Sensors, 2020 This research demonstrated the development of a simple, cost-effective, and label-free immunosensor for the detection of α-synuclein (α-Syn) based on a cystamine (CYS) self-assembled monolayer (SAM) decorated fluorine-doped tin oxide (FTO ...
Chuang-Ye Ge +8 more
doaj +1 more source
CuI–Br Oligomers and Polymers Involving Cu–S(cystamine) Bonds [PDF]
, 2008 The syntheses, crystal structures, and thermal properties of five cuprous bromides derived from cystamine, [NH3(CH2)2SS(CH2)2NH3]2+, here denoted by (SS), are reported.
M. Kurmoo, N. Louvain, N. Mercier
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Neurobiology of Disease, 2010 Huntington's disease (HD) is a lethal, neurodegenerative disorder caused by expansion of the polyglutamine repeat in the Huntingtin gene (HTT), leading to mutant protein misfolding, aggregation, and neuronal death. Feeding a Drosophila HD model cystamine,
S.F. Bortvedt +4 more
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Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation [PDF]
, 2012 Molecular deletion of transglutaminase 2 (TG2) has been shown to improve function and survival in a host of neurological conditions including stroke, Huntington's disease, and Parkinson's disease. However, unifying schemes by which these cross-linking or
Antonyak, Marc A. +12 more
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Antibacterial Hydrogels Derived from Poly(γ-glutamic acid) Nanofibers
Gels, 2022 Biocompatible hydrogels with antibacterial properties derived from γ-polyglutamic acid (γ-PGA) were prepared from bulk and electrospun nanofibers.
Hamidreza Kasbiyan +5 more
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Construction of a Tethered Poly(ethylene glycol) Surface Gradient For Studies of Cell Adhesion Kinetics [PDF]
, 2005 Surface gradients can be used to perform a wide range of functions and represent a novel experimental platform for combinatorial discovery and analysis.
Fernandez, E. +5 more
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Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease [PDF]
, 2010 Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial biogenesis.
Antonyak, Marc A. +6 more
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Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations
Angewandte Chemie, EarlyView.The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach +4 more
wiley +2 more sources
Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation
Materials Today Bio, 2022 Chronic wounds and the accompanying inflammation are ongoing challenges in clinical treatment. They are usually accompanied by low pH and high oxidative stress environments, limiting cell growth and proliferation.
Bingyang Lu +9 more
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Synthesis of diacylated γ-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine [PDF]
, 2015 To overcome the major disadvantages of cysteamine, the only registered treatment for the rare genetic disease cystinosis, nine prodrugs of γ-glutamyl-cysteamine (4) were synthesized for evaluation.
Anderson, Rosaleen +5 more
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