Results 11 to 20 of about 23,528 (188)
Applied Sciences, 2021 Background: Tissue type 2 transglutaminase (TG2, E.C. 2.3.2,13) is reported to be involved in the phagocytosis of apoptotic cells in mouse microglial BV2 cells and peripheral macrophages.
Nicola Gaetano Gatta +4 more
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Haematologica, 2019 Differentiation syndrome (DS) is a life-threatening complication arising during retinoid treatment of acute promyelocytic leukemia (APL). Administration of all-trans retinoic acid leads to significant changes in gene expression, among the most induced of
Károly Jambrovics +5 more
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Transglutaminase 2 protects against ischemic stroke
Neurobiology of Disease, 2010 Transglutaminase 2 (TG2) is a multifunctional protein that modulates cell survival and death pathways. It is upregulated in numerous ischemic models, and protects primary neurons from oxygen and glucose deprivation.
A.J. Filiano +4 more
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Inhibiting Transglutaminase 2 Mediates Kidney Fibrosis via Anti-Apoptosis
Biomedicines, 2022 Transglutaminase 2 (TG2) is a calcium-dependent transamidating acyltransferase enzyme of the protein-glutamine γ-glutamyltransferase family implicated in kidney injury. In this study, we identified associations between TG2 and chronic kidney disease (CKD)
Jong-Joo Moon +8 more
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Transglutaminase 2 in human diseases
BioMedicine, 2017 Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co ...
Szondy Zsuzsa +4 more
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Cells, 2020 More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog (MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type p53,
Joon Hee Kang +6 more
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Glucose homeostasis in mice is transglutaminase 2 independent. [PDF]
PLoS ONE, 2013 Transglutaminase type 2 (TG2) has been reported to be a candidate gene for maturity onset diabetes of the young (MODY) because three different mutations that impair TG2 transamidase activity have been found in 3 families with MODY.
Siiri E Iismaa +13 more
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Glycomimetic Peptides as Therapeutic Tools
Pharmaceutics, 2023 The entry of peptides into glycobiology has led to the development of a unique class of therapeutic tools. Although numerous and well-known peptides are active as endocrine regulatory factors that bind to specific receptors, and peptides have been used ...
J. Kenneth Hoober, Laura L. Eggink
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Medical Sciences, 2018 Recent evidence indicated that transglutaminase 2 (TG2) is involved in the adaptive immune response. Peripheral blood mononuclear cells (PBMC) have largely been used to characterize molecular mechanisms occurring in the activation of immune response ...
Daniela Caccamo +4 more
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Calcium‐dependent activation of transglutaminase 2 by nanosecond pulsed electric fields
FEBS Open Bio, 2017 Exposure of cultured human cells to nanosecond pulsed electric fields (nsPEFs) elicits various cellular events, including Ca2+ influx and cell death. Recently, nsPEFs have been regarded as a novel physical treatment useful for biology and medicine, but ...
Keiko Morotomi‐Yano, Ken‐ichi Yano
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