Results 1 to 10 of about 4,936 (212)
Antioxidants, 2023 (1) Background: cystamine and its reduced form cysteamine have radioprotective/antioxidant effects in vivo. In this study, we use an in vitro model system to examine the behavior of cystamine towards the reactive primary species produced during the ...
Jintana Meesungnoen +2 more
exaly +4 more sources
Dual-Stimuli Responsive Cystamine-Modified Polydopamine Coatings as Payload Gatekeepers [PDF]
MoleculesWe present cystamine-modified polydopamine (PDA) coatings as tunable gatekeepers for mesoporous silica nanoparticles (MSNs) in drug delivery. Unlike conventional post-functionalization strategies, cystamine moieties were incorporated directly into the ...
Sylwia Ostrowska +3 more
doaj +2 more sources
Cystamine reduces neurodegeneration and epileptogenesis following soman-induced status epilepticus in rats [PDF]
Experimental Biology and MedicineAcute exposure to a seizure-inducing dose of an organophosphorus nerve agent inhibits acetylcholinesterase, leading to pharmacoresistance if benzodiazepine treatment is delayed.
Abiel K. Biney +6 more
doaj +2 more sources
Inhibition of Low-Density Lipoprotein Oxidation by Cysteamine, Cystamine, Cysteine and Cystine at Lysosomal pH and pH 7.4 [PDF]
AntioxidantsLDL can be oxidised in the lysosomes of macrophages. Cysteamine, a thiol antioxidant that accumulates in lysosomes, inhibits the oxidation of LDL by iron at lysosomal pH (pH 4.5) and protects against atherosclerosis in mice.
Emily J. Parkes +8 more
doaj +2 more sources
Molecular Hydrogen as an Antioxidant and Radioprotector: Mechanistic Insights from Monte Carlo Radiation-Chemical Simulations [PDF]
Antioxidants(1) Background: Water, comprising about 70–80% of cellular mass, is the most abundant constituent of living cells. Upon exposure to ionizing radiation, water undergoes radiolysis, generating a variety of reactive species, including free radicals and ...
Sumaiya Akhter Ria +2 more
doaj +2 more sources
Impaired DNAJB2 Response to Heat Shock in Fibroblasts from a Neuropathy Patient with DNAJB2/HSJ1 Mutation: Cystamine as a Potential Therapeutic Intervention [PDF]
Neurology InternationalBackground and Objectives: Neuropathy is a debilitating disorder characterized by peripheral nerve dysfunction and damage to sensory, motor, and autonomic neurons and their axons.
Raj Kumar Pradhan +3 more
doaj +2 more sources
A Novel HDAC6 Inhibitor Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice [PDF]
MoleculesPsoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of keratinocytes and infiltration of inflammatory cells. Significant challenges remain in developing effective and safe targeted therapies for psoriasis.
Anqi Cao +6 more
doaj +2 more sources
Molecules, 2023 (1) Background: Radioprotective agents have garnered considerable interest due to their prospective applications in radiotherapy, public health medicine, and situations of large-scale accidental radiation exposure or impending radiological emergencies ...
Samafou Penabeï +4 more
doaj +1 more source
Cells, 2021 The ongoing pandemic of coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), needs better treatment options both at antiviral and anti-inflammatory levels.
Tonino Alonzi +13 more
doaj +1 more source
Frontiers in Immunology, 2020 Host-directed therapies (HDTs) are emerging as a potential valid support in the treatment of drug-resistant tuberculosis (TB). Following our recent report indicating that genetic and pharmacological inhibition of transglutaminase 2 (TG2) restricts ...
Ivana Palucci +21 more
doaj +1 more source