Cystamine preparations exhibit anticoagulant activity.
PLoS ONE, 2015 Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl)-lysyl crosslinks between proteins.
Maria M Aleman +5 more
doaj +4 more sources
Effect of Linear Energy Transfer on Cystamine’s Radioprotective Activity: A Study Using the Fricke Dosimeter with 6–500 MeV per Nucleon Carbon Ions—Implication for Carbon Ion Hadrontherapy [PDF]
Molecules, 2023 (1) Background: Radioprotective agents have garnered considerable interest due to their prospective applications in radiotherapy, public health medicine, and situations of large-scale accidental radiation exposure or impending radiological emergencies ...
Samafou Penabeï +4 more
doaj +2 more sources
Antioxidants, 2023 (1) Background: cystamine and its reduced form cysteamine have radioprotective/antioxidant effects in vivo. In this study, we use an in vitro model system to examine the behavior of cystamine towards the reactive primary species produced during the ...
Penabei Samafou +2 more
exaly +3 more sources
Modification of proteins by norepinephrine is important for vascular contraction [PDF]
Frontiers in Physiology, 2010 Norepinephrine (NE) is thought to mediate its effects through G-protein coupled receptors. However, previous studies have shown that norepinephrine and another primary amine, serotonin, also have the ability to exert effects in a receptor-independent ...
Kyle B Johnson +2 more
doaj +3 more sources
Cystamine reduces neurodegeneration and epileptogenesis following soman-induced status epilepticus in rats [PDF]
Experimental Biology and MedicineAcute exposure to a seizure-inducing dose of an organophosphorus nerve agent inhibits acetylcholinesterase, leading to pharmacoresistance if benzodiazepine treatment is delayed.
Abiel K. Biney +6 more
doaj +2 more sources
Inhibition of Low-Density Lipoprotein Oxidation by Cysteamine, Cystamine, Cysteine and Cystine at Lysosomal pH and pH 7.4 [PDF]
AntioxidantsLDL can be oxidised in the lysosomes of macrophages. Cysteamine, a thiol antioxidant that accumulates in lysosomes, inhibits the oxidation of LDL by iron at lysosomal pH (pH 4.5) and protects against atherosclerosis in mice.
Emily J. Parkes +8 more
doaj +2 more sources
Effect of Cystamine on Sperm and Antioxidant Parameters of Ram Semen Stored at 4 °C for 50 Hours [PDF]
Archives of Razi Institute, 2021 Physical and chemical changes caused by oxidative stress in the spermatozoa membrane can reduce spermatozoa function and even lead to death. Cystamine (NH2-CH2-CH2-SH, β-mercaptoethylamine) is a natural substance that modulates the endocrine and ...
J Jumintono +9 more
doaj +3 more sources
Molecular Hydrogen as an Antioxidant and Radioprotector: Mechanistic Insights from Monte Carlo Radiation-Chemical Simulations [PDF]
Antioxidants(1) Background: Water, comprising about 70–80% of cellular mass, is the most abundant constituent of living cells. Upon exposure to ionizing radiation, water undergoes radiolysis, generating a variety of reactive species, including free radicals and ...
Sumaiya Akhter Ria +2 more
doaj +2 more sources
Cystamine induces AIF-mediated apoptosis through glutathione depletion [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2001 Cystamine and its reduced form cysteamine showed protective effects in various models of neurodegenerative disease, including Huntington's disease and Parkinson's disease.
Cho, Sung-Yup +11 more
core +3 more sources
Impaired DNAJB2 Response to Heat Shock in Fibroblasts from a Neuropathy Patient with DNAJB2/HSJ1 Mutation: Cystamine as a Potential Therapeutic Intervention [PDF]
Neurology InternationalBackground and Objectives: Neuropathy is a debilitating disorder characterized by peripheral nerve dysfunction and damage to sensory, motor, and autonomic neurons and their axons.
Raj Kumar Pradhan +3 more
doaj +2 more sources