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Coeliac disease [PDF]

Nature Reviews Disease Primers, 2019
Coeliac disease is an immune-mediated enteropathy against dietary gluten present in wheat, rye and barley and is one of the most common lifelong food-related disorders worldwide. Coeliac disease is also considered to be a systemic disorder characterized by a variable combination of gluten-related signs and symptoms and disease-specific antibodies in ...
Katri Lindfors, Carolina Ciacci, Kalle Kurppa   +2 more
exaly   +10 more sources

Coeliac disease

Best Practice & Research Clinical Gastroenterology, 2002
Increased awareness of non-classical presentations and more reliable screening tests have led to higher detection rates for coeliac disease in elderly adults. Clinical presentations are influenced largely by the long-standing course of the subclinical disease before diagnosis.
Hugh, Freeman, Michel, Lemoyne, Pierre, Pare   +2 more
core   +7 more sources

Coeliac disease in The Netherlands

Scandinavian Journal of Gastroenterology, 2004
The prevalence of adult coeliac disease in The Netherlands was studied in the Dutch Coeliac Disease Society and in blood donors but not in the general population. We therefore studied the prevalence of recognized and unrecognized coeliac disease in a large cohort, representative of the adult Dutch general population.
Schweizer, JJ, von Blomberg, BME, Bueno de Mesquita, HBrivm, Mearin, ML   +3 more
openaire   +6 more sources

Coeliac Disease [PDF]

Autoimmune Diseases, 2014
Coeliac disease is an autoimmune enteropathy triggered by the ingestion of gluten-containing cereals, such as wheat, rye and barley. It is estimated to occur in one per cent of people of European ancestry, and in 0.3% of black Africans.
NENNA, RAFFAELLA, Stefano Guandalini, Alina Popp, Kalle Kurppa   +3 more
core   +7 more sources

Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning

Frontiers in Immunology, 2021
Chronic inflammation of the small intestine in celiac disease is driven by activation of CD4+ T cells that recognize gluten peptides presented by disease-associated HLA-DQ molecules.
Shuo-Wang Qiao, Shuo-Wang Qiao, Shiva Dahal-Koirala, Shiva Dahal-Koirala, Linn M. Eggesbø, Knut E. A. Lundin, Knut E. A. Lundin, Ludvig M. Sollid, Ludvig M. Sollid   +8 more
doaj   +1 more source

Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T‐Cell‐Directed Therapies

Advanced Science, 2021
Gluten‐specific CD4+ T cells being drivers of celiac disease (CeD) are obvious targets for immunotherapy. Little is known about how cell markers harnessed for T‐cell‐directed therapy can change with time and upon activation in CeD and other autoimmune ...
Asbjørn Christophersen, Stephanie Zühlke, Eivind G. Lund, Omri Snir, Shiva Dahal‐Koirala, Louise Fremgaard Risnes, Jørgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid   +8 more
doaj   +1 more source

Phenotype‐Based Isolation of Antigen‐Specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease

Advanced Science, 2022
The pathogenic immune response in celiac disease (CeD) is orchestrated by phenotypically distinct CD4+ T cells that recognize gluten epitopes in the context of disease‐associated HLA‐DQ allotypes.
Asbjørn Christophersen, Shiva Dahal‐Koirala, Markéta Chlubnová, Jørgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid   +5 more
doaj   +1 more source

Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs

Frontiers in Immunology, 2021
Gluten-specific CD4+ T cells are drivers of celiac disease (CeD). Previous studies of gluten-specific T-cell receptor (TCR) repertoires have found public TCRs shared across multiple individuals, biased usage of particular V-genes and conserved CDR3 ...
Shiva Dahal-Koirala, Shiva Dahal-Koirala, Louise Fremgaard Risnes, Louise Fremgaard Risnes, Ralf Stefan Neumann, Asbjørn Christophersen, Asbjørn Christophersen, Knut E. A. Lundin, Knut E. A. Lundin, Knut E. A. Lundin, Geir Kjetil Sandve, Shuo-Wang Qiao, Shuo-Wang Qiao, Ludvig M. Sollid, Ludvig M. Sollid   +14 more
doaj   +1 more source

Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3

Nature Communications, 2023
Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a calcium dependent enzyme that targets glutamine residues in polypeptides for either transamidation or deamidation modifications.
Julie Elisabeth Heggelund, Saykat Das, Jorunn Stamnaes, Rasmus Iversen, Ludvig M. Sollid   +4 more
doaj   +1 more source

Association between coeliac disease and cardiovascular disease: prospective analysis of UK Biobank data

BMJ Medicine, 2023
Objectives To investigate whether people with coeliac disease are at increased risk of cardiovascular disease, including ischaemic heart disease, myocardial infarction, and stroke.Design Prospective analysis of a large cohort study.Setting UK Biobank ...
Elizabeth Soilleux, Megan Conroy, Naomi Allen, Thomas Littlejohns, Ben Lacey   +4 more
doaj   +1 more source