Results 11 to 20 of about 24,604,955 (198)

Biological Functionalities of Transglutaminase 2 and the Possibility of Its Compensation by Other Members of the Transglutaminase Family [PDF]

The Scientific World Journal, 2014
Transglutaminase 2 (TG2) is the most widely distributed and most abundantly expressed member of the transglutaminase family of enzymes, a group of intracellular and extracellular proteins that catalyze the Ca2+-dependent posttranslational modification of
Benedict Onyekachi Odii, Peter Coussons
doaj   +9 more sources

Inhibition of the lncRNA Coded within Transglutaminase 2 Gene Impacts Several Relevant Networks in MCF-7 Breast Cancer Cells

Non-Coding RNA, 2021
Long non-coding RNAs are nucleotide molecules that regulate transcription in numerous cellular processes and are related to the occurrence of many diseases, including cancer.
Carlo M. Bergamini, Chiara Vischioni, Gianluca Aguiari, Carmen Grandi, Anna Terrazzan, Stefano Volinia, Nicoletta Bianchi, Cristian Taccioli   +7 more
doaj   +1 more source

Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]

, 2014
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Schroeder, N, Johnson, TS, Verderio, EAM, Funck, M, Scarpellini, A, Burhan, I, Huang, L   +6 more
core   +1 more source

Transglutaminase 2 protects against ischemic stroke

Neurobiology of Disease, 2010
Transglutaminase 2 (TG2) is a multifunctional protein that modulates cell survival and death pathways. It is upregulated in numerous ischemic models, and protects primary neurons from oxygen and glucose deprivation.
A.J. Filiano, J. Tucholski, P.J. Dolan, G. Colak, G.V.W. Johnson   +4 more
doaj   +1 more source

Neuronutraceuticals Modulate Lipopolysaccharide- or Amyloid-β 1-42 Peptide-Induced Transglutaminase 2 Overexpression as a Marker of Neuroinflammation in Mouse Microglial Cells

Applied Sciences, 2021
Background: Tissue type 2 transglutaminase (TG2, E.C. 2.3.2,13) is reported to be involved in the phagocytosis of apoptotic cells in mouse microglial BV2 cells and peripheral macrophages.
Nicola Gaetano Gatta, Andrea Parente, Francesca Guida, Sabatino Maione, Vittorio Gentile   +4 more
doaj   +1 more source

Glucose homeostasis in mice is transglutaminase 2 independent. [PDF]

PLoS ONE, 2013
Transglutaminase type 2 (TG2) has been reported to be a candidate gene for maturity onset diabetes of the young (MODY) because three different mutations that impair TG2 transamidase activity have been found in 3 families with MODY.
Siiri E Iismaa, Mark Aplin, Sara Holman, Ting W Yiu, Kristy Jackson, James G Burchfield, Christopher J Mitchell, Liam O'Reilly, Aimee Davenport, James Cantley, Carsten Schmitz-Peiffer, Trevor J Biden, Gregory J Cooney, Robert M Graham   +13 more
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Transglutaminase 2 in human diseases

BioMedicine, 2017
Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co ...
Szondy Zsuzsa, Korponay-Szabó Ilma, Király Robert, Sarang Zsolt, Tsay Gregory J.   +4 more
doaj   +1 more source

Evaluation of Process Conditions for Ultrasonic Spray Freeze Drying of Transglutaminase

Food Technology and Biotechnology, 2020
In this study, a commercial transglutaminase enzyme was dried using an ultrasonic spray freeze drying method and the effects of the process conditions were optimized to maximize the final transglutaminase activity.
Hilal Isleroglu, Izzet Turker
doaj   +1 more source

Glycomimetic Peptides as Therapeutic Tools

Pharmaceutics, 2023
The entry of peptides into glycobiology has led to the development of a unique class of therapeutic tools. Although numerous and well-known peptides are active as endocrine regulatory factors that bind to specific receptors, and peptides have been used ...
J. Kenneth Hoober, Laura L. Eggink
doaj   +1 more source

Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits [PDF]

, 2008
Background: In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they
Markku Maki, Korponay-Szabó, Ilma Rita, Korponay-Szabo Ilma R, Lohi, Olli, Ilma R Korponay-Szabo, Katri Haimila, Stenman, Satumarja M., Olli Lohi, Partanen, Jukka, Herbert Wieser, Maki, Markku, Mäki Markku, Lindfors, Katri, Haimila Katri, Paivi Saavalainen, Saavalainen Päivi, Saavalainen, Paivi, Lohi Olli, Stenman, Satumarja M, Partanen Jukka, Kaukinen, Katri, Satumarja M Stenman, Haimila, Katri, Stenman Satumarja M, Wieser Herbert, Katri Kaukinen, Wieser, Herbert, Kaukinen Katri, Korponay-Szabó, Ilma, Katri Lindfors, Jukka Partanen, Lindfors Katri   +31 more
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