Results 21 to 30 of about 7,096 (220)

Synthesis and biodistribution of immunoconjugates of a human IgM and polymeric drug carriers [PDF]

, 1992
The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody directed against an intracellular tumour-associated antigen and either poly (alpha-L-glutamic acid) (PGA) or poly[N5-(2-hydroxyethyl)-L ...
Anderson, James M., Boon, P.J., Bos, E.S., Feijen, J., Grootoonk, J., Hoes, C.J.T., Kaspersen, F., Loeffen, P., Schlachter, I., Winters, M.   +9 more
core   +2 more sources

Albumin nanoparticles for glutathione-responsive release of cisplatin: new opportunities for medulloblastoma treatment [PDF]

, 2016
Redox-responsive nanoparticles were synthesized by desolvation of bovine serum albumin followed by disulfide-bond crosslinking with N, Nʹ-Bis (acryloyl) cystamine. Dynamic light scattering and transmission electron microscopy studies revealed spherical
Abballe, Luana, Besharat, ZEIN MERSINI, Catanzaro, Giuseppina, Cirillo, Giuseppe, Curcio, Manuela, Ferretti, Elisabetta, Iemma, Francesca, Picci, Nevio, Spizzirri, Umile Gianfranco, Vacca, Alessandra   +9 more
core   +1 more source

Facile synthesis of redox-responsive paclitaxel drug release platform using metal-organic frameworks (ZIF-8) for gastric cancer treatment

Materials Research Express, 2020
This paper investigated the dual-role of cystamine as a surface modification linker and stimuli-responsive material, and simplify redox-responsive drug delivery system synthesis.
Aiqing Ma, Rui Zhang
doaj   +1 more source

Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation

Pharmaceutics, 2020
Cystamine-based polymers may help to achieve controlled and targeted drug delivery to the colon due to their susceptibility to breakage of the disulfide linkage in the low redox potential environment of the colon.
Yoke Mooi Ng, Siti Nur Aishah Mat Yusuf, Hock Ing Chiu, Vuanghao Lim   +3 more
doaj   +1 more source

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation [PDF]

, 2014
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures
Amin R, Andrea Venerando, Angela Sepe, Anil Mehta, Anna Bossi, Anna Zolin, Antonella Tosco, Boyle MP BS, Carlo A Leone, Daniela De Stefano, Donaldson S., Fabiola De Gregorio, Fischer H, Gianni Bona, Gibson LE, Giuseppe De Rosa, Guido Kroemer, Illek B, Jayaraman S, Kerem B, Kerem Eithan HMO, Laura Salvadori, Legssyer R, Lorenzo A Pinna, Luigi Maiuri, Lukacs G, Maria C Maiuri, Massimo Pettoello-Mantovani, Masvidal L, Pharmaceuticals Cylene, Pharmaceuticals Cylene, Rosa Grassia, Speranza Esposito, Standardization of Spirometry, Stefano Guido, Stern M, Valeria R Villella, Valeria Raia, van Doorninck JH, Villella VR   +39 more
core   +4 more sources

Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson's disease

Neurobiology of Disease, 2015
The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical trials in Huntington's disease, showing tolerability and benefits on motor symptoms.
G. Cisbani, J. Drouin-Ouellet, C. Gibrat, M. Saint-Pierre, M. Lagacé, S. Badrinarayanan, M.H. Lavallée-Bourget, J. Charest, A. Chabrat, L. Boivin, M. Lebel, M. Bousquet, M. Lévesque, F. Cicchetti   +13 more
doaj   +1 more source

Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases

Frontiers in Neurology, 2019
Current medications for neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), and Schizophrenia mainly target disease symptoms.
Bindu D. Paul, Solomon H. Snyder, Solomon H. Snyder, Solomon H. Snyder   +3 more
doaj   +1 more source

Synthesis and Characterization of Healable Waterborne Polyurethanes with Cystamine Chain Extenders

Molecules, 2019
In this study, environmentally friendly, self-healing waterborne polyurethanes (WPUs) were prepared based on the disulfide metathesis reaction in cystamine.
Dae-Il Lee, Seung-Hyun Kim, Dai-Soo Lee
doaj   +1 more source

Cysteamine as a novel disease-modifying compound for Parkinson's disease: Over a decade of research supporting a clinical trial

Neurobiology of Disease, 2019
To date, medical and surgical interventions offered to patients with Parkinson's disease (PD) serve only to manage clinical symptoms; they have not shown the capacity to halt nor reverse degenerative processes.
F. Cicchetti, L.S. David, A. Siddu, H.L. Denis   +3 more
doaj   +1 more source

Construction of Cell-Resistant Surfaces by Immobilization of Poly(ethylene glycol) on Gold [PDF]

, 2004
Considerable effort has been expended in efforts to create surfaces that resist the adsorption of proteins and cells for biomedical applications. The majority of such work has focused on surfaces constructed from bulk polymers or thin polymer films ...
Fernandez, E., Hillier, Andrew, Hillier, Andrew, Lawrence, M., Mougin, K.   +4 more
core   +3 more sources