Results 11 to 20 of about 7,096 (220)

Redox-responsive alginate microsphere containing cystamine

Journal of Biomaterials Science, Polymer Edition, 2016
Redox-responsive microspheres were prepared by solidifying the alginate- and cystamine-containing water droplets of O/W emulsion using calcium ion. Emulsions were prepared using alginate/cystamine mixture solution whose the carboxylic group/the amino group molar ratio was 1:1, 1:2, and 1:3, and whose the total concentration was kept to 2% (w/v).
Kyeongnan, Kwon, Jin-Chul, Kim
exaly   +3 more sources

New Ibuprofen Cystamine Salts With Improved Solubility and Anti‐Inflammatory Effect [PDF]

ChemistryOpen
Two novel ibuprofen cystamine salts (IBU‐CYS 1 and IBU‐CYS 2) are synthesized by coupling the anion of ibuprofen with cystamine dihydrochloride in 1 : 1 and 2 : 1 ratio to improve the solubility and bioavailability of ibuprofen.
Simay Denizkusu, Ece Sabuncu, Hande Sipahi, Prof. Duygu Avci   +3 more
doaj   +2 more sources

A Novel HDAC6 Inhibitor Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice [PDF]

Molecules
Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of keratinocytes and infiltration of inflammatory cells. Significant challenges remain in developing effective and safe targeted therapies for psoriasis.
Anqi Cao, Yurong Li, Yanqiao Feng, Xiaoquan Wang, Wenyu Wei, Hongyan Sun, Junmin Quan   +6 more
doaj   +2 more sources

Inhibition of Transglutaminase 2 Preserves Blood-Brain Barrier Integrity and Improves Neurological Outcomes After Experimental Traumatic Brain Injury in Mice. [PDF]

CNS Neurosci Ther
The article unraveled that inhibition or knockdown of TGM2 can restore blood–brain barrier (BBB) permeability and ameliorate neurological deficits and cognitive dysfunction in a mouse model of traumatic brain injury (TBI). Mechanistically, TGM2 likely modulates the IL‐17 signaling pathway to regulate MMP9 expression, thereby affecting BBB permeability.
Yang J, Zhang L, Qiu X, Wang J, Yan R, Ye J, Peng J, Jiang Y.   +7 more
europepmc   +2 more sources

Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy

Cells, 2021
The ongoing pandemic of coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), needs better treatment options both at antiviral and anti-inflammatory levels.
Tonino Alonzi, Alessandra Aiello, Linda Petrone, Saeid Najafi Fard, Manuela D’Eletto, Laura Falasca, Roberta Nardacci, Federica Rossin, Giovanni Delogu, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Mauro Piacentini, Delia Goletti   +13 more
doaj   +1 more source

Inhibition of Transglutaminase 2 as a Potential Host-Directed Therapy Against Mycobacterium tuberculosis

Frontiers in Immunology, 2020
Host-directed therapies (HDTs) are emerging as a potential valid support in the treatment of drug-resistant tuberculosis (TB). Following our recent report indicating that genetic and pharmacological inhibition of transglutaminase 2 (TG2) restricts ...
Ivana Palucci, Ivana Palucci, Giuseppe Maulucci, Giuseppe Maulucci, Flavio De Maio, Flavio De Maio, Michela Sali, Michela Sali, Alessandra Romagnoli, Linda Petrone, Gian Maria Fimia, Gian Maria Fimia, Maurizio Sanguinetti, Maurizio Sanguinetti, Delia Goletti, Marco De Spirito, Marco De Spirito, Mauro Piacentini, Mauro Piacentini, Giovanni Delogu, Giovanni Delogu, Giovanni Delogu   +21 more
doaj   +1 more source

N,N-Bis(7-nitrobenz[c][1,2,5]oxadiazol-4-yl)cystamine

Molbank, 2022
Background: New amino derivatives of NBD type are of high interest due to their strong fluorescence, while compounds containing a disulphide moiety are of high interest in nano-chemistry due to their easiness of attaching to noble nanoparticles ...
Iulia Matei, Dana C. Culita, Victorita Tecuceanu, Anamaria Hanganu, Petre Ionita   +4 more
doaj   +1 more source

A Dual Stimuli Responsive Supramolecular Gel Provides Insulin Hydrolysis Protection and Redox-Controlled Release of Actives [PDF]

, 2020
Two supramolecular hydrogelators containing a central disulfide moiety and terminal carboxylic acid groups are studied. On the one hand, the hydrogels are responsive to a reductive environment, which transforms the disulfide unit to the corresponding ...
Angulo-Pachón, César A., Bedrina, Begoña, Galindo, Francisco, Miravet, Juan, Navarro Barreda, Diego   +4 more
core   +1 more source

Inhibiting Transglutaminase 2 Mediates Kidney Fibrosis via Anti-Apoptosis

Biomedicines, 2022
Transglutaminase 2 (TG2) is a calcium-dependent transamidating acyltransferase enzyme of the protein-glutamine γ-glutamyltransferase family implicated in kidney injury. In this study, we identified associations between TG2 and chronic kidney disease (CKD)
Jong-Joo Moon, Yejin Choi, Kyu-Hyeon Kim, Areum Seo, Soie Kwon, Yong-Chul Kim, Dong-Ki Kim, Yon-Su Kim, Seung-Hee Yang   +8 more
doaj   +1 more source

Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials, 2021
Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs.
Manuela Curcio, Alessandro Paolì, Giuseppe Cirillo, Sebastiano Di Pietro, Martina Forestiero, Francesca Giordano, Loredana Mauro, Diana Amantea, Valeria Di Bussolo, Fiore Pasquale Nicoletta, Francesca Iemma   +10 more
doaj   +1 more source