Results 1 to 10 of about 24,457 (113)

Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study. [PDF]

Matrix Biol Plus
Background: Glaucoma is a leading cause of blindness characterized by progressive degeneration of the optic nerve. Elevated intraocular pressure, typically associated with glaucoma, exerts biomechanical strain on the optic nerve head, where ...
Rangan RS, Kapic A, do Valle R, Lam C, Patel PD, Pham JH, Raphi R, Prokai L, Tovar-Vidales T, Clark AF.   +9 more
europepmc   +2 more sources

Transglutaminase 2 in human peritoneal dialysis-related peritoneal injury. [PDF]

Physiol Rep
Patients undergoing long‐term peritoneal dialysis (PD) frequently develop peritoneal fibrosis and angiogenesis, leading to membrane dysfunction. Transglutaminase 2 (TG2) stabilizes the extracellular matrix against proteases.
Kunoki S, Ikeno M, Tatsukawa H, Sakai Y, Kinashi H, Kamiya K, Suzuki M, Mizuno M, Yamaguchi M, Sasakura H, Morioka Y, Banshodani M, Tawada M, Iwabu M, Ishimoto T, Takeuchi K, Hitomi K, Kawanishi H, Ito Y.   +18 more
europepmc   +2 more sources

Transglutaminase 2 function in glioblastoma tumor efferocytosis. [PDF]

Cell Death Dis
Glioblastoma is an aggressive and incurable type of brain cancer. Regions of tissue necrosis are a distinctive pathological feature of this cancer. These arise through thrombosis of tumor vasculature, driven by tumor-derived pro-coagulation factors.
Lui M, Sevinc F, Elgafarawi M, Munoz DG, Keillor JW, Sinclair J, Catana D, Alhuthayl M, Woulfe J, Lorimer IA.   +9 more
europepmc   +2 more sources

p38α MAPK-Mediated Redox Regulation of Transglutaminase 2 Drives Microvascular Leakage in Diabetic Retinas. [PDF]

Antioxidants (Basel)
Microvascular leakage is an early hallmark of diabetic retinopathy (DR), but the redox-dependent mechanisms underlying this dysfunction remain unclear. Here, we investigated whether p38α mitogen-activated protein kinase (MAPK) activates transglutaminase ...
Koh TY, Lee AJ, Moon CH, Cho WR, Yoon JS, Kim M, Ha KS.   +6 more
europepmc   +2 more sources

Transglutaminase 2 in breast cancer metastasis and drug resistance. [PDF]

Front Cell Dev Biol
Transglutaminase 2 (TG2) is a widely distributed multifunctional protein with various enzymatic and non-enzymatic activities. It is becoming increasingly evident that high levels of TG2 in tumors induce the occurrence of epithelial to mesenchymal ...
Li M, Wang X, Hong J, Mao J, Chen J, Chen X, Du Y, Song D.   +7 more
europepmc   +2 more sources

Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance. [PDF]

Discov Oncol
Radiotherapy remains the cornerstone of treatment for glioblastoma (GBM). However, the frequent occurrence of radiation resistance presents a significant therapeutic challenge. A comprehensive understanding of the mechanisms underlying this resistance is
Sun C, Du Z, Yang W, Wang Q.
europepmc   +2 more sources

Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment. [PDF]

Front Immunol
IntroductionOvarian cancer is the most lethal gynecological malignancy. Deepening our knowledge of the interactions within the tumor microenvironment (TME) is important for discovering new targeted treatment strategies.
Ibrahim D, Grondin M, Galpin K, Asif S, Thompson E, Nersesian S, Abou-Hamad J, Echaibi M, Rodriguez GM, Navals P, Macdonald E, Ryan B, Cook DP, Keillor JW, Vanderhyden BC.   +14 more
europepmc   +2 more sources

Inhibiting Transglutaminase 2 Mediates Kidney Fibrosis via Anti-Apoptosis

Biomedicines, 2022
Transglutaminase 2 (TG2) is a calcium-dependent transamidating acyltransferase enzyme of the protein-glutamine γ-glutamyltransferase family implicated in kidney injury. In this study, we identified associations between TG2 and chronic kidney disease (CKD)
Jong-Joo Moon, Yejin Choi, Kyu-Hyeon Kim, Areum Seo, Soie Kwon, Yong-Chul Kim, Dong-Ki Kim, Yon-Su Kim, Seung-Hee Yang   +8 more
doaj   +1 more source

Transglutaminase 2 programs differentiating acute promyelocytic leukemia cells in all-trans retinoic acid treatment to inflammatory stage through NF-κB activation

Haematologica, 2019
Differentiation syndrome (DS) is a life-threatening complication arising during retinoid treatment of acute promyelocytic leukemia (APL). Administration of all-trans retinoic acid leads to significant changes in gene expression, among the most induced of
Károly Jambrovics, Iván P. Uray, Zsolt Keresztessy, Jeffrey W. Keillor, László Fésüs, Zoltán Balajthy   +5 more
doaj   +1 more source

Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease

Frontiers in Immunology, 2021
Several environmental, genetic, and immune factors create a “perfect storm” for the development of coeliac disease: the antigen gluten, the strong association of coeliac disease with HLA, the deamidation of gluten peptides by the enzyme transglutaminase ...
Jordan Voisine, Jordan Voisine, Valérie Abadie, Valérie Abadie   +3 more
doaj   +1 more source