Results 51 to 60 of about 7,096 (220)
Advanced Materials, EarlyView.Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno +15 more
wiley +1 more source
Thiosulfoxide (Sulfane) Sulfur: New Chemistry and New Regulatory Roles in Biology
Molecules, 2014 The understanding of sulfur bonding is undergoing change. Old theories on hypervalency of sulfur and the nature of the chalcogen-chalcogen bond are now questioned.
John I. Toohey, Arthur J. L. Cooper
doaj +1 more source
The extreme hyper-reactivity of Cys94 in lysozyme avoids its amorphous aggregation [PDF]
, 2018 Many proteins provided with disulfde bridges in the native state undergo amorphous irreversible aggregation when these bonds are not formed. Here we show that egg lysozyme displays a clever strategy to prevent this deleterious aggregation during the ...
Bocedi, Alessio +6 more
core +2 more sources
Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
A colourimetric method for the determination of the degree of chemical cross-linking in aspartic acid-based polymer gels. [PDF]
, 2015 A 2,4,6-trinitrobenzenesulphonic acid (TNBS)-based assay is developed to determine the degree of chemical cross-linking in aspartic acid-based polymer gels.
Gyarmati, Benjámin +3 more
core +2 more sources
Millimeter‐Scale Dual‐Opposing RNA‐Gradient Hydrogel for Interfacial Gene Silencing
Advanced Science, EarlyView.A branched microfluidic platform enables the fabrication of millimeter‐scale hydrogels with dual‐opposing RNA‐gradients for precise spatial control of cell gene expression. This device allows for the generation of multiple constructs at once, offering potential for future engineering of complex tissue interfaces with improved physiological relevance ...
Tyler Hoffman +11 more
wiley +1 more source
The elemental mechanism of transcriptional pausing. [PDF]
, 2019 Transcriptional pausing underlies regulation of cellular RNA biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longer-lived pauses can arise.
Chua, Xien Yu +6 more
core +1 more source
Bcr is a substrate for Transglutaminase 2 cross-linking activity [PDF]
, 2011 Background Breakpoint cluster region (Bcr) is a multi-domain protein that contains a C-terminal GTPase activating protein (GAP) domain for Rac. Transglutaminase 2 (TG2) regulates Bcr by direct binding to its GAP domain.
Sun-Ju Yi +2 more
core +1 more source
Advanced NanoBiomed Research, EarlyView.Bowl‐shaped Janus nanomotors with platinum, iron oxide, and polypyrrole integrate catalytic, magnetic, and electric propulsion for targeted drug delivery. They demonstrate controlled, directional motion under varying pH and hydrogen peroxide conditions, with optimal performance in neutral media.
Kimia Tavakoli Dehaghi +3 more
wiley +1 more source
Serotonylation of vascular proteins important to contraction. [PDF]
PLoS ONE, 2009 BACKGROUND:Serotonin (5-hydroxytryptamine, 5-HT) was named for its source (sero-) and ability to modify smooth muscle tone (tonin). The biological effects of 5-HT are believed to be carried out by stimulation of serotonin receptors at the plasma membrane.
Stephanie W Watts +2 more
doaj +1 more source