Results 41 to 50 of about 6,537 (217)

Modification of proteins by norepinephrine is important for vascular contraction

Frontiers in Physiology, 2010
Norepinephrine (NE) is thought to mediate its effects through G-protein coupled receptors. However, previous studies have shown that norepinephrine and another primary amine, serotonin, also have the ability to exert effects in a receptor-independent ...
Kyle B Johnson, Janice M Thompson, Stephanie W Watts   +2 more
doaj   +1 more source

Prostate-specific membrane antigen targeted, glutathione-sensitive nanoparticles loaded with docetaxel and enzalutamide for the delivery to prostate cancer

Drug Delivery, 2022
Prostate cancer (PCa) is the most common malignant tumor in men. Chemotherapy with docetaxel (DTX) and novel hormonal agents such as enzalutamide (EZL) and abiraterone are the preferred first-line therapeutic regimens. Prostate-specific membrane antigen (
Yang Chen, Zhenyu Xu, Tingxun Lu, Jia Luo, Hua Xue   +4 more
doaj   +1 more source

Dual-Stimuli Responsive Cystamine-Modified Polydopamine Coatings as Payload Gatekeepers

Molecules
We present cystamine-modified polydopamine (PDA) coatings as tunable gatekeepers for mesoporous silica nanoparticles (MSNs) in drug delivery. Unlike conventional post-functionalization strategies, cystamine moieties were incorporated directly into the ...
Sylwia Ostrowska, Monika Szukowska, Yeonho Kim, Radosław Mrówczyński   +3 more
doaj   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source

Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo

Bioscience Reports, 2018
Cystamine is commonly used as a transglutaminase inhibitor. This disulphide undergoes reduction in vivo to the aminothiol compound, cysteamine. Thus, the mechanism by which cystamine inhibits transglutaminase activity in vivo could be due to either ...
T. Jeitner, J. Pinto, Arthur J. L. Cooper   +2 more
semanticscholar   +1 more source

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

Advanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li, Xinchun Zhang   +5 more
wiley   +1 more source

Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

Beilstein Journal of Nanotechnology, 2019
Polymer hydrogels are ideal scaffolds for both tissue engineering and drug delivery. A great advantage of poly(amino acid)-based hydrogels is their high similarity to natural proteins. However, their expensive and complicated synthesis often limits their
Dávid Juriga, Evelin Sipos, Orsolya Hegedűs, Gábor Varga, Miklós Zrínyi, Krisztina S. Nagy, Angéla Jedlovszky-Hajdú   +6 more
doaj   +1 more source

Multi‐Responsive Bowl‐Shaped Janus Nanomotors Based on Polyitaconic acid/Polypyrrole on the Surface of Iron Oxide Nanoparticles with Chemical, Electrical, and Magnetic Field Actuation for Targeted Drug Delivery Applications

Advanced NanoBiomed Research, EarlyView.
Bowl‐shaped Janus nanomotors with platinum, iron oxide, and polypyrrole integrate catalytic, magnetic, and electric propulsion for targeted drug delivery. They demonstrate controlled, directional motion under varying pH and hydrogen peroxide conditions, with optimal performance in neutral media.
Kimia Tavakoli Dehaghi, Sepideh Khoee, Shima Tavakoli, Oommen P. Varghese   +3 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Thiosulfoxide (Sulfane) Sulfur: New Chemistry and New Regulatory Roles in Biology

Molecules, 2014
The understanding of sulfur bonding is undergoing change. Old theories on hypervalency of sulfur and the nature of the chalcogen-chalcogen bond are now questioned.
John I. Toohey, Arthur J. L. Cooper
doaj   +1 more source