Results 11 to 20 of about 3,558 (177)

Cystamine preparations exhibit anticoagulant activity.

PLoS ONE, 2015
Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl)-lysyl crosslinks between proteins.
Maria M Aleman, Lori A Holle, Katherine G Stember, Christa I Devette, Dougald M Monroe, Alisa S Wolberg   +5 more
doaj   +4 more sources

Inhibition of Transglutaminase 2 as a Potential Host-Directed Therapy Against Mycobacterium tuberculosis

Frontiers in Immunology, 2020
Host-directed therapies (HDTs) are emerging as a potential valid support in the treatment of drug-resistant tuberculosis (TB). Following our recent report indicating that genetic and pharmacological inhibition of transglutaminase 2 (TG2) restricts ...
Ivana Palucci, Ivana Palucci, Giuseppe Maulucci, Giuseppe Maulucci, Flavio De Maio, Flavio De Maio, Michela Sali, Michela Sali, Alessandra Romagnoli, Linda Petrone, Gian Maria Fimia, Gian Maria Fimia, Maurizio Sanguinetti, Maurizio Sanguinetti, Delia Goletti, Marco De Spirito, Marco De Spirito, Mauro Piacentini, Mauro Piacentini, Giovanni Delogu, Giovanni Delogu, Giovanni Delogu   +21 more
doaj   +1 more source

N,N-Bis(7-nitrobenz[c][1,2,5]oxadiazol-4-yl)cystamine

Molbank, 2022
Background: New amino derivatives of NBD type are of high interest due to their strong fluorescence, while compounds containing a disulphide moiety are of high interest in nano-chemistry due to their easiness of attaching to noble nanoparticles ...
Iulia Matei, Dana C. Culita, Victorita Tecuceanu, Anamaria Hanganu, Petre Ionita   +4 more
doaj   +1 more source

Inhibiting Transglutaminase 2 Mediates Kidney Fibrosis via Anti-Apoptosis

Biomedicines, 2022
Transglutaminase 2 (TG2) is a calcium-dependent transamidating acyltransferase enzyme of the protein-glutamine γ-glutamyltransferase family implicated in kidney injury. In this study, we identified associations between TG2 and chronic kidney disease (CKD)
Jong-Joo Moon, Yejin Choi, Kyu-Hyeon Kim, Areum Seo, Soie Kwon, Yong-Chul Kim, Dong-Ki Kim, Yon-Su Kim, Seung-Hee Yang   +8 more
doaj   +1 more source

Effect of Cystamine on Sperm and Antioxidant Parameters of Ram Semen Stored at 4 °C for 50 Hours [PDF]

Archives of Razi Institute, 2021
Physical and chemical changes caused by oxidative stress in the spermatozoa membrane can reduce spermatozoa function and even lead to death. Cystamine (NH2-CH2-CH2-SH, β-mercaptoethylamine) is a natural substance that modulates the endocrine and ...
J Jumintono, S Alkubaisy, D Yánez Silva, K Singh, A Turki Jalil, S Mutia Syarifah, Y Fakri Mustafa, I Mikolaychik, L Morozova, M Derkho   +9 more
doaj   +1 more source

Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials, 2021
Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs.
Manuela Curcio, Alessandro Paolì, Giuseppe Cirillo, Sebastiano Di Pietro, Martina Forestiero, Francesca Giordano, Loredana Mauro, Diana Amantea, Valeria Di Bussolo, Fiore Pasquale Nicoletta, Francesca Iemma   +10 more
doaj   +1 more source

Facile synthesis of redox-responsive paclitaxel drug release platform using metal-organic frameworks (ZIF-8) for gastric cancer treatment

Materials Research Express, 2020
This paper investigated the dual-role of cystamine as a surface modification linker and stimuli-responsive material, and simplify redox-responsive drug delivery system synthesis.
Aiqing Ma, Rui Zhang
doaj   +1 more source

Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation

Pharmaceutics, 2020
Cystamine-based polymers may help to achieve controlled and targeted drug delivery to the colon due to their susceptibility to breakage of the disulfide linkage in the low redox potential environment of the colon.
Yoke Mooi Ng, Siti Nur Aishah Mat Yusuf, Hock Ing Chiu, Vuanghao Lim   +3 more
doaj   +1 more source

Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson's disease

Neurobiology of Disease, 2015
The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical trials in Huntington's disease, showing tolerability and benefits on motor symptoms.
G. Cisbani, J. Drouin-Ouellet, C. Gibrat, M. Saint-Pierre, M. Lagacé, S. Badrinarayanan, M.H. Lavallée-Bourget, J. Charest, A. Chabrat, L. Boivin, M. Lebel, M. Bousquet, M. Lévesque, F. Cicchetti   +13 more
doaj   +1 more source

Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases

Frontiers in Neurology, 2019
Current medications for neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), and Schizophrenia mainly target disease symptoms.
Bindu D. Paul, Solomon H. Snyder, Solomon H. Snyder, Solomon H. Snyder   +3 more
doaj   +1 more source