Results 41 to 50 of about 24,604,955 (198)

A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells

Frontiers in Endocrinology, 2023
IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long non-coding RNAs (lncRNA), but the ...
Itziar González-Moro, Itziar González-Moro, Henar Rojas-Márquez, Henar Rojas-Márquez, Maialen Sebastian-delaCruz, Maialen Sebastian-delaCruz, Jon Mentxaka-Salgado, Jon Mentxaka-Salgado, Ane Olazagoitia-Garmendia, Ane Olazagoitia-Garmendia, Ane Olazagoitia-Garmendia, Luis Manuel Mendoza, Luis Manuel Mendoza, Aina Lluch, Aina Lluch, Federica Fantuzzi, Carmen Lambert, Carmen Lambert, Jessica Ares Blanco, Jessica Ares Blanco, Jessica Ares Blanco, Lorella Marselli, Piero Marchetti, Miriam Cnop, Miriam Cnop, Elías Delgado, Elías Delgado, Elías Delgado, Elías Delgado, José Manuel Fernández-Real, José Manuel Fernández-Real, José Manuel Fernández-Real, Francisco José Ortega, Francisco José Ortega, Ainara Castellanos-Rubio, Ainara Castellanos-Rubio, Ainara Castellanos-Rubio, Ainara Castellanos-Rubio, Izortze Santin, Izortze Santin, Izortze Santin   +40 more
doaj   +1 more source

Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces

Advanced Functional Materials, EarlyView.
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng, TzuChun Chung, Katpady Akhil Tantry, Siyu Wu, Jing Tian, Yunqi Cui, Lanyu Li, Yongzan Zhou, Zhilei Zhang, Zhe Su, Gaili Cao, Kun‐Wei Yeh, Ruipeng Li, Xianghui Xiao, Adam F. G. Leontowich, Yuan‐Yu Hsueh, Zhao Pan, Kam C. Tam, Badri Narayanan, Song Li, Yimin. A. Wu   +20 more
wiley   +1 more source

Effects of organophosphates on neural and purified liver tissue transglutaminase [PDF]

, 2010
Transglutaminase 2 (TGase 2) is a multifunctional calcium dependent enzyme that catalyzes protein modifications. TGase 2 is essential in neuronal cell differentiation and it has been reported that certain organophosphates are able to inhibit this process,
Muñoz, D
core  

Biological Implications and Functional Significance of Transglutaminase Type 2 in Nervous System Tumors

Cells
Transglutaminase type 2 (TG2) is the most ubiquitously expressed member of the transglutaminase family. TG2 catalyzes the transamidation reaction leading to several protein post-translational modifications and it is also implicated in signal transduction
Mariachiara Buccarelli, Giorgia Castellani, Vincenzo Fiorentino, Cristina Pizzimenti, Simone Beninati, Lucia Ricci-Vitiani, Maria Luisa Scattoni, Carlo Mischiati, Francesco Facchiano, Claudio Tabolacci   +9 more
doaj   +1 more source

Biodegradable and Edible Milli‐Fluidic Logic Circuits

Advanced Materials Technologies, EarlyView.
Fully biodegradable and edible fluidic circuits are developed using gelatin‐based valves that operate at low pressure. Logic gates, a one‐bit memory, and a ring oscillator are demonstrated, showing that biodegradable materials can perform computation and control.
Shuhang Zhang, Bokeon Kwak, Özgün Ekrem, Dario Floreano   +3 more
wiley   +1 more source

Polimerização de proteínas do soro de leite por transglutaminase e propriedades físicas de iogurte elaborado após tratamento enzimático [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência dos Alimentos.The aim of this study was to assess the optimal conditions for transglutaminase cross-linking of whey ...
Gauche, Cony
core  

Conformational Modulation of Tissue Transglutaminase via Active Site Thiol Alkylating Agents: Size Does Not Matter

Biomolecules
TG2 is a unique member of the transglutaminase family as it undergoes a dramatic conformational change, allowing its mutually exclusive function as either a cross-linking enzyme or a G-protein.
Pauline Navals, Alana M. M. Rangaswamy, Petr Kasyanchyk, Maxim V. Berezovski, Jeffrey W. Keillor   +4 more
doaj   +1 more source

The Role and Mechanism of Transglutaminase 2 in Regulating Hippocampal Neurogenesis after Traumatic Brain Injury

Cells, 2023
Traumatic brain injury usually results in neuronal loss and cognitive deficits. Promoting endogenous neurogenesis has been considered as a viable treatment option to improve functional recovery after TBI.
Ruo-Xi Shi, Cong Liu, Ya-Jie Xu, Ying-Ying Wang, Bao-Dong He, Xuan-Cheng He, Hong-Zhen Du, Baoyang Hu, Jianwei Jiao, Chang-Mei Liu, Zhao-Qian Teng   +10 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Propriedades físicas e químicas de queijos cremosos: influência de polissacarídeos e transglutaminase [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência dos Alimentos.Os objetivos deste trabalho foram: avaliar a influência de polissacarídeos, nas propriedades físicas e ...
Sá, Estela Mary Fernandes de
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