Results 1 to 10 of about 23,451 (112)

Transglutaminase 2 in human peritoneal dialysis‐related peritoneal injury [PDF]

Physiological Reports
Patients undergoing long‐term peritoneal dialysis (PD) frequently develop peritoneal fibrosis and angiogenesis, leading to membrane dysfunction. Transglutaminase 2 (TG2) stabilizes the extracellular matrix against proteases.
Shunnosuke Kunoki, Masashi Ikeno, Hideki Tatsukawa, Yukinao Sakai, Hiroshi Kinashi, Keisuke Kamiya, Masafumi Suzuki, Masashi Mizuno, Makoto Yamaguchi, Hiroyuki Sasakura, Yuki Morioka, Masataka Banshodani, Mitsuhiro Tawada, Masato Iwabu, Takuji Ishimoto, Kosei Takeuchi, Kiyotaka Hitomi, Hideki Kawanishi, Yasuhiko Ito   +18 more
doaj   +2 more sources

Transglutaminase 2 function in glioblastoma tumor efferocytosis [PDF]

Cell Death and Disease
Glioblastoma is an aggressive and incurable type of brain cancer. Regions of tissue necrosis are a distinctive pathological feature of this cancer. These arise through thrombosis of tumor vasculature, driven by tumor-derived pro-coagulation factors.
Margarita Lui, Filiz Sevinc, Mara Elgafarawi, David G. Munoz, Jeffrey W. Keillor, John Sinclair, Dragosh Catana, Meshari Alhuthayl, John Woulfe, Ian AJ Lorimer   +9 more
doaj   +2 more sources

Transglutaminase 2 in breast cancer metastasis and drug resistance [PDF]

Frontiers in Cell and Developmental Biology
Transglutaminase 2 (TG2) is a widely distributed multifunctional protein with various enzymatic and non-enzymatic activities. It is becoming increasingly evident that high levels of TG2 in tumors induce the occurrence of epithelial to mesenchymal ...
Mengxin Li, Xuanzhong Wang, Jinghui Hong, Juanjuan Mao, Jiasi Chen, Xuyang Chen, Ye Du, Dong Song   +7 more
doaj   +2 more sources

Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance [PDF]

Discover Oncology
Radiotherapy remains the cornerstone of treatment for glioblastoma (GBM). However, the frequent occurrence of radiation resistance presents a significant therapeutic challenge. A comprehensive understanding of the mechanisms underlying this resistance is
Cuiping Sun, Zhiyong Du, Wenhui Yang, Qing Wang   +3 more
doaj   +2 more sources

p38α MAPK-Mediated Redox Regulation of Transglutaminase 2 Drives Microvascular Leakage in Diabetic Retinas [PDF]

Antioxidants
Microvascular leakage is an early hallmark of diabetic retinopathy (DR), but the redox-dependent mechanisms underlying this dysfunction remain unclear. Here, we investigated whether p38α mitogen-activated protein kinase (MAPK) activates transglutaminase ...
Tae-Yong Koh, Ah-Jun Lee, Chan-Hee Moon, Woo Ri Cho, Ji-Seok Yoon, Minsoo Kim, Kwon-Soo Ha   +6 more
doaj   +2 more sources

Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment [PDF]

Frontiers in Immunology
IntroductionOvarian cancer is the most lethal gynecological malignancy. Deepening our knowledge of the interactions within the tumor microenvironment (TME) is important for discovering new targeted treatment strategies.
Dalia Ibrahim, Dalia Ibrahim, Melanie Grondin, Melanie Grondin, Kristianne Galpin, Kristianne Galpin, Sara Asif, Sara Asif, Emily Thompson, Emily Thompson, Sarah Nersesian, Sarah Nersesian, John Abou-Hamad, John Abou-Hamad, Maryam Echaibi, Maryam Echaibi, Galaxia M. Rodriguez, Galaxia M. Rodriguez, Pauline Navals, Elizabeth Macdonald, Elizabeth Macdonald, Brianna Ryan, David P. Cook, David P. Cook, Jeffrey W. Keillor, Barbara C. Vanderhyden, Barbara C. Vanderhyden   +26 more
doaj   +2 more sources

Transglutaminase 2 regulates endothelial cell calcification via IL-6-mediated autophagy [PDF]

Frontiers in Pharmacology
IntroductionEndothelial cell (EC) calcification is an important marker of atherosclerotic calcification. ECs play a critical role not only in atherogenesis but also in intimal calcification, as they have been postulated to serve as a source of ...
Bo Liu, Zhiyuan Cai, Yan Wang, Xinye Liu, Bin Zhang, Qian Zheng, Jingye Li, Cien Li, Yuanbo Cui, Pengju Lv, Dongwei Yang   +10 more
doaj   +2 more sources

Transglutaminase 2 and Ferroptosis: a new liaison? [PDF]

Cell Death Discovery, 2023
Mara Gagliardi, Valentina Saverio, Federica Rossin, Manuela D’Eletto, Marco Corazzari   +4 more
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Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease

Frontiers in Immunology, 2021
Several environmental, genetic, and immune factors create a “perfect storm” for the development of coeliac disease: the antigen gluten, the strong association of coeliac disease with HLA, the deamidation of gluten peptides by the enzyme transglutaminase ...
Jordan Voisine, Jordan Voisine, Valérie Abadie, Valérie Abadie   +3 more
doaj   +1 more source

Inhibition of the lncRNA Coded within Transglutaminase 2 Gene Impacts Several Relevant Networks in MCF-7 Breast Cancer Cells

Non-Coding RNA, 2021
Long non-coding RNAs are nucleotide molecules that regulate transcription in numerous cellular processes and are related to the occurrence of many diseases, including cancer.
Carlo M. Bergamini, Chiara Vischioni, Gianluca Aguiari, Carmen Grandi, Anna Terrazzan, Stefano Volinia, Nicoletta Bianchi, Cristian Taccioli   +7 more
doaj   +1 more source