum Dot

Applied Sciences, 2019
Quantum dots have diverse chemical properties with different ligands attached on the surface. The cysteamine has been used as a ligand for various quantum dots because it has high solubility in water, and it facilitates binding of quantum dot and gold ...
Daekyung Kang, Mareddi Bharath Kumar, Changhee Son, Hongsik Park, Jonghoo Park   +4 more
doaj   +1 more source

Cysteamine exerts in vitro antiviral activity against the SARS-CoV-2 Delta and Omicron variants

Cell Death Discovery, 2022
The novel SARS-CoV-2 variants of concern (VOC) represent a considerable global alarm because their mutations are known to affect transmissibility and cause immune escape.
Tonino Alonzi, Alessandra Aiello, Federica Repele, Laura Falasca, Massimo Francalancia, Anna Rosa Garbuglia, Giovanni Delogu, Emanuele Nicastri, Mauro Piacentini, Delia Goletti   +9 more
doaj   +1 more source

Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems, Part II: Long-Term Stability and Clinical Ocular Biopermanence

Pharmaceutics, 2023
Background: Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in several tissues and organs causing, among others, severe eye symptoms.
Ana Castro-Balado, Andrea Cuartero-Martínez, Hugo Pena-Verdeal, Gonzalo Hermelo-Vidal, Anja Schmidt, Belén Montero, Manuela Hernández-Blanco, Irene Zarra-Ferro, Miguel González-Barcia, Cristina Mondelo-García, María Jesús Giráldez, Eva Yebra-Pimentel, Francisco J. Otero-Espinar, Anxo Fernández-Ferreiro   +13 more
doaj   +1 more source

Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology, 2021
Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less ...
Douglas J. Fraser-Pitt, Stephen K. Dolan, David Toledo-Aparicio, Jessica G. Hunt, Daniel W. Smith, Niamh Lacy-Roberts, Piumi Sara Nupe Hewage, Teodora N. Stoyanova, Erin Manson, Kevin McClean, Neil F. Inglis, Derry K. Mercer, Deborah A. O’Neil   +12 more
doaj   +1 more source

Thiol-SAM Concentration Effect on the Performance of Interdigitated Electrode-Based Redox-Free Biosensors

Micromachines
Despite the direct, redox-free and simple detection non-faradaic impedimetric biosensors offer, considerable optimizations are required to enhance their performance for the detection of various biomarkers. Non-faradaic EIS sensors’ performance depends on
Abdulaziz K. Assaifan
doaj   +1 more source