Results 41 to 50 of about 4,936 (212)

Modification of proteins by norepinephrine is important for vascular contraction

Frontiers in Physiology, 2010
Norepinephrine (NE) is thought to mediate its effects through G-protein coupled receptors. However, previous studies have shown that norepinephrine and another primary amine, serotonin, also have the ability to exert effects in a receptor-independent ...
Kyle B Johnson, Janice M Thompson, Stephanie W Watts   +2 more
doaj   +1 more source

Prostate-specific membrane antigen targeted, glutathione-sensitive nanoparticles loaded with docetaxel and enzalutamide for the delivery to prostate cancer

Drug Delivery, 2022
Prostate cancer (PCa) is the most common malignant tumor in men. Chemotherapy with docetaxel (DTX) and novel hormonal agents such as enzalutamide (EZL) and abiraterone are the preferred first-line therapeutic regimens. Prostate-specific membrane antigen (
Yang Chen, Zhenyu Xu, Tingxun Lu, Jia Luo, Hua Xue   +4 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Enzymatic Electrosynthesis for Sustainable CO2 Conversion: Advancing Circular Carbon Economy

Carbon Energy, EarlyView.
Enzymatic electrosynthesis (EES) offers molecular precision in synthesizing value‐added products from CO2. We highlight its distinct edge over alternative enzyme‐hybrid systems and analyze electron transfer pathways. Key strategies to overcome electron transfer bottlenecks and expand product diversity are addressed, and also data‐driven approaches for ...
Yan Xie, Jia Ouyang, Manu Suvarna, Xiangzhou Yuan, Matthew R. Hill, Uwe Bornscheuer, Huiyan Zhang, Yong Sik Ok   +7 more
wiley   +1 more source

Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

Beilstein Journal of Nanotechnology, 2019
Polymer hydrogels are ideal scaffolds for both tissue engineering and drug delivery. A great advantage of poly(amino acid)-based hydrogels is their high similarity to natural proteins. However, their expensive and complicated synthesis often limits their
Dávid Juriga, Evelin Sipos, Orsolya Hegedűs, Gábor Varga, Miklós Zrínyi, Krisztina S. Nagy, Angéla Jedlovszky-Hajdú   +6 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Thiosulfoxide (Sulfane) Sulfur: New Chemistry and New Regulatory Roles in Biology

Molecules, 2014
The understanding of sulfur bonding is undergoing change. Old theories on hypervalency of sulfur and the nature of the chalcogen-chalcogen bond are now questioned.
John I. Toohey, Arthur J. L. Cooper
doaj   +1 more source

Bio‐Based Transparent Self‐Healable Polyimides Enabled by Isosorbide‐Derived Dianhydride Design and Aliphatic Chain‐Mobility Regulation

Small, EarlyView.
Transparency, toughness, and self‐healing rarely coexist within a single polyimide. This bio‐based aliphatic–aromatic film resolves that conflict. An isosorbide‐derived dianhydride and a fatty diamine cooperatively suppress charge‐transfer complexes, yielding a colorless film that heals rapidly under mild heat, retains its toughness, and restores ...
Jisu Jang, Woojin Kang, Yeongseok Seo, Gyu Hyoung Bae, Jeong Yeon Yoo, Sang Goo Lee, Keun‐Hwan Oh, Hong Suk Kang   +7 more
wiley   +1 more source

Cystamine inhibits fibrin crosslinking.

, 2015
Representative western blots and densitometry analysis showing the effects of cystamine (A, B) and T101 (C, D) on fibrin formation and crosslinking.
Maria M. Aleman (730511), Christa I. Devette (730513), Lori A. Holle (730512), Dougald M. Monroe (730514), Katherine G. Stember (647428), Alisa S. Wolberg (695929)   +5 more
core   +1 more source

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase [PDF]

, 2006
There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine is a candidate drug; however, the mechanisms by which it operates remain unclear.
Humbert, Sandrine, Cheetham, Michael E., Hirsch, Etienne, Cordelières, Fabrice P., Pineda Martí, José Ramón, Borrell Pagès, Maria, Brouillet, Emmanuel, Saudou, Frédéric, Parker, J. Alex, Hantraye, Philippe, Néri, Christian, Grange, Ghislaine, Guillermier, Martine, Bryson, Elzbieta A., Canals i Coll, Josep M., Alberch i Vié, Jordi, 1959-   +15 more
core   +1 more source