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Coeliac disease [PDF]

South African Family Practice, 2014
Coeliac disease is an autoimmune enteropathy triggered by the ingestion of gluten-containing cereals, such as wheat, rye and barley. It is estimated to occur in one per cent of people of European ancestry, and in 0.3% of black Africans.
J. Badenhorst
doaj   +9 more sources

Coeliac disease [PDF]

Best Practice & Research Clinical Gastroenterology, 2002
Increased awareness of non-classical presentations and more reliable screening tests have led to higher detection rates for coeliac disease in elderly adults. Clinical presentations are influenced largely by the long-standing course of the subclinical disease before diagnosis.
Hugh, Freeman, Michel, Lemoyne, Pierre, Pare   +2 more
core   +7 more sources

Coeliac disease [PDF]

The Lancet, 2022
Coeliac disease is an autoimmune disorder that primarily affects the small intestine, and is caused by the ingestion of gluten in genetically susceptible individuals. Prevalence in the general population ranges from 0·5% to 2%, with an average of about 1%.
Carlo, Catassi, Elena F, Verdu, Julio Cesar, Bai, Elena, Lionetti   +3 more
openaire   +3 more sources

Coeliac disease in The Netherlands [PDF]

Scandinavian Journal of Gastroenterology, 2004
The prevalence of adult coeliac disease in The Netherlands was studied in the Dutch Coeliac Disease Society and in blood donors but not in the general population. We therefore studied the prevalence of recognized and unrecognized coeliac disease in a large cohort, representative of the adult Dutch general population.
Schweizer, JJ, von Blomberg, BME, Bueno de Mesquita, HBrivm, Mearin, ML   +3 more
openaire   +6 more sources

Developing a Measure to Assess General Knowledge for Coeliac Disease [PDF]

Health Expectations
Background The importance of establishing knowledge about coeliac disease relates to the increasing incidence of symptomatic individuals who are undiagnosed.
Tiffany Lavis, K. Ann Horsburgh, Jacqueline F. Gould, Elizabeth Bingham Thomas   +3 more
doaj   +2 more sources

Prevalence of oral manifestations in coeliac disease and associated factors [PDF]

BMC Gastroenterology
Background Various oral manifestations are associated with coeliac disease in children, whereas data on adults are scarce. Moreover, possible individual factors predisposing to these manifestations remain unresolved.
Jani Manninen, Saana Paavola, Kalle Kurppa, Heini Huhtala, Teea Salmi, Katri Kaukinen, Camilla Pasternack   +6 more
doaj   +2 more sources

Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning

Frontiers in Immunology, 2021
Chronic inflammation of the small intestine in celiac disease is driven by activation of CD4+ T cells that recognize gluten peptides presented by disease-associated HLA-DQ molecules.
Shuo-Wang Qiao, Shuo-Wang Qiao, Shiva Dahal-Koirala, Shiva Dahal-Koirala, Linn M. Eggesbø, Knut E. A. Lundin, Knut E. A. Lundin, Ludvig M. Sollid, Ludvig M. Sollid   +8 more
doaj   +1 more source

Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T‐Cell‐Directed Therapies

Advanced Science, 2021
Gluten‐specific CD4+ T cells being drivers of celiac disease (CeD) are obvious targets for immunotherapy. Little is known about how cell markers harnessed for T‐cell‐directed therapy can change with time and upon activation in CeD and other autoimmune ...
Asbjørn Christophersen, Stephanie Zühlke, Eivind G. Lund, Omri Snir, Shiva Dahal‐Koirala, Louise Fremgaard Risnes, Jørgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid   +8 more
doaj   +1 more source

Phenotype‐Based Isolation of Antigen‐Specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease

Advanced Science, 2022
The pathogenic immune response in celiac disease (CeD) is orchestrated by phenotypically distinct CD4+ T cells that recognize gluten epitopes in the context of disease‐associated HLA‐DQ allotypes.
Asbjørn Christophersen, Shiva Dahal‐Koirala, Markéta Chlubnová, Jørgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid   +5 more
doaj   +1 more source

Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs

Frontiers in Immunology, 2021
Gluten-specific CD4+ T cells are drivers of celiac disease (CeD). Previous studies of gluten-specific T-cell receptor (TCR) repertoires have found public TCRs shared across multiple individuals, biased usage of particular V-genes and conserved CDR3 ...
Shiva Dahal-Koirala, Shiva Dahal-Koirala, Louise Fremgaard Risnes, Louise Fremgaard Risnes, Ralf Stefan Neumann, Asbjørn Christophersen, Asbjørn Christophersen, Knut E. A. Lundin, Knut E. A. Lundin, Knut E. A. Lundin, Geir Kjetil Sandve, Shuo-Wang Qiao, Shuo-Wang Qiao, Ludvig M. Sollid, Ludvig M. Sollid   +14 more
doaj   +1 more source